Downregulation of Low-density lipoprotein receptor-related protein 1B (LRP1B) inhibits the progression of hepatocellular carcinoma cells by activating the endoplasmic reticulum stress signaling pathway

Zhen, Zili; Shen, Zan; Sun, Peilong

doi:10.1080/21655979.2022.2060778

Cited by 8 publications

(6 citation statements)

References 52 publications

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“…GPC6 (glypican 6) is involved in the regulation of cell growth and cell division [ 53 , 54 ]. LRP1B , which is a member of the low-density lipoprotein (LDL) receptor family, is involved in numerous cellular processes [ 55 , 56 ]. CTNNA2 , also known as catenin alpha 2, facilitates the binding of actin filaments and is involved in the regulation of neuron migration and the development of neuron projections [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Single-Nucleus RNA-Seq Reveals Spermatogonial Stem Cell Developmental Pattern in Shaziling Pigs

Tang,

Chen,

Yan

et al. 2024

Biomolecules

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Normal testicular development ensures the process of spermatogenesis, which is a complex biological process. The sustained high productivity of spermatogenesis throughout life is predominantly attributable to the constant proliferation and differentiation of spermatogonial stem cells (SSCs). The self-renewal and differentiation processes of SSCs are strictly regulated by the SSC niche. Therefore, understanding the developmental pattern of SSCs is crucial for spermatogenesis. The Shaziling pig is a medium-sized indigenous pig breed originating from central China. It is renowned for its superior meat quality and early male sexual maturity. The spermatogenic ability of the boars is of great economic importance to the pig industry. To investigate testicular development, particularly the pattern of SSC development in Shaziling pigs, we used single-cell transcriptomics to identify gene expression patterns in 82,027 individual cells from nine Shaziling pig testes at three key postnatal developmental stages. We generated an unbiased cell developmental atlas of Shaziling pig testicular tissues. We elucidated the complex processes involved in the development of SSCs within their niche in the Shaziling pig. Specifically, we identified potential marker genes and cellular signaling pathways that regulate SSC self-renewal and maintenance. Additionally, we proposed potential novel marker genes for SSCs that could be used for SSC isolation and sorting in Shaziling pigs. Furthermore, by immunofluorescence staining of testicular tissues of different developmental ages using marker proteins (UCHL1 and KIT), the developmental pattern of the spermatogonia of Shaziling pigs was intensively studied. Our research enhances the comprehension of the development of SSCs and provides a valuable reference for breeding Shaziling pigs.

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Section: Discussionmentioning

confidence: 99%

Single-Nucleus RNA-Seq Reveals Spermatogonial Stem Cell Developmental Pattern in Shaziling Pigs

Tang,

Chen,

Yan

et al. 2024

Biomolecules

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“…[ 36 ] Meanwhile, low-density lipoprotein receptor-related protein 1B (LRP1B) is another member of the LDLR gene family, inducing HCC metastasis and drug resistance of doxorubicin and depressing the PERK-ATF4-CHOP pathway. [ 37 ] Additionally, microRNA-148a (miR-148a) prevents lung colonization of HCC, with real-time quantitative polymerase chain reaction (RT-qPCR) findings indicating that genes related to FA intake were upregulated in miR-148a KO mice. [ 38 ] ATP binding cassette subfamily A member 8, which has been established to regulate cholesterol efflux and HDL levels, is regulated by miR-374b-5p and impedes the metastasis of HCC.…”

Section: Lipid Metabolic Reprogramming In Hccmentioning

confidence: 99%

The switch triggering the invasion process: Lipid metabolism in the metastasis of hepatocellular carcinoma

Zhang,

et al. 2024

Chinese Medical Journal

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In humans, the liver is a central metabolic organ with a complex and unique histological microenvironment. Hepatocellular carcinoma (HCC), which is a highly aggressive disease with a poor prognosis, accounts for most cases of primary liver cancer. As an emerging hallmark of cancers, metabolic reprogramming acts as a runaway mechanism that disrupts homeostasis of the affected organs, including the liver. Specifically, rewiring of the liver metabolic microenvironment, including lipid metabolism, is driven by HCC cells, propelling the phenotypes of HCC cells, including dissemination, invasion, and even metastasis in return. The resulting formation of this vicious loop facilitates various malignant behaviors of HCC further. However, few articles have comprehensively summarized lipid reprogramming in HCC metastasis. Here, we have reviewed the general situation of the liver microenvironment and the physiological lipid metabolism in the liver, and highlighted the effects of different aspects of lipid metabolism on HCC metastasis to explore the underlying mechanisms. In addition, we have recapitulated promising therapeutic strategies targeting lipid metabolism and the effects of lipid metabolic reprogramming on the efficacy of HCC systematical therapy, aiming to offer new perspectives for targeted therapy.

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“…A study by Li et al [21] showed that high expression of LRP1B can mediate lipid metabolism of hepatocellular carcinoma cells. Zhen et al [22] discovered that LRP1B plays an imperative role in promoting hepatocellular carcinoma progression by regulating the PERK-ATF4-CHOP signalling pathway. However, there are few studies on LRP1B in TC, and further research should be carried out.…”

Section: Western Blotmentioning

confidence: 99%

MicroRNA-196a-5p targeting LRP1B modulates phenotype of thyroid carcinoma cells

Zhang

Chang

et al. 2023

Endokrynol Pol

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circRNA_0000140 on the growth and metastasis of oral squamous cell carcinoma [11]. MicroRNA-146b-5p hampers metastasis and tumourigenesis of gallbladder cancer by targeting Toll-like receptor 4 via the nuclear factor-κB pathway [12]. MicroRNA-133b can suppress colorectal cancer metastasis by lncRNA LUCAT1 [13]. MicroR-NA-196a-5p is a conserved microRNA derived from its precursor . MicroRNA-196a-5p has been studied in diseases including non-small cell lung cancer [15], cataracts [16], and gastric cancer [17]. However, in TC, the effect and specific mechanism of microR-NA-196a-5p remain unclear.Low-density lipoprotein receptor-associated protein 1 (LRP1) is a multifunctional receptor involved in many biological processes, including signal transduction, lipoprotein metabolism, regulation of vascular permeability and tension, cell growth, migration, and apoptosis [18]. LRP1B is a tumour suppressor that encodes LDL receptor [19]. LRP1B was originally discovered based on a homozygous deletion analysis in human lung cancer cell lines [20]. LRP1B is a member

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Downregulation of Low-density lipoprotein receptor-related protein 1B (LRP1B) inhibits the progression of hepatocellular carcinoma cells by activating the endoplasmic reticulum stress signaling pathway

Cited by 8 publications

References 52 publications

Single-Nucleus RNA-Seq Reveals Spermatogonial Stem Cell Developmental Pattern in Shaziling Pigs

Single-Nucleus RNA-Seq Reveals Spermatogonial Stem Cell Developmental Pattern in Shaziling Pigs

The switch triggering the invasion process: Lipid metabolism in the metastasis of hepatocellular carcinoma

MicroRNA-196a-5p targeting LRP1B modulates phenotype of thyroid carcinoma cells

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