Downregulation of miR-125a-5p and miR-218-5p in Peripheral Blood Mononuclear Cells of Patients with Relapsing-Remitting Multiple Sclerosis

Aghdam, Arash Mosarrezaii; Rezaei, Somaye; Nalivan, Fariba Zarza; Babaie, Farhad; Nikpour, M.; Torkamandi, Shahram

doi:10.1080/08820139.2021.1909616

Cited by 2 publications

(4 citation statements)

References 49 publications

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“…In the subacute treatment setting, miR-218-5p was significantly upregulated at the end point, which is in agreement with decreased dopaminergic neuron loss in Parkinson’s disease patients due to miR-218-5p targeting LASP1 [ 56 ]. In contrast, downregulation of miR-218-5p has been associated with increased inflammatory response in patients with multiple sclerosis [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

“…There, a neuronal cell model for acute ischemic stroke was used to reduce inflammatory cytokine secretion, oxidative stress, cell apoptosis and maintenance of endovascular homeostasis via upregulating NDRG4. Several diagnostic miRNA markers for spinal cord injury have already been described in the literature [ 57 , 61 , 68 , 93 , 94 , 95 , 96 ]. In our study, we found miR-218-5p, miR-199a-3p, miR-29c-3p, miR-133b to be similarly up- or downregulated following spinal cord injury.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Extracorporeal Shockwave Therapy on Functional Recovery and Circulating miR-375 and miR-382-5p after Subacute and Chronic Spinal Cord Contusion Injury in Rats

et al. 2022

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Extracorporeal shockwave therapy (ESWT) can stimulate processes to promote regeneration, including cell proliferation and modulation of inflammation. Specific miRNA expression panels have been established to define correlations with regulatory targets within these pathways. This study aims to investigate the influence of low-energy ESWT—applied within the subacute and chronic phase of SCI (spinal cord injury) on recovery in a rat spinal cord contusion model. Outcomes were evaluated by gait analysis, µCT and histological analysis of spinal cords. A panel of serum-derived miRNAs after SCI and after ESWT was investigated to identify injury-, regeneration- and treatment-associated expression patterns. Rats receiving ESWT showed significant improvement in motor function in both a subacute and a chronic experimental setting. This effect was not reflected in changes in morphology, µCT-parameters or histological markers after ESWT. Expression analysis of various miRNAs, however, revealed changes after SCI and ESWT, with increased miR-375, indicating a neuroprotective effect, and decreased miR-382-5p potentially improving neuroplasticity via its regulatory involvement with BDNF. We were able to demonstrate a functional improvement of ESWT-treated animals after SCI in a subacute and chronic setting. Furthermore, the identification of miR-375 and miR-382-5p could potentially provide new targets for therapeutic intervention in future studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of Extracorporeal Shockwave Therapy on Functional Recovery and Circulating miR-375 and miR-382-5p after Subacute and Chronic Spinal Cord Contusion Injury in Rats

et al. 2022

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“…Mosarrezaii Aghdam et al reported an association of miR‐125a‐5p and miR‐218‐5p with disease pathogenesis. 26 Myasthenia gravis (MG) is a neuromuscular disease that results in skeletal muscle weakness. Although the determination of serum antibodies of acetylcholine receptor (AChR+) or muscle‐specific tyrosine kinase (MuSK+) is often insufficient to reflect disease progression, the development of a reliable biomarker panel would help to understand disease progression.…”

Section: Mirna and Disease Associationmentioning

confidence: 99%

“…Numerous studies have confirmed that miRNAs are valuable pathological and diagnostic prognostic markers. Mosarrezaii Aghdam et al reported an association of miR‐125a‐5p and miR‐218‐5p with disease pathogenesis 26 . Myasthenia gravis (MG) is a neuromuscular disease that results in skeletal muscle weakness.…”

Section: Mirna and Disease Associationmentioning

confidence: 99%

Dynamic interplay of microRNA in diseases and therapeutic

2022

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MicroRNAs are the major class of small non‐coding RNAs, evolutionary conserved post‐transcriptional regulators of gene expression. Since their discovery in 1993, they have been implicated as master regulators in numerous cellular processes. MicroRNA (miRNA)s regulate gene expression by attenuation and/or mRNA degradation and are commonly associated with cell development, differentiation, and homeostasis. Extensive research in past two decades has provided new insights into the potential implications of miRNA in the onset, progression, and therapeutic nature of miRNAs in disease manifestation. Owing to the novel discoveries, “miRNAs” would probably pave a new direction in therapeutic research. However, “micro” in length miRNAs have attracted considerable attention in numerous other fields. Understanding the functionality of miRNAs, in this review article, we discussed the mechanistic role of miRNAs in human diseases and have outlined most of the recent published work in clinical therapeutics. We have constructed different network models for miRNA and its targets which made us understand their interrelationship and association with diseases. Future research would surely overcome challenges and would introduce new strategies for the utility of miRNAs in a broader setting.

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Downregulation of miR-125a-5p and miR-218-5p in Peripheral Blood Mononuclear Cells of Patients with Relapsing-Remitting Multiple Sclerosis

Cited by 2 publications

References 49 publications

Effects of Extracorporeal Shockwave Therapy on Functional Recovery and Circulating miR-375 and miR-382-5p after Subacute and Chronic Spinal Cord Contusion Injury in Rats

Effects of Extracorporeal Shockwave Therapy on Functional Recovery and Circulating miR-375 and miR-382-5p after Subacute and Chronic Spinal Cord Contusion Injury in Rats

Dynamic interplay of microRNA in diseases and therapeutic

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