Double-salting out assisted liquid–liquid extraction (SALLE) HPLC method for estimation of temozolomide from biological samples

Jain, Darshana; Athawale, Rajani; Bajaj, Amrita; Shrikhande, Shruti

doi:10.1016/j.jchromb.2014.02.031

Cited by 22 publications

(23 citation statements)

References 20 publications

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“…(21) yields accurate values for V ∞ salt -for pure water our results agree well with reported literature values [78] (see Supporting Information) -the resulting expression for the refractive index with these two fitting parameters is rather cumbersome; there is no advantage to using the full expression Eq. (20). For low salt concentrations (x salt < 0.04), both the volume and the refractive data exhibit very good linearity with x salt .…”

Section: Theorymentioning

confidence: 81%

“…(22) into Eq. (20) and expanding the resulting expression to linear order in x salt , we obtain the following simplified expression for low salt concentration:…”

Section: Theorymentioning

confidence: 99%

“…[16,17] Therefore, some solutions, whose properties are otherwise difficult to measure directly, can be more easily identified by knowing their n values. With many current and potential applications of solvent mixtures in analytical chemistry [18][19][20] and industrial processes [21][22][23][24], such as the design of biological environments [22,23] and the search for greener liquid media, [24] the subject is receiving renewed interest both theoretically [25][26][27][28] and experimentally. [29][30][31][32][33][34][35] The refractive index reflects the polarization of the molecules by the electromagnetic field of the light.…”

Section: Introductionmentioning

confidence: 99%

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Combined Theoretical and Experimental Study of Refractive Indices of Water–Acetonitrile–Salt Systems

Zhuang

et al. 2015

J. Phys. Chem. B

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We propose a simple theoretical formula for describing the refractive indices in binary liquid mixtures containing salt ions. Our theory is based on the Clausius-Mossotti equation; it gives the refractive index of the mixture in terms of the refractive indices of the pure liquids and the polarizability of the ionic species, by properly accounting for the volume change upon mixing. The theoretical predictions are tested by extensive experimental measurements of the refractive indices for water-acetonitrile-salt systems for several liquid compositions, different salt species, and a range of salt concentrations. Excellent agreement is obtained in all cases, especially at low salt concentrations, with no fitting parameters. A simplified expression of the refractive index for low salt concentration is also given, which can be the theoretical basis for determination of salt concentration using refractive index measurements.

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Section: Theorymentioning

confidence: 81%

“…(22) into Eq. (20) and expanding the resulting expression to linear order in x salt , we obtain the following simplified expression for low salt concentration:…”

Section: Theorymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Combined Theoretical and Experimental Study of Refractive Indices of Water–Acetonitrile–Salt Systems

Zhuang

et al. 2015

J. Phys. Chem. B

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“…Few methods based on LC-UV [256][257][258][259][260][261] and LC-MS [262][263][264][265][266] were reported for the analysis of triazene compounds and procardazine in biological matrices. An LOQ of 0.5 ng mL −1 was achieved for the analysis of dacarbazine 266 and procarbazine 265 in plasma samples by LC-MS. Lower sensitivity (LOQ of 50 ng mL −1 ) was reached with LC-MS for the temozolomide assay in plasma.…”

Section: 233-237mentioning

confidence: 99%

Antineoplastic drugs and their analysis: a state of the art review

Guichard

Guillarme

Bonnabry

et al. 2017

Analyst

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The number of patients suffering from cancer is constantly increasing and, consequently, the number of different chemotherapy treatments administered is increasing. Given the high reactivity and toxicity of antineoplastic drugs, analytical methods are required in all pharmaceutical fields, from drug development to their elimination in wastewater; including formulation quality control, environment and human exposure and therapeutic drug monitoring. The aim of this paper is to provide an overview of the analytical methods available for the determination of antineoplastic drugs in different matrices such as pharmaceutical formulations, biological and environmental samples. The applicability and performance of the reported methods will be critically discussed, with focus on the most commonly used antineoplastic drugs. Only conventional compounds and small molecules for targeted therapy will be considered in the present review.

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“…The method is simple, fast, cheap and environmentally friendly and its extract is also compatible with HPLC/LC, CE and/or GC instruments [36,37]. SALLE has been applied for extraction of various organic compounds including α-dicarbonyl compounds in beer [24] and wines [25]; biogenic amines in fruit juices and alcoholic beverages [26]; N-nitrosamines in skin care cosmetics [27]; trimetazidine in rat plasma [28]; methoxetamine in rat tissues (rat brain, liver and lungs) [29]; sulfonamides from different matrices (tea, water, milk, honey, human urine, plasma and blood) [30,31]; temozolomide from plasma [32]; vitamin K homologues in human plasma [33]; multi-mycotoxin biomarkers in pig urine [34]; betalactam antibiotics in infant dairy products [35]; benzimidazole fungicides [36]; sulfonylurea herbicides in water and banana juice samples [37]; triazole pesticides in water samples [38]; multiresidue pesticides in surface, ground and drinking water [39]; and chlorophenols in wine [40]. However, to date there is no report on the use of SALLE procedure in combination with HPLC-UV/Vis for analysis of multiclass pesticide residues in alcoholic beverages.…”

Section: Introductionmentioning

confidence: 99%

Salting-out Assisted Liquid-Liquid Extraction for the Determination of Multiresidue Pesticides in Alcoholic Beverages by High Performance Liquid Chromatography

Bedassa¹

2017

SJAC

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Abstract:A salting-out assisted liquid-liquid extraction (SALLE) method followed by high-performance liquid chromatography with ultraviolet-visible detector (HPLC-UV/Vis) has been proposed for determination of five multiclass pesticides residues including, atrazine, ametryn, terbutryn, carbaryl and chlorothalonil from various alcoholic beverages: beer, wine and Ethiopian honey wine (Tej). Experimental parameters influencing the extraction efficiency of the method such as the type and concentration of salt, volume of acetonitrile (the extraction solvent) and pH of the sample were assayed and the optimum conditions were established. Under the optimum experimental conditions, matrix-matched calibration curves were constructed using beer sample as the representative matrix and good linearity over wide concentration ranges were obtained with coefficient of determination (r 2 ) of 0.997 or better. The limits of detection (LOD) and quantification (LOQ) of the method, which were determined as 3 and 10 times a signal-to-noise ratio (S/N), were in the ranges of 1.3-3.9 and 4.5-12.8 µg L -1 , respectively. Precisions studied in terms of repeatability and intermediate precision (with-in lab reproducibility) at two concentration levels have demonstrated acceptable %RSD values, which were less than 10% in both cases. The applicability of the method was also investigated by analyzing various alcoholic beverages and demonstrated satisfactory recoveries in the ranges of 71-104% with their corresponding %RSDs less than 10% in all cases. The results of the study revealed that the developed SALLE method is selective and efficient sample preparation procedure prior to quantitative analysis of the target analytes by HPLC-UV/Vis.

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Double-salting out assisted liquid–liquid extraction (SALLE) HPLC method for estimation of temozolomide from biological samples

Cited by 22 publications

References 20 publications

Combined Theoretical and Experimental Study of Refractive Indices of Water–Acetonitrile–Salt Systems

Combined Theoretical and Experimental Study of Refractive Indices of Water–Acetonitrile–Salt Systems

Antineoplastic drugs and their analysis: a state of the art review

Salting-out Assisted Liquid-Liquid Extraction for the Determination of Multiresidue Pesticides in Alcoholic Beverages by High Performance Liquid Chromatography

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