Double‐blind comparison of epidural diamorphine and intramuscular morphine after elective Caesarean section, with computerised analysis of continuous pulse oximetry

Stevens, J. D.; Braithwaite, P.; Corke, C. F.; Madej, T.H.; Wheatley, R.G.

doi:10.1111/j.1365-2044.1991.tb11491.x

Cited by 13 publications

(7 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The median dose of i.m. morphine required by patients in the diamorphine group was 0 mg. Stevens et al (5), who gave 3 mg of epidural diamorphine after caesarean section identified a mean morphine dose requirement of 18 mg; compared with our study, this suggests that there are advantages both in giving a larger dose of epidural diamorphine, and in administering epidural opioids at the time of surgery. I n the same study it was shown that the mean cumulative i.m.…”

Section: Methadone Diamorphinesupporting

confidence: 58%

“…Significant numbers of patients in both groups admitted to pruritis on direct questioning, one patient in each group describing it as severe, as also noted by McGrady et al (2). We disagree with Stevens et al (5) who dismissed pruritis as not being a significant side effect of epidural diamorphine.…”

Section: Methadone Diamorphinementioning

confidence: 51%

“…The use of epidural opioids to provide analgesia either during labour or following caesarean section has been widely reported (1)(2)(3)(4)(5). The overall impression is that this technique is both effective and safe, despite concern regarding side effects of nausea, pruritis, urinary Table 2 Patients with clinically significant hypoxaemia (Spo, < 90% for 30 s or longer).…”

Section: Discussionmentioning

confidence: 99%

“…Both Stevens et al (5) and McGrady et al (2) noted the emetic effect of epidural diamorphine. Although the median VAS's in both groups of patients for nausea were low throughout in our study, the range was large, with several patients in both groups experiencing severe nausea and vomiting.…”

Section: Methadone Diamorphinementioning

confidence: 99%

See 3 more Smart Citations

Comparison of epidural methadone with epidural diamorphine for analgesia following caesarean section

Haynes¹,

Allsop²,

Davidson³

et al. 1993

International Journal of Obstetric Anesthesia

View full text Add to dashboard Cite

Section: Methadone Diamorphinesupporting

confidence: 58%

Section: Methadone Diamorphinementioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Methadone Diamorphinementioning

confidence: 99%

See 2 more Smart Citations

Comparison of epidural methadone with epidural diamorphine for analgesia following caesarean section

Haynes¹,

Allsop²,

Davidson³

et al. 1993

International Journal of Obstetric Anesthesia

View full text Add to dashboard Cite

“…However, Withington, Patrick & Reynolds (1993) found that heroin causes histamine release as frequently as morphine in patients undergoing low-dose pain treatment. Urinary dys function seems to be of no clinical importance in tolerant subjects as opposed to nontolerant subjects (Stevens et al 1991;Bromage et al 1982a, b).…”

mentioning

confidence: 95%

Effects of High-Dose Heroin versus Morphine in Intravenous Drug Users: A Randomised Double-Blind Crossover Study

Haemmig¹,

Tschacher²

2001

Journal of Psychoactive Drugs

View full text Add to dashboard Cite

The purpose of this study is to evaluate the effects of high doses of injected opiates as prescribed maintenance in intravenous drugs users. This was accomplished via a randomised double-blind study with crossover at an outpatient clinic in Bern, Switzerland. The subjects were 39 patients with a long history of intravenous opioid use and persistent abuse despite treatment; they were randomly allocated to two groups. Group A was started on controlled injection of graduated doses of morphine up to a satisfying individual dose and was then switched as a double blind to heroin at a randomly determined day between week three and four. Subsequently this group was given heroin for the remaining two to three weeks of the study. Group B was started on heroin and was then switched to morphine in the same manner. Equipotent solutions of 3% morphine and 2% heroin were administered. The main outcome measures were clinical observations, structural interviews and self report of subjective experiences to assess the effects of the drugs. In 16 cases, the study had to be discontinued owing to severe morphine-induced histamine reactions. Thirteen participants in Group B presented these adverse reactions on the day of the switch-over. Full data were thus only obtainable for 17 participants. Average daily doses were 491 mg for heroin and 597 mg for morphine. The findings indicate that heroin significantly produced a lower grade of itching, flushing, urticaria and pain/nausea. A negative correlation between dose and euphoria was observed for both heroin and morphine. The authors concluded that as heroin produces fewer side effects it is the preferred high-dose maintenance prescription to morphine. The perceived euphoric effects are limited in both substances.

show abstract

Effect of general anesthesia and major versus minor surgery on late postoperative episodic and constant hypoxemia

Rosenberg

Oturai

Erichsen

et al. 1994

Journal of Clinical Anesthesia

View full text Add to dashboard Cite

Double‐blind comparison of epidural diamorphine and intramuscular morphine after elective Caesarean section, with computerised analysis of continuous pulse oximetry

Abstract: Summary

Cited by 13 publications

References 20 publications

Comparison of epidural methadone with epidural diamorphine for analgesia following caesarean section

Comparison of epidural methadone with epidural diamorphine for analgesia following caesarean section

Effects of High-Dose Heroin versus Morphine in Intravenous Drug Users: A Randomised Double-Blind Crossover Study

Effect of general anesthesia and major versus minor surgery on late postoperative episodic and constant hypoxemia

Contact Info

Product

Resources

About