Double coating of graphene oxide–polypyrrole on silk fibroin scaffolds for neural tissue engineering

Abstract

The desired scaffolds for neural tissue engineering need to have electrical conductivity. In this study, we doubly coated graphene oxide and polypyrrole on silk fibroin scaffolds (SF@GO-PPY) by a facile method to improve its electrical conductivity. The graphene oxide–polypyrrole double coating was distributed homogeneously on silk fibroin scaffolds. Compared with silk fibroin scaffolds, the SF@GO-PPY scaffold showed higher electrical conductivity, electrochemical property, mechanical property, and thermal stability. The π–π stacking interaction between polypyrrole and graphene oxide might contribute to the superior conductive and electrochemical property of the SF@GO-PPY scaffold. Moreover, in vitro cell experiment carried out on SH-SY5Y cells showed no cytotoxicity of all the scaffolds. Thus, the results indicated that the SF@GO-PPY scaffold might be a suitable candidate for the application in neural regeneration field.

When 2D nanomaterials meet biomolecules: design strategies and hybrid nanostructures for bone tissue engineering

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Graphene-based hybrid materials as promising scaffolds for peripheral nerve regeneration

“…Several examples involving combinations of synthetic and natural polymers have been reported for peripheral and nerve regeneration. For instance, Wang et al reported recently the use of silk fibroin (SF) with PPy (Wang et al, 2020). In this study, the authors showed that PPy and GO were uniformly distributed on SF scaffolds giving rise to materials with remarkable mechanical properties, electrical conductivity and superior cytocompatibility when using SH-SY5Y cells.…”

Horseradish peroxidase‐mediated polyethylene glycol‐templated polymerisation of gallic acid and pyrrole to improve the functionalisation and dyeing properties of silk fabrics

“…The larger the area of the circular curve, the greater the electrochemical properties and the conductivity of the material are. 27…”