Double-Blind Study on Effects of Glucosyl Ceramide in Beet Extract on Skin Elasticity and Fibronectin Production in Human Dermal Fibroblasts

Hori, Mio; Kishimoto, Seishi; Tezuka, Yu; Nishigori, Hideo; Nomoto, Keitaro; Hamada, Umenoi; Yasuda, Yoshikazu

doi:10.3793/jaam.7.129

Cited by 27 publications

(31 citation statements)

References 23 publications

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“…The improvement in skin moisturising was statistically significant at the abdominal skin application site. The results of the present study are consistent with the literature data [37][38][39][40][44][45][46][47][48]. In particular, the results are consistent with those of Li et al [44], who also showed that the measures taken one hour of the application are predictive of the stratum corneum moisturising obtained after a multiple applications for one or 2 weeks.…”

Section: Discussionsupporting

confidence: 83%

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Tolerability and hydrating effects of an anti-aging gynaecological collagen cream in women in menopause

Stefano¹,

Radicioni²,

Vele³

et al. 2014

OJOG

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Background and Aims: A gynaecological cream containing collagen, phytocollagen, hyaluronate and vitamins was investigated in women in menopause. Methods: The cream was daily applied to the vaginal mucosa and the perineal skin as well as to the abdominal skin (healthy skin used as control) for 1 week and then on alternate days for other 2 weeks. Skin hydration and viscoelasticity were measured at baseline and after 8 and 21 days by Corneometer ® CM 825 and Cutometer ® MPA 850, respectively. The product use comfort and the moisturising of the vaginal mucosa were evaluated by the volunteers through a questionnaire and a visual analogue scale, respectively. Results: The local tolerability was excellent for nearly all of the volunteers (90% -95%) and according both to dermatologist's and gynaecologist's evaluation. Related adverse reactions had a frequency of 15% (10% vulvovaginal burning sensation and 5% vulvovaginal discomfort). The topical hydration increased both in the perineal and the abdominal skin. Hydration increase vs. baseline was more marked on day 8 than on day 21 and was significant in the abdominal skin (p-value < 0.0001). The vaginal moisturising improved significantly (p-value < 0.0001) both on day 8 and 21 vs. baseline. Small changes in the viscoelasticity parameters were observed in both the perineal and the abdominal skin. Few significant improvements were R1 and R8 decreases in the perineum and R0 increase in the abdomen. Conclusions: The tested cream represents a safe product with proven moisturising effect towards the vaginal mucosa when daily applied by menopausal women.

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Section: Discussionsupporting

confidence: 83%

“…Results obtained for perineal and abdominal skin viscoelasticity were consistent with previously published data of other similar studies [29,[45][46][47][48]. In the present study, small changes in the skin elasticity parameters were observed in both perineal and abdominal skin, but their majority did not have statistical significance.…”

Section: Discussionsupporting

confidence: 82%

Tolerability and hydrating effects of an anti-aging gynaecological collagen cream in women in menopause

Stefano¹,

Radicioni²,

Vele³

et al. 2014

OJOG

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“…The purpose of this double-blind randomized controlled human clinical trial was to test, in a rigorous way, the hypothesis that even small amounts of sphingoid base derivatives, administered orally to humans, can afford measurable and significant and perceivable benefits to the skin, as suggested by the various animal studies and a few smaller-scale human trials [9][10][11][12][13][14][15][16][17] and our own preliminary study.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, there is a slowly growing body of evidence from animal and human clinical studies that oral supplementation with ceramides may be beneficial for skin permeability barrier homeostasis [13][14][15][16][17][18] and parameters such as hydration and/or barrier function, elasticity, and recovery after induced disruption of barrier dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Improving Skin Hydration and Age-related Symptoms by Oral Administration of Wheat Glucosylceramides and Digalactosyl Diglycerides: A Human Clinical Study

