Downregulation of genes related to immune and inflammatory response in IVF implantation failure cases under controlled ovarian stimulation

Pathare, Amruta D S; Zaveri, Kusum; Hinduja, Indira

doi:10.1111/aji.12679

Cited by 44 publications

(47 citation statements)

References 48 publications

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“…LIF was proposed as a biomarker for endometrial receptivity, since it is a pleiotropic cytokine playing multiple roles in endometrium and embryo differentiation. 32 Interestingly, it has been shown that urine-purified and recombinant hCG are able to stimulate the production of LIF both in vitro 33 and human female in vivo. 31 In humans, endometrial expression of LIF was significantly decreased in patients with implantation failure as compared with healthy donors.…”

Section: Effect Of Hcg On Biomarkers Of Endometrial Receptivitymentioning

confidence: 99%

“…31 In humans, endometrial expression of LIF was significantly decreased in patients with implantation failure as compared with healthy donors. 32 Interestingly, it has been shown that urine-purified and recombinant hCG are able to stimulate the production of LIF both in vitro 33 and human female in vivo. 34 Glycodelin is a major secretory protein from the glandular endometrium being expressed during and after the WOI.…”

Section: Effect Of Hcg On Biomarkers Of Endometrial Receptivitymentioning

confidence: 99%

See 1 more Smart Citation

Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF/ET cycle: The critical review

Zhang

Chen

Wang

et al. 2019

American J Rep Immunol

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Intrauterine infusion of human chorionic gonadotropin (IUI‐hCG) has been proposed to improve the outcome of in vitro fertilization‐embryo transfer (IVF‐ET), since it plays a critical role in synchronizing endometrial and fetal development. As the early mediator from embryo, hCG promotes the decidualization, angiogenesis, maternal immune tolerance, and trophoblast invasion, favoring successful implantation of embryo. Although multiple clinical trials have been conducted to verify the efficacy of IUI‐hCG on IVF‐ET outcome in recent years, the findings remained controversial. The difference in study design and population might be the cause to the different consequences after administration of hCG. More importantly, the endometrial receptivity, which might affect the efficacy of IUI‐hCG, has not been assessed in women receiving this intervention. Selecting the right population suitable for IUI‐hCG based on known etiology would be crucial in enhancing its efficacy and minimize any possible complications. Investigation of optimal indications for IUI‐hCG should be highlighted in the future.

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Section: Effect Of Hcg On Biomarkers Of Endometrial Receptivitymentioning

confidence: 99%

Section: Effect Of Hcg On Biomarkers Of Endometrial Receptivitymentioning

confidence: 99%

Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF/ET cycle: The critical review

Zhang

Chen

Wang

et al. 2019

American J Rep Immunol

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“…[6][7][8] Controlled ovarian hyperstimulation reduces VEGF during uterine receptivity, 4 which is regulated by estrogen and selective ER modulators in endometrial stromal cells. [6][7][8] Controlled ovarian hyperstimulation reduces VEGF during uterine receptivity, 4 which is regulated by estrogen and selective ER modulators in endometrial stromal cells.…”

Section: Introductionmentioning

confidence: 99%

“…However, uterine receptivity is deteriorated during COH in animal and clinical study. [6][7][8] Controlled ovarian hyperstimulation reduces VEGF during uterine receptivity, 4 which is regulated by estrogen and selective ER modulators in endometrial stromal cells. 9 It has been suggested that, due to COH, the peak serum estradiol level during the early luteal phase caused a time shift of the implantation window.…”

Section: Introductionmentioning

confidence: 99%

The ameliorating effects of Bushen Tiaoxue Granules and Kunling Wan on impaired angiogenesis and endometrial receptivity in rats following controlled ovarian hyperstimulation

