Downregulation of LINC01140 is associated with adverse features of breast cancer

Li, Deheng; Li, Liangdong; Cao, Yiqun; Chen, Xin

doi:10.3892/ol.2019.11147

Cited by 16 publications

(18 citation statements)

References 31 publications

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“…Marina et al demonstrated that LINC01140 was an important regulator of proliferation and inflammation in human lung fibroblasts [ 42 ]. LINC01140 may be a potential biomarker for the prognosis of patients with breast cancer [ 43 ] and gastric cancer [ 44 ]. However, there has no study show the connection between LINC01140 and LUAD.…”

Section: Discussionmentioning

confidence: 99%

Identification of 4 immune cells and a 5-lncRNA risk signature with prognosis for early-stage lung adenocarcinoma

Ding

et al. 2021

J Transl Med

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Background Lung cancer is the most common cancer and cause of cancer‐related mortality worldwide, increasing evidence indicated that there was a significant correlation between tumors and the long non‐coding RNAs (lncRNAs), as well as tumor immune infiltration, but their role in early lung adenocarcinoma (LUAD) are still unclear. Methods Gene expression data and corresponding clinical data of early-stage LUAD patients were downloaded from GEO and TCGA databases. 24 kinds of tumor-infiltrating immune cells were analyzed by quantity analysis and univariate cox regression analysis, we divided patients into two subgroups using consensus clustering, recognized the differentially expressed genes (DEGs) in the subgroups, then, established lncRNA risk signature by least absolute shrinkage and selection operator (LASSO) regression. Results A total of 718 patients were enrolled in this study, including 246 from GSE31210 dataset, 127 from GSE50081 dataset and 345 from TCGA-LUAD. We identified that Th2 cells, TFH, NK CD56dim cells and Mast cells were prognosis-related(p < 0.05), then established a 5-lncRNA risk signature (risk score = 0.374600616* LINC00857 + 0.173825706* LINC01116 + (− 0.021398903)* DRAIC + (− 0.113658256)* LINC01140 + (− 0.008403702)* XIST), and draw a nomogram showed that the signature had a well prediction accuracy and discrimination. Conclusions We identified 4 immune infiltrating cells related to the prognosis of early-stage LUAD, and established a novel 5 immune-related lncRNA signature for predicting patients’ prognosis.

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Section: Discussionmentioning

confidence: 99%

Identification of 4 immune cells and a 5-lncRNA risk signature with prognosis for early-stage lung adenocarcinoma

Ding

et al. 2021

J Transl Med

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“…However, recent study has reported that LINC01140 appears to be a tumor suppressor. 28 Specifically, LINC01140 is downregulated in breast cancer tissues, and on its overexpression, it ultimately affects the epithelial-mesenchymal transition (EMT) process of cells by adsorbing miR-200b and miR-200c, resulting in an antitumor effect. 28 In addition, another study has found that LINC01140 may inhibit the malignant phenotype of glioma cells by modulating the miR-199a-3p/ZHX1 signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

LINC01140 promotes the progression and tumor immune escape in lung cancer by sponging multiple microRNAs

Xia

Geng

et al. 2021

J Immunother Cancer

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BackgroundLong intergenic non-protein coding RNA 1140 (LINC01140), a long non-coding RNA, is highly expressed in various cancers; however, its biological functions in lung cancer (LC) progression and immune escape are still unclear.MethodsHere, to elucidate LINC01140 function, 79 paired LC and paracancerous tissues were collected. LINC01140 expression levels were determined using fluorescence in situ hybridization and qPCR analysis. Cell counting kit-8 (CCK-8) assay and transwell assays were performed. The interaction between microRNAs (miRNAs) and LINC01140 was confirmed using an RNA immunoprecipitation assay. Cytokine-induced killer (CIK) cell phenotypes were analyzed by flow cytometry. Cytokine secretion levels were determined by ELISA. CIK cytotoxicity was assessed by measuring lactate dehydrogenase release. Besides, xenograft tumor mouse models were used to unveil the in vivo function of LINC01140.ResultsWe found that LINC01140 was highly expressed in human LC tissues and cell lines. High LINC01140 levels were associated with poor survival in patients with LC. LINC01140 upregulation promoted the proliferation, migration, and invasion of LC cells through direct interaction with miR-33a-5p and miR-33b-5p, thereby contributing to c-Myc expression and also inhibited cisplatin-induced cell apoptosis. In subcutaneous tumor xenograft mice, LINC01140 knockdown markedly reduced tumor growth and lung metastasis. Additionally, LINC01140 directly repressed miR-377-3 p and miR-155-5 p expression levels, resulting in the upregulation of their common downstream target programmed death-ligand 1 (PD-L1), a crucial target in LC immunotherapy. Notably, we proved that LINC01140 knockdown, along with CIK administration, suppressed the growth of subcutaneous LC xenografts by decreasing PD-L1 expression in severe combined immunodeficient mice.ConclusionsTaken together, LINC01140 overexpression protects c-Myc and PD-L1 mRNA from miRNA-mediated inhibition and contributes to the proliferation, migration, invasion, and immune escape of LC cells. These results provide a theoretical basis that LINC01140 is a promising target for LC treatment.

