Double-blind placebo-controlled comparison of dezocine and morphine for post-operative pain relief

Pandit, Sujit K.; Kothary, Sarla P.; Pandit, Uma A.; Kunz, Nadia R.

doi:10.1007/bf03011403

Cited by 16 publications

(11 citation statements)

References 12 publications

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“…Of the 7 included studies, 3 [ 7 , 18 , 20 ] (n = 234) compared the effectiveness of dezocine versus placebo according to the number of patients with at least 50% pain relief achieved within 0–6 h after surgery. These three studies found that dezocine significantly increased the proportion of patients with at least 50% pain relief within 0–6 h after surgery (15 min: N = 234; RR 2.95, 95% CI 1.30 to 6.70; I² = 70%, 95% CI 0% to 91%; χ 2 = 6.64, P = 0.004; 30 min: N = 234; RR 2.52, 95% CI 1.11 to 5.73; I² = 84%, 95% CI 53% to 95%; χ 2 = 12.81, P = 0.002; 1 h: N = 234; RR 2.74, 95% CI 1.11 to 6.76; I² = 87%, 95% CI 64% to 96%; χ 2 = 15.65, P = 0.0004; 2 h: N = 234; RR 2.89, 95% CI 1.61 to 5.19; I² = 49%, 95% CI 0% to 85%; χ 2 = 3.96, P = 0.14; 3 h: N = 159; RR 4.10, 95% CI 1.91 to 8.80; I² = 0%, 95% CI is not applicable; χ 2 = 0.08, P = 0.77; 4 h: N = 234; RR 4.23, 95% CI 1.94 to 9.22; I² = 0%, 95% CI 0% to 90%; χ 2 = 1.35, P = 0.51; 5 h: N = 159, RR 5.78, 95% CI 1.59 to 21.00; I² = 0%, 95% CI is not applicable; χ 2 = 0.01, P = 0.90; and 6 h: N = 159; RR 3.78, 95% CI 0.99 to 14.51; I² = 0%, 95% CI is not applicable; χ 2 = 0.03, P = 0.86).…”

Section: Resultsmentioning

confidence: 99%

“…Three studies [ 6 , 18 , 20 ] (n = 235) compared the effectiveness of dezocine versus morphine according to the number of patients reporting at least 50% pain relief. These three studies showed that dezocine had an effect similar to morphine, as demonstrated by the similar numbers of patients with at least 50% pain relief reported during the late postoperative period (within 2–6 h) (2 h: N = 235; RR 1.19, 95% CI 0.96 to 1.47; I² = 0%, 95% CI 53% to 95%; χ 2 = 0.77, P = 0.68; 3 h: N = 79, RR 1.09, 95% CI 0.66 to 1.78; 4 h: N = 235, RR 1.08, 95% CI 0.76 to 1.55; I² = 0%, 95% CI 0% to 90%; χ 2 = 0.95, P = 0.62; 5 h: N = 79, RR 1.76, 95% CI 0.77 to 4.00; and 6 h: N = 79, RR 1.37, 95% CI 0.52 to 3.58).…”

Section: Resultsmentioning

confidence: 99%

“…Three studies [ 16 , 18 , 20 ] (n = 234) compared the effectiveness of dezocine versus morphine on physician satisfaction. These three studies showed that dezocine did not have a significant effect on physician satisfaction compared with morphine (N = 234; RR 1.18, 95% CI 0.93 to 1.49; I² = 0%, 95% CI 0% to 90%; χ 2 = 0.22, P = 0.89).…”

Section: Resultsmentioning

confidence: 99%

“…Three studies [ 6 , 16 , 18 ] (n = 235) compared PONV with dezocine or morphine. Analysis showed that dezocine had no significant advantage over morphine in terms of PONV (N = 235; RR 0.65, 95% CI 0.14 to 2.93; I² = 39%, 95% CI 0% to 81%; χ 2 = 3.27, P = 0.19).…”

