Double-acceptor conjugated polymers for NIR-II fluorescence imaging and NIR-II photothermal therapy applications

Chen, Yan; Sun, Bo; Jiang, Xinyue; Yuan, Zhangyu; Chen, Shangyu; Sun, Pengfei; Fan, Quli; Huang, Wei

doi:10.1039/d0tb02499f

Cited by 79 publications

(74 citation statements)

References 46 publications

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“…Semiconductor polymer dots (Pdots) are a new type of organic fluorescent material that has emerged in recent years. Compared with conventional fluorescent dyes, Pdots have broad absorption, symmetric narrow emission, high luminance, high photostability and large Stokes shift ( Chen et al, 2021 ). Therefore, nanoparticles composed of highly fluorescent semiconductor polymers are considered as an effective fluorescent probe and show promising applications in bioimaging, molecular detection, and guiding drug therapy.…”

Section: Categories Of Nir-ii Fluorescent Probesmentioning

confidence: 99%

“…Recent studies have shown that biological imaging in the second near-infrared region (NIR-II, 1,000–1700 nm) can achieve higher penetration depth (up to 20 mm) and spatial-temporal resolution, so as to obtain a better image quality ( Wang et al, 2014 ; Li and Pu, 2018 ). With the development of chemical synthesis, there have been several fluorescent probes employed for NIR-II biomedical imaging, including single-walled carbon nanotubes (SWCNTs), small organic molecules, rare-earth-doped nanoparticles (RENPs), quantum dots (QDs), conjugated polymers and other inorganic nanoparticles ( Antaris et al, 2016 ; Cai et al, 2019 ; Chen et al, 2020 ; Du et al, 2020 ; Mandal et al, 2020 ; Yu et al, 2020 ; Chen et al, 2021 ). In this paper, the recent developed fluorescent probes for NIR-II imaging and their biomedical applications are reviewed (shown in Figure 1 ) and prospected, in order to promote clinical translation and inspire new ideas for the development of NIR-II fluorescent imaging technology.…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances in Second Near-Infrared Region (NIR-II) Fluorophores and Biomedical Applications

et al. 2021

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Fluorescence imaging technique, characterized by high sensitivity, non-invasiveness and no radiation hazard, has been widely applicated in the biomedical field. However, the depth of tissue penetration is limited in the traditional (400–700 nm) and NIR-I (the first near-infrared region, 700–900 nm) imaging, which urges researchers to explore novel bioimaging modalities with high imaging performance. Prominent progress in the second near-infrared region (NIR-II, 1000–1700 nm) has greatly promoted the development of biomedical imaging. The NIR-II fluorescence imaging significantly overcomes the strong tissue absorption, auto-fluorescence as well as photon scattering, and has deep tissue penetration, micron-level spatial resolution, and high signal-to-background ratio. NIR-II bioimaging has been regarded as the most promising in vivo fluorescence imaging technology. High brightness and biocompatible fluorescent probes are crucial important for NIR-II in vivo imaging. Herein, we focus on the recently developed NIR-II fluorescent cores and their applications in the field of biomedicine, especially in tumor delineation and image-guided surgery, vascular imaging, NIR-II-based photothermal therapy and photodynamic therapy, drug delivery. Besides, the challenges and potential future developments of NIR-II fluorescence imaging are further discussed. It is expected that our review will lay a foundation for clinical translation of NIR-II biological imaging, and inspire new ideas and more researches in this field.

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Section: Categories Of Nir-ii Fluorescent Probesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Advances in Second Near-Infrared Region (NIR-II) Fluorophores and Biomedical Applications

et al. 2021

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“…However, the applications of this technique is further limited due to its relatively shallow tissue penetration depth in the traditional NIR-I region ( Lyu et al, 2019 ). Currently, the biologically-related applications of NIR-II has aroused great interest, which can be used for NIR-II PTT and NIR-II fluorescence imaging ( Liu et al, 2019 ; Suo et al, 2019 ; Chen et al, 2021 ). It has the advantages of low light scattering, high spatial resolution and deep tissue penetration ( Yang et al, 2017a ).…”

Section: Introductionmentioning

confidence: 99%

Recent Progress on NIR-II Photothermal Therapy

Zhang

et al. 2021

Front. Chem.

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Photothermal therapy is a very promising treatment method in the field of cancer therapy. The photothermal nanomaterials in near-infrared region (NIR-I, 750-900 nm) attracts extensive attention in recent years because of the good biological penetration of NIR light. However, the penetration depth is still not enough for solid tumors due to high tissue scattering. The light in the second near-infrared region (NIR-II, 1000-1700 nm) allows deeper tissue penetration, higher upper limit of radiation and greater tissue tolerance than that in the NIR-I, and it shows greater application potential in photothermal conversion. This review summarizes the photothermal properties of Au nanomaterials, two-dimensional materials, metal oxide sulfides and polymers in the NIR-II and their application prospects in photothermal therapy. It will arouse the interest of scientists in the field of cancer treatment as well as nanomedicine.

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“…Semiconducting polymer nanoparticles (SPNs) composed of completely organic compounds have been emerged as photothermal agents for tumor therapy [ 26 – 29 ]. Compared with other inorganic nanomaterials such as gold nanorods and carbon nanotubes, SPNs possess unique characteristics such as better biocompatibility, higher NIR absorption and photothermal conversion efficiency, feasibility and controllability [ 30 – 34 ].…”

Section: Introductionmentioning

confidence: 99%

Semiconducting polymer nano-radiopharmaceutical for combined radio-photothermal therapy of pancreatic tumor

Shi

Zhang

et al. 2021

J Nanobiotechnol

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Background Pancreatic ductal adenocarcinoma (PDAC) is a devastatingly malignant tumor with a high mortality. However, current strategies to treat PDAC generally have low efficacy and high side-effects, therefore, effective treatment against PDAC remains an urgent need. Results We report a semiconducting polymer nano-radiopharmaceutical with intrinsic photothermal capability and labeling with therapeutic radioisotope 177Lu (177Lu-SPN-GIP) for combined radio- and photothermal therapy of pancreatic tumor. 177Lu-SPN-GIP endowed good stability at physiological conditions, high cell uptake, and long retention time in tumor site. By virtue of combined radiotherapy (RT) and photothermal therapy (PTT), 177Lu-SPN-GIP exhibited enhanced therapeutic capability to kill cancer cells and xenograft tumor in living mice compared with RT or PTT alone. More importantly, 177Lu-SPN-GIP could suppress the growth of the tumor stem cells and reverse epithelial mesenchymal transition (EMT), which may greatly reduce the occurrence of metastasis. Conclusion Such strategy we developed could improve therapeutic outcomes over traditional RT as it is able to ablate tumor with relatively lower doses of radiopharmaceuticals to reduce its side effects. Graphical abstract

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Double-acceptor conjugated polymers for NIR-II fluorescence imaging and NIR-II photothermal therapy applications

Abstract: Nanoparticles based double-acceptor conjugated polymers were developed by conventional methods. And subsequently NPs with bright NIR-II fluorescence signals and superior NIR-II PTT efficiency were successfully applied for NIR-II FI guided NIR-II PTT.

Cited by 79 publications

References 46 publications

Recent Advances in Second Near-Infrared Region (NIR-II) Fluorophores and Biomedical Applications

Recent Advances in Second Near-Infrared Region (NIR-II) Fluorophores and Biomedical Applications

Recent Progress on NIR-II Photothermal Therapy

Semiconducting polymer nano-radiopharmaceutical for combined radio-photothermal therapy of pancreatic tumor

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