Double-Track Electrochemical Green Approach for Simultaneous Dissolution Profiling of Naproxen Sodium and Diphenhydramine Hydrochloride

Shehata, Mohamed; Fawaz, Esraa M.; El-Rahman, Mohamed K. Abd; Abdel-Moety, Ezzat M.

doi:10.1016/j.jpba.2017.08.041

Cited by 13 publications

(4 citation statements)

References 20 publications

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“…Various analytical techniques have been exploited to DIPH determination either in single or mixture forms in pharmaceutical formulations and biological fluids including chromatography [9][10][11], spectrophotometry [12][13][14], capillary electrophoresis [15][16][17], and voltammetry [18,19]. Yet few ion selective electrodes potentiometric methods are reported [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

A Reliable Electrochemical Sensor Based on Functionalized Magnetite Nanoparticles for Over‐the‐counter Allergy Medication Abuse Sensing in Biological Fluids

et al. 2021

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Diphenhydramine (DIPH) has become one of the world's most widely abused over-the-counter medications. In addition to relieving allergy symptoms, it is also recognized for causing elevated energy and mild euphoric effects. The U.S. Food and Drug Administration (FDA) has recently warned about serious problems at high doses including heart problems, seizures, coma or even death among addicted teenagers. Herein, a simple, cost-effective, and reliable nanocomposite based electrochemical sensor was designed for DIPH quantification in biological fluids. Introducing the functionalized Fe 3 O 4 nanoparticles (NPs) into the inner-filling solution and the PVC-based ion sensing membrane has been employed and compared to the classical potentiometric approach. The nanoparticles were incorporated to endorse in situ cooperative ion-pairing interaction between the ionophore and DIPH, and to improve the selectivity and detection limit (9.5 × 10 À 8 M). Nernstian potentiometric response was achieved for DIPH over the concentration range of 1.0 × 10 À 7 to 1.0 × 10 À 2 M with a slope of 59.0 � 0.2 mV/decade. Inherent merits of the proposed sensor include fast response time (6 s), superior stability (60 days) with higher sensitivity and selectivity towards DIPH without interference from co-formulated drugs and several ions commonly found in biological matrices. The proposed sensor was successfully applied to the potentiometric determination of DIPH in different biological fluids (plasma and human milk) with an average recovery of 99.06 � 1.95 % and 100.34 � 1.92 %, respectively. As a consequence, the developed ISE might be the ideal choice for in-line DIPH measurements in plasma samples to identify overdose ingestion and its related symptoms, as well as for quality-control laboratories without prior treatments.

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Section: Introductionmentioning

confidence: 99%

A Reliable Electrochemical Sensor Based on Functionalized Magnetite Nanoparticles for Over‐the‐counter Allergy Medication Abuse Sensing in Biological Fluids

et al. 2021

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“…[1][2][3][4][5] Dissolution testing is a vital analytical tool that is either used in quality control to ensure batch to batch uniformity or in research and development laboratories to predict the in vivo performance of orally administered solid formulations. [6][7][8][9][10] For this purpose, several dissolution media have been introduced as a tool for in vitro biorelevant dissolution. These media compositions approximately resemble both the pre-and postprandial states in the stomach and the upper small intestine aiming to approach the physiological condition regarding parameters such as pH, surface tension, buffer capacity, osmolality and viscosity.…”

mentioning

confidence: 99%

A Screen-Printed Potentiometric Sensor for Stability Indicating Assay and Real-Time Monitoring of Trospium Chloride Dissolution Profile in its Pharmaceutical Dosage Form

Salam

Ramadan

Rahman

et al. 2023

J. Electrochem. Soc.

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According to FDA guidance, a biowaiver concept declares that dissolution testing could be approved as a replacement strategy for bioequivalence studies and/or in vivo bioavailability. From the analytical chemistry standpoint, the shift from the classically developed offline methods to the highly integrated miniaturized inline analyzers is one of the pioneering ways that would modernize future of in-vitro - in-vivo correlation (IVIVC). The emergence of screen-printed electrodes (SPE) is now making the move from successive sampling steps and off-line measurements to real-time and in-line monitoring. Recently, “SPE” potentiometric sensor was presented as real-time analyzer that can offer similar analytical results as separation-based chromatographic techniques. Thus, the main objective of this paper is to design a real-time SPE for in-situ monitoring of the dissolution of trospium chloride in neutral media. Validation of the proposed sensor was performed according to the IUPAC commendations. The measurements performed with this sensor showed an accuracy of average recovery 100.50 % and standard deviation of less than 1.0%, also the repeatability and intermediate electrode variabilities were less than 1.0 and 1.3%, respectively. The developed sensor was successfully used for direct observation of the dissolution profile without any need for an extraction step or sample preparation.

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“…In addition, ISEs allowed the simultaneous monitoring of the dissolution profiles of the active substances present in the formulation through in-line potentiometric sensing. 3 Furthermore, ISEs opened more avenues for many possible pharmaceutical applications including in vivo unraveling of the possible kinetics of biological substances degradation and profiling of impurities present in APIs either from degradation or synthesis process. 4,5 However, there have been several shortage points which limit their application including the sensitivity to evaporation of their inner filling solutions, delamination or perforation of the ion sensing membrane and a need to cautious handling and maintenance.…”

mentioning

confidence: 99%

Stable Solid-State Microfabricated Potentiometric Sensor Based on Chitosan- Prussian Blue Nanocomposite Film for Amlodipine Selective Detection

Fayez¹,

Mahmoud²,

Nebsen³

et al. 2021

J. Electrochem. Soc.

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Solid state ion-selective electrodes have a grown importance in advanced detection techniques especially with exploiting different solid contact transducing substances. Nowadays, various approaches focus on producing simple, sensitive, durable and significantly stable electrodes. Lower cost of production could be achieved by employing simple, economical and efficient materials in their fabrication. Herein, a solid state microfabricated copper electrode was firstly designed from a reasonably priced and easily fabricated copper printed circuit boards followed by applying chitosan-Prussian blue nanocomposite layer. Finally, amlodipine sensing membrane was added resulting in construction of an amlodipine sensing microfabricated solid-state electrode. The designed electrode was characterized by being miniaturized, durable, portable, easily fabricated, affordable and highly stable over 60 d with a potential drift value of 600 μV h−1. The microfabricated electrode revealed promising results upon the direct analysis of amlodipine besylate and the responses showed a good linear Nernstian pattern in the dynamic range of 1.0 ×10−5.5 to 1.0 ×10−3 mol l−1 with a slope of 55.1 mV/decade. The detection limit was found to be 2.0 ×10−6 mol l−1. Selective determination of the drug was successfully achieved in presence of its degradation product without any sample preparation steps.

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Double-Track Electrochemical Green Approach for Simultaneous Dissolution Profiling of Naproxen Sodium and Diphenhydramine Hydrochloride

Cited by 13 publications

References 20 publications

A Reliable Electrochemical Sensor Based on Functionalized Magnetite Nanoparticles for Over‐the‐counter Allergy Medication Abuse Sensing in Biological Fluids

A Reliable Electrochemical Sensor Based on Functionalized Magnetite Nanoparticles for Over‐the‐counter Allergy Medication Abuse Sensing in Biological Fluids

A Screen-Printed Potentiometric Sensor for Stability Indicating Assay and Real-Time Monitoring of Trospium Chloride Dissolution Profile in its Pharmaceutical Dosage Form

Stable Solid-State Microfabricated Potentiometric Sensor Based on Chitosan- Prussian Blue Nanocomposite Film for Amlodipine Selective Detection

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