Down-regulation of miRNA-30c predicts poor prognosis in Colorectal Cancer patients

Liu, Bin; Zhang, Meng; Liu, Lixia; Zang, Aimin; Yang, Hua; Shang, Yue; Yang, Yang; Gao, Feng; Liu, Bo; Zhang, Yonggang; Tian, Huiping

doi:10.1515/rrlm-2016-0037

Cited by 5 publications

(7 citation statements)

References 19 publications

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“…Exciting new technologies and thousands of listing examples of various miRNAs that have been identified as potential biomarkers, outbreak current scientific publications. In previous issues of the Romanian Journal of Laboratory Medicine some miRNA-30c and miRNA-190 were presented with prognostic abilities in patients with colon and lung cancer, but also a series of miRNAs that can serve as biomarkers for the evaluation of the critically ill polytrauma patient respectively (28)(29)(30). However, there is still a long way to go for the analytical and clinical validation of these classes of biomarkers.…”

Section: The Importance Of Liquid Biopsies For Precision Medicinementioning

confidence: 99%

Laboratory medicine in the era of precision medicine – dream or reality?

Dobreanu

Oprea

2019

Revista Romana De Medicina De Laborator

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Section: The Importance Of Liquid Biopsies For Precision Medicinementioning

confidence: 99%

Laboratory medicine in the era of precision medicine – dream or reality?

Dobreanu

Oprea

2019

Revista Romana De Medicina De Laborator

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“…Tumor growth was associated with the downregulation of 14 miRs reported in 13 studies: miR-302c 67 , miR-466 68 , let-7a-5p 98 , miR-132 99 , miR-206 100 , miR-33b 76 , miR-154 78 , miR-194 80 , miR-100 81 , miR-378 101 , miR-378a-3p 58 , miR-378a-5p 58 , miR-148b 102 and miR-30c 103 . Ten studies verified the upregulation of miR-1296 84 , miR-193a-3p 104 , miR-592 90 , miR-720 91 , miR-210 93 , miR-182 44 , miR-429 105 ,miR-125b 66 and miR-21 26, 28 associated with tumor growth as well.…”

Section: Resultsmentioning

confidence: 92%

“…A total of 32 studies demonstrated the association between the downregulation of 32 miRs and the presence of lymph node metastasis such as miR-6852 106 , miR-302c 67 , miR-466 68 , miR-340 69 , miR-944 71 , miR-30d 72 , miR-22 50 , miR-296 73 , miR-199b 47 , let-7a-5p 98 , miR-132 99 , miR-497 107 , miR-206 100 , miR-128 75 , miR-154 78 , miR-149 79 , miR-24-3p 54 , miR-15a 34 , miR-16 34, 36 , miR-193a-5p 108 , miR-100 81 , miR-133a 41 , miR-205 109 , miR-335 82 , miR-378 101 , miR-218 83 , miR-138 110 , miR-625 111 , miR-212 112 , miR-195 113 , miR-133b 37 and miR-30c 103 . Other 30 studies verified the upregulation of miR-1296 84 , miR-200c 114 , miR-21 26, 29 , miR-130a 85 , miR-7 55 , miR-96 86 , miR-1260b 115 , miR-517a 87 , miR-106b 88 , miR-320e 89 , miR-196a 57 , miR-196b 57 , miR-376a 116 , miR-720 91 , miR-494 61 , miR-630 92 , miR-181a 31 , miR-20a 62 , miR-210 93 , miR-182 43, 44 , miR-25 94 , miR-191 95 , miR-183 46 , miR-199a-3p 117 , miR-429 105 , miR-92a 96 , miR-10b 118 , miR-155 30 and miR-552 97 associated with the presence of lymph node metastasis.…”

