Double-blind randomized controlled trial and six-year open follow-up of yttrium-90 radiosynovectomy versus triamcinolone hexacetonide in persistent rheumatoid knee synovitis

Grant, Eric; Bellamy, Nicholas; Fryday-Field, K.; Disney, T F; Driedger, Al; Hobby, K.

doi:10.1007/bf02735372

Cited by 18 publications

(10 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…9 Side-effects of radiosynoviorthesis, such as irradiation synovitis, can be avoided by synchronous injection of corticosteroids, 10 but we do not administer steroids with yttrium because the therapeutic effect might depend on this concomitant administration of steroids rather than the administration of yttrium alone. 11 Indications for radiosynoviorthesis are the persistent synovitis (for which ultrasonographic findings and higher blood pool in three-phase bone scintigraphy is characteristic; clinically, there are knee pains, swelling, a functional limitation) with a conservative treatment failure without reaction on the intra-articular corticosteroids.…”

Section: Discussionmentioning

confidence: 99%

Reradiosynoviorthesis of the Knee

Kraft

Kašpárek

Stępień

2005

Cancer Biotherapy and Radiopharmaceuticals

View full text Add to dashboard Cite

The aim of this study was to compare the treatment results between radiosynoviorthesis and reradiosynoviorthesis of knees. Before the radiosynoviorthesis, an ultrasonography, X-ray, and three-phase bone scintigraphy were done. The treatment effect can be expected if a synovitis is proved by these examinations. To knees, 200 MBq of the yttrium citrate was injected for the first radiosynoviorthesis or for reradiosynoviorthesis. After an application, it is possible to do the scintigraphic examination, when information about a tracer distribution in joints is obtained. The treatment effect was evaluated by the clinical examination, the ultrasonography, and the three-phase bone scintigraphy with some lapse of time. If the effect of the radiosynoviorthesis was not satisfying, it could be repeated no sooner than 6 months later. Among our patients we had a high percentage of the repeated radiosynoviorthesis. The authors applicated the yttrium citrate to 1243 knees. A rate between single radiosynoviorthesis and reradiosynoviorthesis was 11:8. Repeated radiosynoviorthesis were as effective as the initial ones, and their repeated use does not decrease the expected therapeutic effect.

show abstract

Section: Discussionmentioning

confidence: 99%

Reradiosynoviorthesis of the Knee

Kraft

Kašpárek

Stępień

2005

Cancer Biotherapy and Radiopharmaceuticals

View full text Add to dashboard Cite

show abstract

“…In Medline six papers were identified which met our inclusion criteria9 12-16 and one additional paper was identified in Embase 18. Thus seven papers were identified.…”

Section: Resultsmentioning

confidence: 99%

“…We decided not to include this study. This left five studies9 13 14 16 18 whose methodological quality was assessed by one of us (EHD). These studies are presented in chronological order (table 3).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Yttrium radiosynoviorthesis in the treatment of knee arthritis in rheumatoid arthritis: a systematic review

Heuft-Dorenbosch¹

2000

Annals of the Rheumatic Diseases

View full text Add to dashboard Cite

Objective-To consider the question: How strong is the evidence in favour of yttrium synovectomy in chronic knee arthritis in patients with rheumatoid arthritis in comparison with placebo and intraarticular steroid treatment? Methods-A systematic review of the literature was performed using Medline and the Embase database. Results-Initially, seven papers were identified, but only two met the inclusion criteria. Neither study showed evidence in favour of yttrium synovectomy. Conclusion-From the point of view of evidence based medicine it should be seriously questioned whether yttrium synovectomy deserves a place in clinical practice.

show abstract

“…Heuft-Dorenbosch et al [22] veröffentlichten 2000 eine umfangreiche Übersicht zur RSO (Evidenz-Level Ia). Die Autoren sichteten 184 Arbeiten zu dieser Thematik, von denen nach ihrer Auffassung letztlich nur fünf [1,4,6,15,50] …”

Section: Placebo-kontrollierte Studien Und Meta-analysenunclassified

Radiosynoviorthese

Seidel

DGRh²

2006

Z. Rheumatol.

View full text Add to dashboard Cite

Intraarticular therapy is an established form of therapy in chronic inflammatory joint diseases. Besides the injection of glucocorticoids, radiosynoviorthesis is a frequently used procedure. Intraarticular injected beta-emitting radionuclides are indicated in chronic synovitis with recurrent joint effusions in rheumatoid arthritis, seronegative spondyloarthritis, villonodular synovitis after surgery and for bleeding prophylaxis in haemophilic arthropathy. The value of radiosynoviorthesis in activated osteoarthritis is not yet clarified.

show abstract

Double-blind randomized controlled trial and six-year open follow-up of yttrium-90 radiosynovectomy versus triamcinolone hexacetonide in persistent rheumatoid knee synovitis

Cited by 18 publications

References 16 publications

Reradiosynoviorthesis of the Knee

Reradiosynoviorthesis of the Knee

Yttrium radiosynoviorthesis in the treatment of knee arthritis in rheumatoid arthritis: a systematic review

Radiosynoviorthese

Contact Info

Product

Resources

About