1988
DOI: 10.1016/0016-5085(88)90482-9
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Double-blind, placebo-controlled endoscopic comparison of the mucosal protective effects of misoprostol versus cimetidine on tolmetin-induced mucosal injury to the stomach and duodenum

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Cited by 132 publications
(45 citation statements)
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“…In endoscopic studies, misoprostol significantly prevented damage to the gastroduodenal mucosa induced b y aspirin (70)(71)(72), naproxen (73), tolmetin (32,74), ibuprofen (76) and ethanol (76). In these studies, the mucosal protective effects of misoprostol could not be explained on the sole basis of a reduction in gastric secretion.…”
Section: Mucosal Protectionmentioning
confidence: 58%
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“…In endoscopic studies, misoprostol significantly prevented damage to the gastroduodenal mucosa induced b y aspirin (70)(71)(72), naproxen (73), tolmetin (32,74), ibuprofen (76) and ethanol (76). In these studies, the mucosal protective effects of misoprostol could not be explained on the sole basis of a reduction in gastric secretion.…”
Section: Mucosal Protectionmentioning
confidence: 58%
“…Misoprostol was significantly and profoundly more potent than cimetidine, administered at an effective gastric antisecretory dose, in protecting the gastric mucosa from injury induced by tolmetin (32) and ethanol (76). These studies suggest that the inhibition of gastric acid Secretion in humans is not a significant contributor to the gastric mucosal protective effects of misoprostol, as cimetidine, at a dose which gives maximum inhibition of acid secretion, was only marginally protective (32,71). Furthermore, misoprostol was significantly more potent than sucralfate in preventing aspirin-induced injury to the gastric mucosa (77).…”
Section: Mucosal Protectionmentioning
confidence: 63%
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