Double Para-testicular Cellular Angiofibroma and Synchronous Testicular Microlithiasis

Lee, Seungkoo; Choi, Hyung Rim

doi:10.4132/jptm.2015.06.23

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…Nevertheless, this study did not present statistically significant results that show an increased risk of cancer in patients with microlithiasis compared to patients with normal ultrasound findings. According to several studies (8)(9)(10), there is an increased risk for the development of the testicular germ cell tumor in patients with testicular microlithiasis but in the presence of other risk factors.…”

Section: Discussionmentioning

confidence: 99%

Testicular Microlithiasis: Case Report and Literature Review

Savić¹,

Vasić²,

Petrović³

et al. 2017

Acta Facultatis Medicae Naissensis

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SU M M A RYTesticular microlithiasis is a condition characterized by the ultrasonographic findings with multiple microliths, with the prevalence of 0.6% to 9%. This is a condition of unknown etiology; however, in many cases it may be associated with cryptorchidism, Klinefelter syndrome, Down syndrome, varicocele, testicular torsion and male pseudohermaphroditism. Many retrospective studies point to the association between testicular microlithiasis and testicular cancer.We report a case of a 50-year-old patient who presented to the urologist because of dysuric symptoms. Ultrasonographic examination of both testicles revealed microcalcifications in large numbers, i.e. "the phenomenon of the starry sky". More than 20 microcalcifications were present on the cross section of both testicles. Standard laboratory blood tests were normal. Prostate-specific antigen was 1.22 ng/ml. If risk factors for developing cancer are present, some authors recommend a biopsy of the testicles. However, based on the literature review, currently, there is no a strictly defined protocol.

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Section: Discussionmentioning

confidence: 99%

Testicular Microlithiasis: Case Report and Literature Review

Savić¹,

Vasić²,

Petrović³

et al. 2017

Acta Facultatis Medicae Naissensis

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show abstract

“…Testicular microlithiasis (TM) is an uncommon condition of unknown etiology present as multiple tiny calcifications within the seminiferous tubules [1][2][3] . This sonographic finding is associated with both malignant and benign conditions such as testicular neoplasms [4,5] . Fedder stated that Doherty and colleagues were the first investigators to describe the ultrasonographic (US) appearance of TM as small, uniform nonshadowing calcifications less than 3 mm randomly scattered throughout the parenchyma of the testis [6,7] .…”

Section: Introductionmentioning

confidence: 99%

Association between testicular microlithiasis and varicocele in infertile men: A comparative study

et al. 2018

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patients [8-11]. On the contrary, Höbarth et al. [12] pointed out that the prevalence of TM in patients who underwent US owing to a variety of scrotal symptoms was 0.6%. However, this incidence has increased in the past few years owing to technological advances and raising awareness about the condition [11]. In the same vein, Pedersen et al. [13] found recently that the prevalence of TM in patients who had an US investigation of the scrotum owing to testicular/scrotal symptoms was 12.8%. Moreover, Fedder [7] demonstrated that the prevalence rate of testicular hyperechoic foci (sonographic TML= testicular microlithiasis, FSH= follicle stimulating hormone, LH= luetinizing hormone) in nonvasectomized azoospermic males is 13.4%.

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“…Testicular microlithiasis (TM) is an uncommon condition of unknown etiology with multiple tiny calcifications present within the seminiferous tubules [ 1 – 3 ], which is associated with both malignant and benign conditions such as testicular neoplasms [ 4 , 5 ]. So far no valid clinical or research approaches used to investigate the activity of TM in malignant conditions and infertility are available because of its unknown etiology.…”

Section: Introductionmentioning

confidence: 99%

Role of calcifying nanoparticles in the development of testicular microlithiasis in vivo

Lin

Gao

et al. 2017

BMC Urol

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BackgroundCalcifying nanoparticles (NPs) have been proven to be associated with a variety of pathological calcification and previously detected in semen samples from patients with testicular microlithiasis (TM). The present study was designed to test the hypothesis if human-derived NPs could invade the seminiferous tubules and induce TM phenotype.MethodsThe animals were divided into three groups. Normal saline (0.2 mL) was injected into the proximal right ductus deferens in group A as a control group. The experimental groups, B and C received Escherichia coli (106 cfu/mL, 0.2 mL) and human-derived NPs suspension (0.2 mL), respectively. Rats were euthanized in 2 batches at 2 and 4 weeks. Testicular pathology, ultrastructure and inflammatory mediators were assessed.ResultsChronic inflammatory changes were observed at 2 weeks in both groups B and C. Moreover, the innermost layer of sperm cells were structurally impaired and a zone of concentrically layered collagen fibers around the human NPs body was formed in the lumen of the seminiferous tubule in group C only, in which TM phenotype of remarkable calcification surrounded by cellular debris within the seminiferous tubules was built at 4 weeks.ConclusionsThe results obtained from our study suggested a potential pathogenic effect of NPs in the development of calcification within the seminiferous tubules, which should be addressed in the future studies.

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Double Para-testicular Cellular Angiofibroma and Synchronous Testicular Microlithiasis

Cited by 4 publications

References 8 publications

Testicular Microlithiasis: Case Report and Literature Review

Testicular Microlithiasis: Case Report and Literature Review

Association between testicular microlithiasis and varicocele in infertile men: A comparative study

Role of calcifying nanoparticles in the development of testicular microlithiasis in vivo

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