Down-Regulated CUEDC2 Increases GDNF Expression by Stabilizing CREB Through Reducing Its Ubiquitination in Glioma

Liu, Xinfeng; Tang, Chuanxi; Zhang, Lin; Tong, Shuyan; Wang, Yue; Abdulrahman, Ayanlaja Abiola; Ji, Guangquan; Gao, Yue; Gao, Dayong; Zhang, Baole

doi:10.1007/s11064-020-03140-w

Cited by 7 publications

(2 citation statements)

References 37 publications

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“…TRIM21 mediates the degradation of the tumor suppressor, CCAAT/enhancer-binding protein alpha (C/EBPa), leading to lung cancer proliferation (141). Glial cell line-derived neurotrophic factor (GDNF) promotes glioma development and progression, and TRIM21-mediated cAMP response element-binding protein (CREB) ubiquitination decreases the transcription of GDNF and inhibits glioma genesis and development (142).…”

Section: Prospectsmentioning

confidence: 99%

The emerging roles of TRIM21 in coordinating cancer metabolism, immunity and cancer treatment

et al. 2022

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Tripartite motif containing-21 (TRIM21), an E3 ubiquitin ligase, was initially found to be involved in antiviral responses and autoimmune diseases. Recently studies have reported that TRIM21 plays a dual role in cancer promoting and suppressing in the occurrence and development of various cancers. Despite the fact that TRIM21 has effects on multiple metabolic processes, inflammatory responses and the efficacy of tumor therapy, there has been no systematic review of these topics. Herein, we discuss the emerging role and function of TRIM21 in cancer metabolism, immunity, especially the immune response to inflammation associated with tumorigenesis, and also the cancer treatment, hoping to shine a light on the great potential of targeting TRIM21 as a therapeutic target.

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Section: Prospectsmentioning

confidence: 99%

The emerging roles of TRIM21 in coordinating cancer metabolism, immunity and cancer treatment

et al. 2022

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“…The ligand-binding component of GDNF is a glycosyl-phosphatidylinositol-anchored GDNF family receptor a 1 (GFRa1), which is a well-characterized oncogene that only associates with its transmembrane co-receptor rearranged during transfection (RET) following ligand binding (13,14). Elevated GDNF expression enhances RET activation, which is crucial for the development and progression of gliomas (12,(15)(16)(17)(18). The ERK pathway is one the most important signaling cascades among all MAPK signal transduction pathways, which is required for RET induced proliferation (19) and lipid metabolism (20).…”

Section: Introductionmentioning

confidence: 99%

GDNF regulates lipid metabolism and glioma growth through RET/ERK/HIF‑1/SREBP‑1

Wang

et al. 2022

Int J Oncol

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Cancer cells rewire their metabolism to meet the demands of growth and survival and this metabolic reprogramming has been recognized as an emerging hallmark of cancer. However, the respective mechanisms remain elusive and the contribution of aberrant lipid metabolism to the malignant phenotypes of glioma are unclear. The present study demonstrated that glial-derived neurotrophic factor (GDNF) is highly expressed in glioma and associated with poor clinical outcomes. In addition, there was a significant correlation between GDNF/rearranged during transfection (RET)/ERK signaling and sterol regulatory element-binding protein-1 (SREBP-1) expression in glioma cells. Pharmacological or genetic inhibition of GDNF-induced RET/ERK activity downregulated SREBP-1 expression and SREBP-1-mediated transcription of lipogenic genes. Additionally, GDNF regulated SREBP-1 activity by promoting hypoxia-inducible factor-1α (HIF-1α) mediated glucose absorption and hexosamine biosynthetic pathway mediated SREBP cleavage-activating protein N-glycosylation. In addition, the inhibition of SREBP-1 reduced the in vitro GDNF-induced glioma cell proliferation. The results elucidated the complex relationship between GDNF/RET/ERK signaling and dysregulated glycolipid-metabolism, which shows great potential to uncover novel metabolic vulnerabilities and improve the efficacy of targeted therapies.

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GDNF Promotes Astrocyte Abnormal Proliferation and Migration Through the GFRα1/RET/MAPK/pCREB/LOXL2 Signaling Axis

et al. 2022

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Down-Regulated CUEDC2 Increases GDNF Expression by Stabilizing CREB Through Reducing Its Ubiquitination in Glioma

Cited by 7 publications

References 37 publications

The emerging roles of TRIM21 in coordinating cancer metabolism, immunity and cancer treatment

The emerging roles of TRIM21 in coordinating cancer metabolism, immunity and cancer treatment

GDNF regulates lipid metabolism and glioma growth through RET/ERK/HIF‑1/SREBP‑1

GDNF Promotes Astrocyte Abnormal Proliferation and Migration Through the GFRα1/RET/MAPK/pCREB/LOXL2 Signaling Axis

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