Stable Solid-State Microfabricated Potentiometric Sensor Based on Chitosan- Prussian Blue Nanocomposite Film for Amlodipine Selective Detection

Abstract

Solid state ion-selective electrodes have a grown importance in advanced detection techniques especially with exploiting different solid contact transducing substances. Nowadays, various approaches focus on producing simple, sensitive, durable and significantly stable electrodes. Lower cost of production could be achieved by employing simple, economical and efficient materials in their fabrication. Herein, a solid state microfabricated copper electrode was firstly designed from a reasonably priced and easily fabricated copper printed circuit boards followed by applying chitosan-Prussian blue nanocomposite layer. Finally, amlodipine sensing membrane was added resulting in construction of an amlodipine sensing microfabricated solid-state electrode. The designed electrode was characterized by being miniaturized, durable, portable, easily fabricated, affordable and highly stable over 60 d with a potential drift value of 600 μV h−1. The microfabricated electrode revealed promising results upon the direct analysis of amlodipine besylate and the responses showed a good linear Nernstian pattern in the dynamic range of 1.0 ×10−5.5 to 1.0 ×10−3 mol l−1 with a slope of 55.1 mV/decade. The detection limit was found to be 2.0 ×10−6 mol l−1. Selective determination of the drug was successfully achieved in presence of its degradation product without any sample preparation steps.

Design of Green Polypyrrole-based Solid-contact Ion-selective Sensors for Determination of Antihypertensive Drugs in Combined Dosage Forms and Spiked Human Plasma

“…1a) in its structure with a pKa = 9.43, accordingly it behaves as a mono-cationic species in neutral and acidic conditions. 44 This finding indicates that a cation exchanger; K-TpCPB was that kind of choice in fabrication of AML sensors. While, VAL which is tetrazole derivative, comprises an acid (pKa = 4.73) and carboxylic (pKa = 3.9) groups (Fig.…”

Design of screen-printed potentiometric platform for sensitive determination of mirabegron in spiked human plasma; molecular docking and transducer optimization

“…The pH of the working solutions is a very critical factor to achieve complete drug ionization. 29 Fig. 7 showed the effect of pH on the response of the most stable electrode (GNP SP sensor VII) over a pH range of 2–10 to achieve the optimum experimental conditions.…”

Utilization of Localized Surface Plasmon Resonance of Silver Nanoparticles for ‎the Spectrophotometric Estimation of Amlodipine and Hydrochlorothiazide

“…A portable reflective absorbance spectrophotometric smartphone device determined AM by chargetransfer complex with picric acid 11 . An electroanalytical method based on a chitosan-Prussian blue nanocomposite membrane potentiometric sensor was developed to determine amlodipine selectively 12 . Additional spectrophotometric methods for assessing AM in combination with other drugs have been published and proposed [13][14][15][16] .…”