Sun

et al. 2019

Microcirculation

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Objective To investigate the effects of Bushen Tiaoxue Granules and Kunling Wan, the two Chinese medicines, on vascular dysfunction and the impairment of endometrial receptivity caused by controlled ovarian hyperstimulation and its underlying mechanism. Methods Female Sprague Dawley rats with regular estrous cycle were enrolled and given Bushen Tiaoxue Granules or Kunling Wan by gavage for 12 days, and then, controlled ovarian hyperstimulation model was induced. We assessed endometrial microvessels, endometrial blood flow, levels of estradiol and progesterone in serum, vascular endothelial growth factor A upstream molecules estrogen and progesterone receptors in the endometrium, and pregnancy outcome. Results Pre‐treatment of Bushen Tiaoxue Granules or Kunling Wan increases endometrial blood flow of controlled ovarian hyperstimulation rats, up‐regulates vascular endothelial growth factor A and microvessels, improves the endometrial morphology of controlled ovarian hyperstimulation rats during implantation, decreases the super physiological concentration of estradiol and progesterone in serum, and increases the expression of vascular endothelial growth factor A upstream molecules estrogen and progesterone receptors in the endometrium. In addition, Bushen Tiaoxue Granules or Kunling Wan elevates the lysophosphatidic acid receptor 3 that participates in vascularization and increases the expression of leukemia inhibitory factor through up‐regulating the expression of p53 in the endometrium, ultimately affecting pregnancy outcome. Conclusion This study demonstrated Bushen Tiaoxue Granules or Kunling Wan as a potential strategy for prevention of impairment in angiogenesis and endometrial receptivity induced by controlled ovarian hyperstimulation.

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“…Therefore, the key for increasing embryo implantation rate and clinical pregnancy rate is to improve endometrial receptivity. Multiple studies have shown that leukemia inhibitory factor (LIF), insulin-like growth factor-I (IGF-1), and epidermal growth factor (EGF) exhibit high expression levels during the implantation window of several different species of mammals [8,9]. In addition, the concerted effects of these factors contribute to the establishment of endometrial tolerance.…”

Section: Introductionmentioning

confidence: 99%

Impact of Kuntai Capsules on LIF, IGF-1 and EGF Expression in the Implantation Window of Endometrium in Mice

Tan

Chu

et al. 2018

Preprint

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Objective: This study aims to investigate the influence of Kuntai capsules on the expression level of leukemia inhibitory factor (LIF), insulin-like growth factor-I (IGF-1) and epidermal growth factor (EGF) during the mouse's implantation window of superovulation period and controlled ovarian hyperstimulation period. Methods: A total of 90 female mice were randomly divided into six groups (n=15, each group).The RNA expression of EGF, LIF and IGF-1 in the endometrium on the 4 th day of pregnancy was detected using the fluorescence quantitative PCR method, and the relative expression of these three factors in each group was compared. Results: The mRNA expression of these three factors in the endometrium during the mouse's implantation window period was significantly lower in the superovulation group and COH group than in the control group (P<0.001), and was obviously lower in the superovulation group than in the COH group (P<0.05). The mRNA expression of these three factors in the endometrium remained obviously lower in the superovulation plus kuntai capsule group and COH plus kuntai capsule group, compared with the control group (P<0.01). The mRNA expression of these three factors in the endometrium was lower in control group than in the NS plus kuntai capsule group (P<0.05). Furthermore, the expression in the superovulation and COH groups was lower than in the COH plus kuntai capsule group (P<0.05). Conclusions:Both the superovulation and COH procedure could reduce the mouse's endometrial receptivity. The application of the Chinese medicine Kuntai capsule could partially improve a mouse's endometrial receptivity through the increasing expression of three relevant cytokines during the implantation window.

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Downregulation of genes related to immune and inflammatory response in IVF implantation failure cases under controlled ovarian stimulation

Abstract: Importance of immune and inflammatory response in endometrial receptivity adds on to the current knowledge of gene expression profile in IF under COS. The panel of genes involved in these pathways would be useful in determining further line of treatment for IF during IVF.

Cited by 44 publications

References 48 publications

Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF/ET cycle: The critical review

Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF/ET cycle: The critical review

The ameliorating effects of Bushen Tiaoxue Granules and Kunling Wan on impaired angiogenesis and endometrial receptivity in rats following controlled ovarian hyperstimulation

Impact of Kuntai Capsules on LIF, IGF-1 and EGF Expression in the Implantation Window of Endometrium in Mice

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