Double blind comparison of combination of 0.1% ropivacaine and fentanyl to combination of 0.1% bupivacaine and fentanyl for extradural analgesia in labour

Bawdane, Kishori Dhaku; Magar, Jyoti; Tendolkar, Bharati A

doi:10.4103/0970-9185.173350

Cited by 18 publications

(10 citation statements)

References 21 publications

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“…Bawdane et al ( 20 ) recorded similar pain scores, sensory levels, and overall maternal satisfaction between the two groups, as we observed. Although ropivacaine is suggested to be less potent than bupivacaine ( 21 ) , they appear to be equipotent at clinically used concentrations.…”

Section: Discussionsupporting

confidence: 88%

Comparison of bupivacaine and ropivacaine in combination with fentanyl used for walking epidural anesthesia in labor

Gündüz

Yalçın

Karakoç

et al. 2017

tjod

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Objective:Effective pain relief during labor is essential to reduce maternal and perinatal morbidity arising due to pain-induced maternal sympathetic activation, and to avoid unnecessary cesarean sections performed due to maternal anxiety. Walking epidural analgesia on labor reveals lower pain scores, leading to higher maternal satisfaction with better cardiovascular and pulmonary physiology. Despite the extensive use and relative safety of bupivacaine, newer drugs such as ropivacaine have been developed as alternative agents to decrease the risk for cardiac and central nervous system toxicity.Materials and Methods:One hundred women who requested epidural analgesia in active labor were randomly allocated into two groups; one group received 20 mL of ropivacaine 0.125% with fentanyl 50 µg and the other received 20 mL of bupivacaine 0.125% with fentanyl 50 µg. The efficacy of analgesia, adverse effects, and obstetric and neonatal outcomes of both groups were compared.Results:There were no differences between the two study groups in the measured obstetric and neonatal outcomes. The onset time, duration of analgesia, and sensory levels were similar between the groups. Visual analog pain scale scores did not differ between the groups before analgesia or at any of the subsequent evaluation periods.Conclusion:Both ropivacaine and bupivacaine provide equivalent labor analgesia with high maternal satisfaction and tolerable adverse effects in the clinically used dose range. No adverse obstetric or neonatal outcomes were observed in either group. Therefore, either drug is a reasonable choice for labor analgesia and can be used without jeopardizing the safety of the mother and fetus.

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Section: Discussionsupporting

confidence: 88%

Comparison of bupivacaine and ropivacaine in combination with fentanyl used for walking epidural anesthesia in labor

Gündüz

Yalçın

Karakoç

et al. 2017

tjod

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“…Traction response score dexmedetomidine combined with lumbar anesthesia enhances the anesthetic effect and promotes recovery of maternal patients after caesarean section. Post-operative anesthesia-associated complications are one of the problems that affect the surgical process and post-operative recovery of caesarean section patients, mainly including pruritus, post-operative pain, respiratory depression, chills and hypotension (24,25). However, in the present study, the use of dexmedetomidine combined with lumbar anesthesia was indicated to reduce adverse reactions and traction response.…”

Section: Discussionmentioning

confidence: 75%

Effect of dexmedetomidine combined with lumbar anesthesia on Th1/Th2 in maternal patients and neonates undergoing caesarean section

Shi

Zhang

2019

Exp Ther Med

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The selection of anesthetic method and drugs is of utmost importance for patients undergoing caesarean section. The application of anesthetic drugs may affect the immune system of the maternal patient and neonate. Therefore, the present study aimed to analyze the effect of dexmedetomidine combined with lumbar anesthesia on type 1 T-helper cells (Th1) and Th2 cytokines in mothers and their neonates undergoing caesarean section. A total of 60 females with full-term pregnancies and an American Society of Anesthesiologists grade I or II who received caesarean section were selected and equally divided in a randomized manner into a control group receiving lumbar epidural anesthesia and a combination group treated by dexmedetomidine combined with lumbar epidural anesthesia. The visual analogue scale (VAS) score, adverse reactions, traction response and the neonates' Apgar score were compared between the two groups. The levels of interleukin-2 (IL-2), tumor necrosis factor-α (TNF-α), IL-4 and IL-10 in the blood of mothers and neonates were detected by reverse transcription-quantitative PCR and ELISA. The results indicated no statistically significant difference in the Apgar score between the two groups. The VAS scores, adverse reactions, reduced traction response, as well as IL-2 and TNF-α expression, in the mothers of the combination group were significantly decreased, while IL-4 and IL-10 were obviously elevated compared with those in the controls (P<0.05). Furthermore, IL-2 and TNF-α levels were markedly declined, whereas IL-4 and IL-10 expression was apparently enhanced in the neonates from the combination group compared with those in the control group (P<0.05). In conclusion, dexmedetomidine in addition to lumbar epidural anesthesia reduces the VAS score, adverse reactions and traction response, and promotes the conversion of Th1 cytokines to Th2 cytokines in mothers/nonates after caesarean section.

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“…In studies that evaluated intrathecal administration of 15-25 mg isobaric ropivacaine, the motor block time was shown to be related to the dose administered. [5][6][7][8] In another study, incremental doses of ropivacaine were found to be responsible for a longer motor block time. 9 During a cesarean section, muscle relaxation is an important part of surgery, whereas a shorter motor block time facilitates early mobilization.…”

Section: Discussionmentioning

confidence: 94%

“…The clinical studies did not report neurological side effects associated with the intrathecal administration of ropivacaine. 6,14…”

Section: Discussionmentioning

confidence: 99%

Comparative study of clinical efficacy and safety of intrathecal isobaric ropivacaine 0.75% with fentanyl versus isobaric ropivacaine 0.75% alone for caesarean

Gandhi¹,

Agrawal²,

Agrawal³

et al. 2020

Int J Sci Rep

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Background: Compare the clinical efficacy and safety of intrathecal isobaric ropivacaine 0.75% with fentanyl, 10 mcg vs isobaric ropivacaine 0.75% alone for caesarean section.Methods: Two hundred patients were considered eligible for the study of which one hundred and sixty-eight patients undergoing caesarean section under spinal anesthesia and were included in the study. Parturient to ASA physical status I-II scheduled for caesarean section were randomly selected for the study and are divided into group of 84 each.Results: There was significant difference in sensory block duration at T10 (min) and total duration of analgesia (min) in both groups. This difference between two group’s was not significant. Adverse Effects in group RF 5 (5.9%) patients had hypotension and 2 (2.3%) bradycardias in group R 3 (3.5%) patient had hypotension.Conclusions: Hemodynamic parameters were comparable in both the groups. Total duration of analgesia and sensory block duration at T10 was significantly shorter with ropivacaine (with saline) compared to ropivacaine with fentanyl.

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Double blind comparison of combination of 0.1% ropivacaine and fentanyl to combination of 0.1% bupivacaine and fentanyl for extradural analgesia in labour

Cited by 18 publications

References 21 publications

Comparison of bupivacaine and ropivacaine in combination with fentanyl used for walking epidural anesthesia in labor

Comparison of bupivacaine and ropivacaine in combination with fentanyl used for walking epidural anesthesia in labor

Effect of dexmedetomidine combined with lumbar anesthesia on Th1/Th2 in maternal patients and neonates undergoing caesarean section

Comparative study of clinical efficacy and safety of intrathecal isobaric ropivacaine 0.75% with fentanyl versus isobaric ropivacaine 0.75% alone for caesarean

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