Section: Resultsmentioning

confidence: 99%

“…Among the evaluated studies, 49 demonstrated the downregulation of miR-199b 47, 48 , miR-6852 106 , miR-302c 67 , miR-466 68 , miR-650 123 , miR-196b-5p 70 , miR-944 71 , miR-30d 72 , miR-296 73 , miR-187 124 , let-7a-5p 98 , miR-132 99 , miR-206 100 , miR-148a 125 , miR-33b 76 , miR-99b-5p 120 , miR-154 78 , miR-217 126 , miR-149 79 , miR-194 80 , miR-7 56 , miR-24-3p 54 , miR-29b 127 , miR-15a 34 , miR-16 34, 36 , miR-204-5p 128 , miR-96-5p 121 , miR-193a-5p 108 , miR-100 81 , miR-133a 41 , miR-139-5p 129 , miR-124-5p 130 , miR-335 82 , miR-378 101 , miR-126 40 , miR-378a-3p 58 , miR-378a-5p 58 , miR-218 83 , miR-138 110 , miR-625 111 , miR-212 112 , miR-124 131 , miR-22 49 , miR-133b 39 , miR-193a-3p 104 , miR-195 113 and miR-30c 103 associated with worse prognosis (lower overall survival) of CRC patients. Fifty-six studies identified the upregulation of miR-181a 31–33 , miR-182 43, 44 , miR-1296 84 , miR-888 64 , miR-28-5p 132 , miR-183 45, 46 , miR-200c 114 , miR-34a 133 , miR-15a-5p 134 , miR-181c 135 , miR-24-3p 53 , miR-16 35 , miR-7 55 , miR-96 86 , miR-1260b 115 , miR-20a-5p 63 , miR-517a 87 , miR-503 136 , miR-106b 88 , miR-211 137 , miR-320e 89 , miR-592 90 , miR-196a 57 , miR-196b 57 , miR-376a …”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Tissue micro-RNAs associated with colorectal cancer prognosis: a systematic review

Santos

Penna

Carneiro

et al. 2019

Preprint

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Colorectal cancer (CRC) is a multifactorial disease commonly diagnosed worldwide, with high mortality rates. Several studies demonstrate important associations between differential expression of micro-RNAs (miRs) and the prognosis of CRC. However, only a few systematic reviews emphasize the most relevant miRs able to contribute to the establishment of new prognostic biomarkers in CRC patients. The present study aimed to identify differentially expressed tissue miRs associated with prognostic factors in CRC patients, through a systematic review of the Literature. Using the PubMed database, Cochrane Library and Web of Science, studies published in English evaluating miRs differentially expressed in tumor tissue and significantly associated with the prognostic aspects of CRC were selected. All the included studies used RT-PCR (Taqman or SYBR Green) for miR expression analysis and the period of publication was from 2009 to 2018. A total of 115 articles accomplished the inclusion criteria and were included in the review. The studies investigated the expression of 102 different miRs associated with prognostic aspects in colorectal cancer patients. The most frequent oncogenic miRs investigated were miR-21, miR-181a, miR-182, miR-183, miR-210 and miR-224 and the hyperexpression of these miRs was associated with distant metastasis, lymph node metastasis and worse survival in patients with CRC. The most frequent tumor suppressor miRs were miR-126, miR-199b and miR-22 and the hypoexpression of these miRs was associated with distant metastasis, worse prognosis and a higher risk of disease relapse (worse disease-free survival). Specific tissue miRs are shown to be promising prognostic biomarkers in patients with CRC, given their strong association with the prognostic aspects of these tumors, however, new studies are necessary to establish the sensibility and specificity of the miRs in order to use them in clinical practice.

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“…The copyright holder for this preprint (which was this version posted November , miR-944 71 , miR-30d 72 , miR-22 50 , miR-296 73 , miR-384 74 , miR-199b , miR-149 79 , miR-194 80 , miR-133b 37 , miR-15a 34 , miR-100 81 , miR-133a 41 , miR-335 82 , miR-378a-3p 58 , miR-378a-5p , miR-7 55 , miR-96 86 , miR-20a-5p 63 , miR-517a , miR-720 91 , miR-133a 42 , miR-630 92 , miR-181a 31 , miR-210 93 , miR-25 94 , miR-191 95 , miR-92a 96 , miR-31 59 , miR-552 97 Tumor Growth miR-302c , let-7a-5p 98 , miR-132 99 , miR-497 107 , miR-206 100 , miR-128 75 , miR-193a-5p 108 , miR-100 81 , miR-133a 41 , miR-625 111 , miR-212 112 , miR-195 113 , miR-133b 37 , miR-30c 103 miR-1296 84 , miR-200c 114 , miR-21 26,29 , miR-130a 85 , miR-7 55 , miR-96 43,44 , miR-25 94 , miR-191…”

Section: Characteristics Of the Selected Studiesmentioning

confidence: 99%