Down regulation of miR-143 promotes radiation – Induced thymic lymphoma by targeting B7H1

Zhao, Hainan; Cheng, Ying; Dong, Suhe; Du, Jicong; Gao, Fu; Sun, Ding; Cui, Jianguo; Jin, Ning; Cai, Jianming

doi:10.1016/j.toxlet.2017.07.891

Cited by 8 publications

(9 citation statements)

References 35 publications

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“…MicroRNAs are considered to be one of the major factors involved in the post-transcriptional regulation of genes. Studies have shown that PD-L1 expression is directly regulated by several microRNAs, such as miR-200 [14], miR-143 [15], miR-138 [16], miR-142-5p [17] and miR-34 [18]. In our comparative study on the expression level of miR-145, we confirmed that it was four times lower in cisplatin-treated A2780cis cells than in untreated A2780cis cells using real-time PCR analysis.…”

Section: Discussionsupporting

confidence: 77%

“…The expression of PD‐L1 has been found to be directly regulated by a variety of microRNAs, thus influencing the pathological processes of tumor development. More specifically, the miR‐200 family suppresses PD‐L1 in epithelial–mesenchymal transition (EMT) in lung cancer cells ; miR‐143 down‐regulation promotes radiation‐induced thymic lymphoma by targeting PD‐L1 ; up‐regulation of miR‐138 facilitates colorectal cancer cell viability and invasion via targeting PD‐L1 ; and miR‐142‐5p represses PD‐L1 expression in tumor cells, thereby enhancing anti‐tumor immunity . Protein p53 targeting PD‐1/PD‐L1 signaling by miR‐34 plays a critical role in tumor immune evasion of non‐small cell lung cancer (NSCLC) .…”

Section: Introductionmentioning

confidence: 99%

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Cisplatin-mediated down-regulation of miR-145 contributes to up-regulation of PD-L1 via the c-Myc transcription factor in cisplatin-resistant ovarian carcinoma cells

Sheng

Zhang

Wang

et al. 2019

Clinical and Experimental Immunology

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Summary Immune tolerance is one of the leading causes of chemotherapy resistance in carcinoma cases. Studies have shown that programmed cell death ligand‐1 (PD‐L1), an inhibitory molecule expressed by cancer cells, plays a significant role in immune tolerance through the induction of T cell dysfunction. The results of our RNA sequencing in previous studies revealed that microRNA‐145 (miR‐145), which is known to be down‐regulated by cisplatin in cisplatin‐resistant ovarian cancer cells, also represses gene PD‐L1 expression. However, the mechanism by which miR‐145 contributes to regulate PD‐L1 expression in cisplatin resistance of ovarian cancer is yet to be fully understood. Here, we show that cisplatin‐mediated miR‐145 down‐regulation increased PD‐L1 expression via targeting the c‐Myc transcription factor, thereby inducing T cell apoptosis in vitro. We also report that expression of miR‐145 is negatively correlated with PD‐L1 expression in human ovarian cancer tissues, malignant grades and the recurrent risks of ovarian cancer after chemotherapy. In summary, our findings suggest that the miR‐145/c‐Myc/PD‐L1 axis contributes to cisplatin resistance in ovarian cancer and support that miR‐145 might act as an adjuvant therapeutic target in chemotherapy of ovarian cancer.

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Section: Discussionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Cisplatin-mediated down-regulation of miR-145 contributes to up-regulation of PD-L1 via the c-Myc transcription factor in cisplatin-resistant ovarian carcinoma cells

Sheng

Zhang

Wang

et al. 2019

Clinical and Experimental Immunology

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“…This suggests that B7-H1 and B7-H3 molecules could be potential warning molecules involved in initiating immune escape and causing CRC (8,21,23). These two molecules continue to be expressed as the tumor progresses, but the B7-H4 molecule only exerted negative regulation during the tumor immune escape phase (24). Therefore, B7-H1 and B7-H3 molecules might be potential targets for the early diagnosis and prevention of tumors, and the intervention of B7-H4 molecules is more likely to provide a new strategy for biological targeted therapy in CRC (22,25).…”

