Down-regulation of MRPS23 inhibits LPS-induced proliferation and invasion<i>via</i>regulation of the NF-κB signaling pathway in osteosarcoma cells

Liu, Aiguo; Xu, Kelin; Wang, Weilin; Zhou, Bingkang; Guo, Qinggong

doi:10.1039/c8ra08973f

Cited by 2 publications

(1 citation statement)

References 47 publications

(46 reference statements)

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“…TMB and MSI are a biomarker for cancer immune checkpoint inhibitors [ 16 , 17 ]. It has been reported that MRPS23 could inhibit NF-κB signaling pathway in OS cell [ 18 ]. Our research also indicated MRPS23 expression level is in relation to the stem cell, infiltration of immune cells, m1A, m5C and m6A in human cancer.…”

Section: Discussionmentioning

confidence: 99%

MRPS23 is a novel prognostic biomarker and promotes glioma progression

Wang,

Chen,

Liu

et al. 2024

Aging

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Mitochondrial ribosomal protein S23 (MRPS23), a component of the ribosome small subunit, has been reported to be overexpressed in various cancers and has been predicted to be involved in increased cell proliferation. It has been confirmed that MRPS23 was involved in the regulation of breast cancer and hepatocellular carcinoma cell proliferation. However, little is known about the function of MRPS23 in glioma. In this study, we found that MRPS23 expression was higher in gliomas than in adjacent normal tissues. Higher expression of MRPS23 in gliomas correlated with poorer prognosis, unfavorable histological features, absence of mutations in the isocitrate dehydrogenase gene (IDH), absence of chromosome 1p and 19q deletions, and responses to chemoradiotherapy. Univariate and multivariate Cox analysis demonstrated MRPS23 expression was independently prognostic of overall survival, disease-free survival, and progression-free survival in patients with glioma. KEGG enrichment analysis results indicated that high MRPS23 expression was associated with cell proliferation and immune response-related signaling pathways. We also confirmed that MRPS23 was highly expressed in glioma cells lines, and MRPS23 knockdown significantly reduced cell survival, proliferation, and migration of glioma cells lines. Collectively, these findings offer mechanistic insights into how MRPS23 during glioma progression, and identify MRPS23 as a potential therapeutic target in the future.

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Section: Discussionmentioning

confidence: 99%

MRPS23 is a novel prognostic biomarker and promotes glioma progression

Wang,

Chen,

Liu

et al. 2024

Aging

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How Should Journals Address a Procedure That Turns out to Be Dangerous?

Trashi,

Satish,

Nguyen

et al. 2024

ACS Chem. Health Saf.

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This Commentary critically evaluates scientific journals' responsibility in addressing safety concerns within chemical research publications. We highlight the risks associated with uncritically accepting initial safety claims in the chemical literature, especially when such claims are later retracted or corrected. Our analysis focuses on three specific cases where procedures initially deemed safe necessitated significant safety corrections, and we emphasize the inadequate response of the publishing community to these updates. It is important to note that safety corrections often remain less visible and less cited than the original flawed publications. We scrutinize the mechanisms publishers employ for marking safety-related corrections and retractions and find them inconsistent and insufficiently visible to alert researchers, particularly trainees and those with less experience. We propose more effective strategies to enhance the clarity and prominence of safety information, including mandatory peerreview by chemical safety specialists and prominent watermarking of papers with safety corrections. We also advocate for authors and reviewers to use a safety checklist that includes detailed hazard identification, clear storage and handling instructions, and justification of hazardous reagents. Our Commentary underscores the shared responsibility across the scientific ecosystem in maintaining safety standards, advocating for a proactive role by journal publishers in protecting researchers from hazardous procedures and compounds, thus prioritizing safety in the publication of chemical research.

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Down-regulation of MRPS23 inhibits LPS-induced proliferation and invasionviaregulation of the NF-κB signaling pathway in osteosarcoma cells

Cited by 2 publications

References 47 publications

MRPS23 is a novel prognostic biomarker and promotes glioma progression

MRPS23 is a novel prognostic biomarker and promotes glioma progression

How Should Journals Address a Procedure That Turns out to Be Dangerous?

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