Double crosslinking chitosan sponge with antibacterial and hemostatic properties for accelerating wound repair

Cao, Shujun; Xu, Gan; Li, Qiujing; Zhang, Shukun; Yang, Yifan; Chen, Jingdi

doi:10.1016/j.compositesb.2022.109746

Cited by 91 publications

(25 citation statements)

References 54 publications

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“…The HR was 0.5 ± 0.2% for CB/Lid-0 group, 0.4 ± 0.3% for CB/Lid-5 group, and 0.4 ± 0.1% for CB/Lid-10 group. According to the ASTM F756-2000, HR should be no more than 5% [ 44 ]. Thus, the hemocompatibility of CB/Lid-n was proved to be excellent.…”

Section: Resultsmentioning

confidence: 99%

One-step fabrication of lidocaine/CalliSpheres® composites for painless transcatheter arterial embolization

et al. 2022

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Background Transcatheter arterial embolization (TAE) is one of the first-line treatments for advanced hepatocellular cancer. The pain caused by TAE is a stark complication, which remains to be prevented by biomedical engineering methods. Methods Herein, a commercial embolic agent CalliSpheres® bead (CB) was functionally modified with lidocaine (Lid) using an electrostatic self-assembly technique. The products were coded as CB/Lid-n (n = 0, 5, 10, corresponding to the relative content of Lid). The chemical compositions, morphology, drug-loading, and drug-releasing ability of CB/Lid-n were comprehensively investigated. The biocompatibility was determined by hemolysis assay, live/dead cell staining assay, CCK8 assay, immunofluorescence (IHC) staining assay and quantitative real-time PCR. The thermal withdrawal latency (TWL) and edema ratio (ER) were performed to evaluate the analgesia of CB/Lid-n using a plantar inflammation model. A series of histological staining, including immunohistochemistry (IL-6, IL-10, TGF-β and Navi1.7) and TUNEL were conducted to reveal the underlying mechanism of anti-tumor effect of CB/Lid-n on a VX2-tumor bearing model. Results Lid was successfully loaded onto the surface of CalliSpheres® bead, and the average diameter of CalliSpheres® bead increased along with the dosage of Lid. CB/Lid-n exhibited desirable drug-loading ratio, drug-embedding ratio, and sustained drug-release capability. CB/Lid-n had mild toxicity towards L929 cells, while triggered no obvious hemolysis. Furthermore, CB/Lid-n could improve the carrageenan-induced inflammation response micro-environment in vivo and in vitro. We found that CB/Lid-10 could selectively kill tumor by blocking blood supply, inhibiting cell proliferation, and promoting cell apoptosis. CB/Lid-10 could also release Lid to relieve post-operative pain, mainly by remodeling the harsh inflammation micro-environment (IME). Conclusions In summary, CB/Lid-10 has relatively good biocompatibility and bioactivity, and it can serve as a promising candidate for painless transcatheter arterial embolization.

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Section: Resultsmentioning

confidence: 99%

One-step fabrication of lidocaine/CalliSpheres® composites for painless transcatheter arterial embolization

et al. 2022

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“…75,76 At present, the materials commonly used in the preparation of sponge dressings are mainly natural polymers including alginate, chitosan and gelatin. 77 Excessive exudate at chronic wound sites due to inflammation-induced edema, venous or lymphatic insufficiency predisposes to wound maceration and severe bacterial infection. 19 In addition, the high concentration of proteases in the exudate of the chronic wound may cause adverse consequences such as inactivation of key cytokines, destruction of the ECM, and impaired wound healing.…”

Section: Biomaterials Science Reviewmentioning

confidence: 99%

“…75,76 At present, the materials commonly used in the preparation of sponge dressings are mainly natural polymers including alginate, chitosan and gelatin. 77…”

Section: Categories Of Multifunctional Wound Dressingsmentioning

confidence: 99%

Construction of multifunctional wound dressings with their application in chronic wound treatment

Long

Liu

et al. 2022

Biomater. Sci.

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“…In addition, the antibacterial ability of the TA-CFO/PVA group was more significant, which may be due to TA and Co 2+ synergistically inhibiting the formation of biofilms of S. aureus and E. coli, leading to the death of the bacteria. 40,41 Besides the contribution of Co 2+ to the antibacterial activity, TA also has good antibacterial effects and anti-inflammatory properties. However, previous studies found that TA could not effectively inhibit E. coli.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Tannin-bridged magnetic responsive multifunctional hydrogel for enhanced wound healing by mechanical stimulation-induced early vascularization

Wang

Zhou

et al. 2022

J. Mater. Chem. B

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Double crosslinking chitosan sponge with antibacterial and hemostatic properties for accelerating wound repair

Cited by 91 publications

References 54 publications

One-step fabrication of lidocaine/CalliSpheres® composites for painless transcatheter arterial embolization

One-step fabrication of lidocaine/CalliSpheres® composites for painless transcatheter arterial embolization

Construction of multifunctional wound dressings with their application in chronic wound treatment

Tannin-bridged magnetic responsive multifunctional hydrogel for enhanced wound healing by mechanical stimulation-induced early vascularization

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