Section: Discussionmentioning

confidence: 99%

Expression and clinical significance of negative costimulatory molecules B7-H1, B7-H3 and B7-H4 in the process of colorectal cancer’s evolution

Qiu¹,

Wu²,

Wang³

et al. 2018

Transl. Cancer Res

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Background: We made investigations on the expression of negative costimulatory molecules B7-H1, B7-H3, B7-H4 in lesions at various stages of human colorectal cancer (CRC) evolution. We also analyzed the relevance between its expression in CRC and pathological factors in clinic and patient survival time.We finally made a result that we can ensure the clinical significance of B7-H3, B7-H4 expression and the relationship between the B7 family molecules expression.Methods: All stages of CRC were collected, including polyps, adenomas, high-grade neoplasms, and colorectal carcinomas. There were 98 cases of resected CRC tissue, 30 cases of polyps, 30 cases of adenomas, and 25 cases of high-grade neoplasia. Then analysis the expression of three negative costimulatory molecules in all stages of colorectal tissue expression patterns, flow cytometry CD3 + T lymphocytes B7 family molecules to explore the potential value of their expression.Results: The expression of B7 family molecules in 30 cases of polyps, 30 cases of adenomas, 25 cases of highgrade neoplasia, and 98 cases of CRC tissues revealed that the B7-H1 and B7-H3 expression quantity was found in polyps, adenomas, high-grade neoplasms, as well as they were highly expressed in cancerous tissues. B7-H4 was only expressed in cancerous tissues. In the TNM stage of tumor progression, three negative costimulatory molecules were mainly expressed in the cytoplasm of tumor cells. In CRC in lymphocytes B7-H4 expression was related to patient age, mucinous adenocarcinoma, and lymph node metastasis. Survival analysis showed in CRC it was statistically significant that that the expression of B7-H3 and the survival rate of patients. We found that 92.9% of CRC patients expressed B7 family negative costimulatory molecules in varying degrees, and the prognosis and co-expression of B7 family negative co-stimulatory molecules were negatively correlated.Conclusions: Costimulatory molecules B7-H1, B7-H3 were expressed on the early stage of CRC development. The amount of CD3 + T lymphocyte infiltration in CRC was positively correlated with the survival of patients. They are the earliest molecules to participate in the progress of CRC developing in B7 family negative molecules. This suggests that B7-H1 and B7-H3 are involved in rectal carcinoma at the junction, as well as it is essential throughout the entire evolutionary process. However, it is in CRC tissues that B7-H4 only get expressed, and different expression patterns may have different clinical significances.

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“…Several studies have reported changes in IR-induced miRNA expression profiling [ [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] ]. Based on previous papers, a list of miRNAs that are induced or decreased in response to IR was compiled ( Table 1 ) [ [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] ].…”

Section: Introductionmentioning

confidence: 99%

Targeting miR-5088-5p attenuates radioresistance by suppressing Slug

Seok

Choi

et al. 2023

Non-coding RNA Research

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Down regulation of miR-143 promotes radiation – Induced thymic lymphoma by targeting B7H1

Cited by 8 publications

References 35 publications

Cisplatin-mediated down-regulation of miR-145 contributes to up-regulation of PD-L1 via the c-Myc transcription factor in cisplatin-resistant ovarian carcinoma cells

Cisplatin-mediated down-regulation of miR-145 contributes to up-regulation of PD-L1 via the c-Myc transcription factor in cisplatin-resistant ovarian carcinoma cells

Expression and clinical significance of negative costimulatory molecules B7-H1, B7-H3 and B7-H4 in the process of colorectal cancer’s evolution

Targeting miR-5088-5p attenuates radioresistance by suppressing Slug

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