Bizot¹,

Cestone²,

Michelotti³

et al. 2017

Cosmetics

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Abstract:Ceramides are known to play a key role in the skin's barrier function. An age-dependent decrease in ceramides content correlates with cutaneous clinical signs of dryness, loss of elasticity, and increased roughness. The present placebo-controlled clinical study aims to evaluate if an oral supplementation with glucosylceramides (GluCers) contained in a wheat polar lipids complex (WPLC) was able to improve such skin conditions. Sixty volunteers presenting dry and wrinkled skin were supplemented during 60 days with either a placebo or a WPLC extract in oil or powder form (1.7 mg GluCers and 11.5 mg of digalactosyldiglycerides (DGDG)). Skin parameters were evaluated at baseline and after 15, 30, and 60 days of supplementation. Oral intake of WPLC significantly increased skin hydration (p < 0.001), elasticity, and smoothness (p < 0.001), and decreased trans epidermal water loss (TEWL) (p < 0.001), roughness (p < 0.001), and wrinkledness (p < 0.001) in both WPLC groups compared to placebo. In both WPLC treated groups, all parameters were significantly improved in a time-dependent manner compared to baseline. In conclusion, this study demonstrates the positive effect of oral supplementation with GluCers on skin parameters and could reasonably reinforce the observations made on mice that orally-supplied sphingolipids can reach the skin.

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“…However, results from the present authors' previous research showed that precise measurement of AF in suntanned Asian subjects was difficult. Clinical practice in Japan is to have the subject rest his or her cheek on his or her hands and measure the AF from a 10-cm length of skin, on the back of the arm above the elbow 44) . Further data will be required to validate this method of measuring skin AF for Asian patients.…”

Section: Non-invasive Skin Ages Examination (Age Reader)mentioning

confidence: 99%

Glycation Stress and Photo-Aging in Skin

et al. 2011

Self Cite

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Reducing sugars, such as glucose in basic solutions, and lipids by β-oxidation or peroxidation generate formyl (aldehyde) and ketone groups. Aldehydes and ketones have a highly polarized carbonyl (C=O) group, the oxygen atom of which is electronegative and may react with nucleophiles in proteins. As a result, aldehydes and ketone groups may react non-enzymatically with cell proteins by glycation, and degrade protein function. Although similar reactions have been observed in vivo, we have little information on the relationship between these reactions and age-related changes in skin.Many age-related regressive changes are actually due to protein degradation, such as posttranslational modification (proteomic denaturation), accumulation of degenerated wastes, deterioration of functional proteins, functional disorder of the tricarboxylic acid (TCA) cycle, or activation of inflammatory pathways by intracellular signals 1) . All of these changes are symptomatic of "glycation stress". Review Article Glycation Stress and Photo-Aging in Skin AbstractThis article reviews glycation stress as a factor linked to age-related diseases and functional and structural alterations of the skin. Photo-aging and glycation stress are major causes of skin deterioration. Glycation occurs when a reducing sugar, such as glucose or fructose, combines with a protein in a non-enzymatic reaction forming a glycated protein. Further reactions form advanced glycation end products (AGEs), which may accumulate in tissue. AGEs may also bind to a receptor for AGEs (RAGE), thus inducing inflammatory changes in skin and other tissues. The concept of glycation stress includes cellular and tissue responses to reducing sugars and aldehydes, not just to the production of AGEs.Glycation stress may be induced and affected by many factors, including exposure to ultraviolet light, which drastically intensifies AGE accumulation. AGEs modify skin collagen by reducing skin elasticity, and one result is wrinkle formation. AGEs accumulated in skin may be detected using auto-fluorescence (AF); our data from 136 healthy Japanese females shows the AF level is correlated with age.Glycation stress, and subsequently skin aging, may be reduced by managing levels of blood glucose, low-density lipoprotein cholesterol, and triglyceride through an appropriate diet, lifestyle, and intake of anti-glycation materials such as AGE generation inhibitors, AGE decomposers, and AGE receptor antagonists. Study of glycation stress may help identify new anti-aging treatments.

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Double-Blind Study on Effects of Glucosyl Ceramide in Beet Extract on Skin Elasticity and Fibronectin Production in Human Dermal Fibroblasts

Cited by 27 publications

References 23 publications

Tolerability and hydrating effects of an anti-aging gynaecological collagen cream in women in menopause

Tolerability and hydrating effects of an anti-aging gynaecological collagen cream in women in menopause

Improving Skin Hydration and Age-related Symptoms by Oral Administration of Wheat Glucosylceramides and Digalactosyl Diglycerides: A Human Clinical Study

Glycation Stress and Photo-Aging in Skin

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