Section: Resultsmentioning

confidence: 99%

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Dezocine for Preventing Postoperative Pain: A Meta-Analysis of Randomized Controlled Trials

et al. 2015

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BackgroundDezocine is considered to be an alternative medication for managing postoperative pain. The aim of this study was to assess the efficacy and safety of this drug in this regard.MethodsMedline, EMBASE and the Cochrane Central Register of Control Trials (CENTRAL) were searched to identify all randomized controlled trials (RCTs) that compare dezocine with placebo or dezocine with morphine on postoperative pain. The data were extracted and pooled using Mantel-Haenszel random effects model. Heterogeneity was tested using the I 2 statistic with values >50% and Chi2 test with P ≤ 0.05 indicating obvious heterogeneity between the studies.ResultsSeven trials evaluating 665 patients were included. The number of patients with at least 50% pain relief was increased (N = 234; RR 3.04, 95% CI 2.27 to 4.08) and physician (N = 465; RR 2.84, 95% CI 1.66 to 4.84) and patient satisfaction (N = 390; RR 2.81, 95% CI 1.85 to 4.26) were improved following the administration of dezocine compared with the placebo. The effects of dezocine were similar to those of morphine in terms of the number of patients reporting at least 50% pain relief within 2–6 h after surgery (N = 235; RR 1.29, 95% CI 1.15 to 1.46) and physician (N = 234; RR 1.18, 95% CI 0.93 to 1.49) and patient (N = 158; RR 1.33, 95% CI 0.93 to 1.92) satisfaction. While, the number of patients with at least 50% pain relief within 0–1 h after surgery increased following dezocine compared with morphine treatment (N = 79; RR 1.45, 95% CI 1.18 to 1.77). There was no difference in the incidence of postoperative nausea and vomiting (PONV) following dezocine treatment compared with the placebo (N = 391; RR 1.06, 95% CI 0.42 to 2.68) or morphine treatment (N = 235; RR 0.65, 95% CI 0.14 to 2.93).ConclusionDezocine is a promising analgesic for preventing postoperative pain, but further studies are required to evaluate its safety.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Dezocine for Preventing Postoperative Pain: A Meta-Analysis of Randomized Controlled Trials

et al. 2015

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“…Based on the above reasons, some common adverse effects of opioids are significantly reduced with this drug due to its good tolerance, mild adverse effects and good potence [1,[20][21][22]. Some studies find that Dezocine is a promising and safe analgesic that is slightly more potent than morphine for the relief of postoperative pain [1,23]. Most importantly, study indicates that Dezocine can cause a significant increase in the number of patients with at least50% pain relief during the early postoperative period (within 0-1h) compared with morphine [1], which means that Dezocine may be a good choice for postoperative pain during anesthesia recovery period.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Cardiovascular, Analgesic and Sedative Effects of Different Doses of Dezocine

Ping¹

2017

ACCMJ

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Background: Dezocine is considered to be an alternative medication for managing postoperative pain. However, no study is focused on the cardiovascular, analgesic and sedative effects of intravenous Dezocine during anesthesia recovery period after micro vascular decompression (MVD) surgery for hemi facial spasm (HS).Therefore; we provide the clinical practice on this topic. Methods: A total of 160 patients, American Society of Anesthesiologists (ASA) physical status I-II, undergoing elective MVD surgery for HS, were randomized equally into four groups. The four groups were given intravenously a matching placebo (group A) (equal volume of 0.9% saline), Dezocine 0.05 mg/kg (group B), 0.1 mg/kg (group C) and 0.2 mg/kg (group D) respectively. Mean arterial pressure (MAP) and heart rate (HR) were measured at three periods: 5minutes before anesthesia induction (T0), at the moment of pulling out laryngeal mask (LMA) (T1),10 minutes after the procedure(T2).Sedation-Agitation Scale (SAS) at T1, Visual Analogue Scale (VAS) and Modified Observers Assessment of Alertness/Sedation Scale (OAA/S)at T2 were assessed in four groups. Mean while, the incidences of respiratory depression (RD), postoperative nausea and vomiting (PONV) were also observed during anesthesia recovery period in four groups. Multivariate analysis of variance and the Pearson χ2 test were used, and a value of P< 0.05 was considered statistically significant. Results: The mean value of anesthesia recovery time was higher in group D (P<0.05 vs. group A).It indicated statistical differences (P<0.05vs. group A) in SAS and VAS at T1 in group C and in group D, the value of OAA/S indicated statistical difference (P<0.05vs. group A) at T2 in group D. It indicated significant differences (P<0.05 vs. group A) in MAPand HR at

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Zentral wirksame Analgetika vom Typ Opioid

Waldvogel¹

2001

Analgetika Antinozizeptiva Adjuvanzien

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Double-blind placebo-controlled comparison of dezocine and morphine for post-operative pain relief

Cited by 16 publications

References 12 publications

Dezocine for Preventing Postoperative Pain: A Meta-Analysis of Randomized Controlled Trials

Dezocine for Preventing Postoperative Pain: A Meta-Analysis of Randomized Controlled Trials

Comparison of Cardiovascular, Analgesic and Sedative Effects of Different Doses of Dezocine

Zentral wirksame Analgetika vom Typ Opioid

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