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“…Then, significant ternary relationships (DEmiRNA-DEmRNA-DElncRNA) were selected, and the top degrees of lncRNA in these were thought to be the key lncRNAs, and the mRNA interactions with these key lncRNAs were explored in Although lncRNA-associated research is limited, the key lncRNAs obtained above have been found to be related to some other diseases, for example, downregulation of LINC01140 is associated with adverse features of breast cancer, 37 and significantly correlates with overall survival in gastric cancer patients. 38 High MSC-AS1 expression was correlated with poorer prognosis in patients with pancreatic ductal adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…Although lncRNA-associated research is limited, the key lncRNAs obtained above have been found to be related to some other diseases, for example, down-regulation of LINC01140 is associated with adverse features of breast cancer, 37 and significantly correlates with overall survival in gastric cancer patients. 38 High MSC-AS1 expression was correlated with poorer prognosis in patients with pancreatic ductal adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Potential Key IncRNAs with Endometriosis by Construction of a ceRNA Network

Gu¹,

Meng²,

Meng³

et al. 2021

IJGM

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The etiology and pathophysiology of endometriosis remain unclear. Current research indicates long noncoding RNA (lncRNA) may play an important role in the pathogenesis and development of endometriosis. However, the molecular mechanism of lncRNA in endometriosis is far from clear. Patients and Methods: The lncRNA and mRNA expression of 8 patients with ovarian endometriosis were determined by high-throughput RNA sequencing (8 ectopic endometria samples vs 8 eutopic endometria samples), and miRNA expression profiles were obtained from our previous study. Then a lncRNA-associated competing endogenous RNA (ceRNA) network was constructed by combining the regulatory interaction and negative co-expression interaction between the differentially expressed lncRNAs/mRNAs and miRNAs by different rules. Results: The constructed lncRNA-related ceRNA network was composed of two separate networks, network 1 including 14,137 dysregulated lncRNA-mRNA interactions, referring to 242 lncRNAs, 55 miRNAs and 1600 mRNAs, network 2 including 4459 dysregulated lncRNA-mRNA interactions, referring to 111 lncRNAs, 39 miRNAs and 1151 mRNAs. The top six hub lncRNAs (LINC01140, MSC-AS1, HAGLR, CKMT2-AS1, JAKMIP2-AS1, AL365361.1) in the significant ternary relationship of mRNA-miRNA-lncRNA in network 1, and the top six hub lncRNAs (PAX8-AS1, MIR17HC, PART1, HOXA-AS3, PLAC4, LINC00511) in the significant ternary relationship of mRNA-miRNA-lncRNA in network 2 were selected. Functional enrichment analysis of these lncRNA-related mRNAs indicated that the lncRNAs in network 1 mainly take part in positive regulation of phagocytosis, myeloid leukocyte activation, and tissue remodeling, while the lncRNAs in network 2 mainly take part in negative regulation of cell proliferation, blood vessel development and regulation of epithelial cell differentiation, which is consistent with the results obtained from the different rules to construct the networks. Conclusion: lncRNA-related ceRNA network analysis recognized key lncRNAs related to the development of endometriosis.

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Downregulation of LINC01140 is associated with adverse features of breast cancer

Cited by 16 publications

References 31 publications

Identification of 4 immune cells and a 5-lncRNA risk signature with prognosis for early-stage lung adenocarcinoma

Identification of 4 immune cells and a 5-lncRNA risk signature with prognosis for early-stage lung adenocarcinoma

LINC01140 promotes the progression and tumor immune escape in lung cancer by sponging multiple microRNAs

Exploring the Potential Key IncRNAs with Endometriosis by Construction of a ceRNA Network

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