Downregulation of <i>ATM</i> Gene and Protein Expression in Canine Mammary Tumors

Raposo-Ferreira, T M M; Bueno, R.; Terra, Erika Maria; Avante, Michelle Lopes; Tinucci‐Costa, Mirela; Carvalho, Marcelo; Cassali, Geovanni Dantas; Linde, Sandra; Rogatto, Sílvia Regina; Laufer-Amorim, Renée

doi:10.1177/0300985816643367

Cited by 7 publications

(4 citation statements)

References 45 publications

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“…There is significant overlap between deregulated human and canine genes in mammary tumors, as well as from normal mammary tissues (195). ATM mRNA and protein expression were shown to be downregulated in canine mammary tumors (196), consistent with frequently observed checkpoint and DNA repair defects in human tumors (2,16). Recently the molecular mechanisms of both XLF and Ku-dependent NHEJ in canines was evaluated and proposed as a platform for development of novel chemotherapies for dogs and humans (197,198).…”

Section: Past Present and Future Translational Research Opportunitiesupporting

confidence: 80%

Translational research in radiation-induced DNA damage signaling and repair

Nickoloff¹,

Boss²,

Allen³

et al. 2017

Transl. Cancer Res

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Radiotherapy is an effective tool in the fight against cancer. It is non-invasive and painless, and with advanced tumor imaging and beam control systems, radiation can be delivered to patients safely, generally with minor or no adverse side effects, accounting for its increasing use against a broad range of tumors. Tumors and normal cells respond to radiation-induced DNA damage by activating a complex network of DNA damage signaling and repair pathways that determine cell fate including survival, death, and genome stability. DNA damage response (DDR) proteins represent excellent targets to augment radiotherapy, and many agents that inhibit key response proteins are being combined with radiation and genotoxic chemotherapy in clinical trials. This review focuses on how insights into molecular mechanisms of DDR pathways are translated to small animal preclinical studies, to clinical studies of naturally occurring tumors in companion animals, and finally to human clinical trials. Companion animal studies, under the umbrella of comparative oncology, have played key roles in the development of clinical radiotherapy throughout its >100-year history. There is growing appreciation that rapid translation of basic knowledge of DNA damage and repair systems to improved radiotherapy practice requires a comprehensive approach that embraces the full spectrum of cancer research, with companion animal clinical trials representing a critical bridge between small animal preclinical studies, and human clinical trials.

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Section: Past Present and Future Translational Research Opportunitiesupporting

confidence: 80%

Translational research in radiation-induced DNA damage signaling and repair

Nickoloff¹,

Boss²,

Allen³

et al. 2017

Transl. Cancer Res

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“…There are concomitant arguments for using the dog as a model of aging (also presenting with limitations and differences) ( 131 ). Although similarities between canine and human DNA repair machinery have been shown, such as in lymphoma, mammary tumors and even OSA ( 132 , 155 , 156 ), not every mechanism may be similar, for example base excision repair and nucleotide excision repair have both been shown to be lower in canines ( 157 ). Unfortunately little is known about DNA repair in canine OSA ( 158 ) even though it may play significant roles when comparing geriatric with juvenile/pediatric OSA.…”

Section: Limitations Of Canine Osa Modelsmentioning

confidence: 99%

Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery

Simpson

Rizvanov²,

Jeyapalan³

et al. 2022

Front. Vet. Sci.

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Cancer is a leading cause of non-communicable morbidity and mortality throughout the world, similarly, in dogs, the most frequent cause of mortality is tumors. Some types of cancer, including osteosarcoma (OSA), occur at much higher rates in dogs than people. Dogs therefore not only require treatment themselves but can also act as an effective parallel patient population for the human disease equivalent. It should be noted that although there are many similarities between canine and human OSA, there are also key differences and it is important to research and highlight these features. Despite progress using chorioallantoic membrane models, 2D and 3D in vitro models, and rodent OSA models, many more insights into the molecular and cellular mechanisms, drug development, and treatment are being discovered in a variety of canine OSA patient populations.

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“…Other overlapping clinical characteristics are represented by tumor size development, clinical stage of the neoplasm, and lymph node metastases. Moreover, molecular similarities mainly include overexpression of steroid receptors, same proliferation markers, epidermal growth factor involvement, gene mutations, and expression patterns [ 247 , 248 , 249 , 250 , 251 ]. Significant results have also been obtained in prostate cancer [ 252 , 253 ], bladder cancer [ 237 , 254 , 255 , 256 ], bone cancer, especially osteosarcoma [ 257 , 258 ], and lymphomas [ 259 , 260 ] in terms of species (canines-humans) extrapolation for translational oncology.…”

Section: Spontaneous Large Animal Models For Cancer Researchmentioning

confidence: 99%

Spontaneous and Induced Animal Models for Cancer Research

Onaciu

Munteanu

et al. 2020

Diagnostics

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Considering the complexity of the current framework in oncology, the relevance of animal models in biomedical research is critical in light of the capacity to produce valuable data with clinical translation. The laboratory mouse is the most common animal model used in cancer research due to its high adaptation to different environments, genetic variability, and physiological similarities with humans. Beginning with spontaneous mutations arising in mice colonies that allow for pursuing studies of specific pathological conditions, this area of in vivo research has significantly evolved, now capable of generating humanized mice models encompassing the human immune system in biological correlation with human tumor xenografts. Moreover, the era of genetic engineering, especially of the hijacking CRISPR/Cas9 technique, offers powerful tools in designing and developing various mouse strains. Within this article, we will cover the principal mouse models used in oncology research, beginning with behavioral science of animals vs. humans, and continuing on with genetically engineered mice, microsurgical-induced cancer models, and avatar mouse models for personalized cancer therapy. Moreover, the area of spontaneous large animal models for cancer research will be briefly presented.

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Downregulation of ATM Gene and Protein Expression in Canine Mammary Tumors

Cited by 7 publications

References 45 publications

Translational research in radiation-induced DNA damage signaling and repair

Translational research in radiation-induced DNA damage signaling and repair

Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery

Spontaneous and Induced Animal Models for Cancer Research

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