Double-blind, placebo-controlled safety and efficacy trial with yohimbine hydrochloride in the treatment of nonorganic erectile dysfunction

Abstract

This double-blind, placebo-controlled clinical trial of yohimbine hydrochloride included 86 patients with erectile dysfunction and without clearly detectable organic or psychologic causes. The patient group ful®lled all entry criteria; 85 of these could be considered for the Safetyrespectively 83 for the Intention-to-treat (ITT)-analysis. Yohimbine was administered orally in a dosage of 30 mg a day (two 5mg tablets three times daily) for eight weeks. Patients were seen for follow-up after four weeks' treatment, and for a ®nal visit after eight weeks.Ef®cacy evaluation was based on both subjective and objective criteria. Subjective criteria included improvement in sexual desire, sexual satisfaction, frequency of sexual contacts, and quality of erection (penile rigidity) during sexual contact/intercourse. Objective criteria of outcome were based on improvement in penile rigidity determined by use of polysomnography in the sleep laboratory. Overall Yohimbine was found signi®cantly more effective than placebo in terms of response rate: 71 vs 45%.Yohimbine was well-tolerated: Only 7% of patients rated tolerability fair or poor, and most adverse experiences were mild. There was no serious adverse event.

Symptomatic Treatment of Multiple Sclerosis

“…Apomorphine may be less effective compared to sildenafil and its adverse effects, especially nausea and fatigue, will often limit its use. In patients suffering from psychogenic ED, yohimbine may ameliorate erection [140]. …”

Creative-dynamic image synthesis: a useful addition to the treatment options for impotence

“…12 Several authors have shown that the treatment of nonorganic ED with the alpha-2-antagonist yohimbine hydrochloride is safe and effective. 13 However, a host of organic side effects have been recorded in association with the use of yohimbine. Therefore, the question arises of whether the treatment of ED through the administration of yohimbine outweighs the risks associated with this drug.…”

The relaxant effect of methanolic extract of yohimbe bark (<i>Pausinystalia yohimbe</i>) on rabbit corpus cavernosum smooth muscles

“…These findings were supported by pervious sophisticated results which concerned with examination of yohimbine-induced relaxation in human and rabbit corpora cavernosa through interfering with NO release from the endothelium. The yohimbine-induced corpus cavernosum relaxation was inhibited by mechanical removal of the endothelium and by blocking NO formation or signaling via guanylate cyclase and cGMP formation [20][21][22][23][24][25][26][27][28].…”

“…Yohimbine was found to be beneficial and effective in treatment of psychogenic and/or organic erectile dysfunction when taken in divided daily doses [21][22][23][24][25].…”