Downregulation of miR-362-5p inhibits proliferation, migration and invasion of human breast cancer MCF7 cells

Ni, Fang; Gui, Zhaohua; Guo, Qiang; Hu, Zhongqian; Wang, Xinyi; Chen, Danlei; Wang, Siying

doi:10.3892/ol.2015.3993

Cited by 35 publications

(36 citation statements)

References 27 publications

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“…miR‐130b is overexpressed in metastatic renal cell carcinomas and is a member of a 4‐miRNA signature that is predictive of the risk of tumour metastasis . Inhibition of hsa‐miR‐362‐5p (cfa‐miR‐362 homologue) has been shown to decrease the proliferation, migration and invasion of MCF7 breast cancer cells, and the growth and metastasis of hepatocellular carcinoma cells in vivo . Conversely, down‐regulation of hsa‐miR‐124‐3p (homologue of cfa‐miR‐124) in numerous cancers and hsa‐miR‐548c‐3p (mml‐miR‐548c homologue) in breast cancer implies a metastasis suppressor role.…”

Section: Discussionmentioning

confidence: 99%

Metastasis‐associated microRNA expression in canine uveal melanoma

Starkey

Compston‐Garnett

Malho

et al. 2017

Vet Comparative Oncology

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Section: Discussionmentioning

confidence: 99%

Metastasis‐associated microRNA expression in canine uveal melanoma

Starkey

Compston‐Garnett

Malho

et al. 2017

Vet Comparative Oncology

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“…In breast cancer, a number of miRNAs have been reported to affect growth and metastasis. For example, miR-362-5p may target CYLD lysine 63 deubiquitinase to inhibit the proliferation, migration and invasion of breast cancer cells (26). Zhang et al (27) reported that miR-147 repressed the growth and metastasis of breast cancer through the Akt/mechanistic target of rapamycin pathway.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑154/ADAM9 axis inhibits the proliferation, migration and invasion of breast cancer cells

et al. 2017

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Abstract. Breast cancer is the leading cause for cancer-associated mortality in women. Although great progress has been made in the earlier diagnosis and systemic therapy of patients with breast cancer in recent years, recurrence or distant metastasis continue to present major barriers to the successful treatment of breast cancer. Therefore, fully understanding the molecular mechanisms underlying the progression of breast cancer may be critical for the development of effective therapeutic strategies against breast cancer. The aim of the present study was to explore the expression, function and molecular mechanisms of microRNA-154 (miR-154) in human breast cancer. It was demonstrated that miR-154 was significantly downregulated in breast cancer tissue and cell lines. The restoration of miR-154 expression suppressed the proliferation, migration and invasion of breast cancer cells. ADAM metallopeptidase domain 9 (ADAM9) was identified as a novel direct target for miR-154 in breast cancer. It was demonstrated that miR-154 acted as a tumor suppressor in breast cancer by targeting ADAM9. The results of the present study suggest that the restoration of miR-154 expression may be an effective therapeutic strategy for the treatment of breast cancer in the future.

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“…MiR‐362‐5p inhibits (Ni et al, ; Zou et al, ) or promotes (Ni et al, ) a variety of cancers. Recently, its overexpression has been shown to contribute to HCC malignancy (Shen et al, ).…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA CASC2 regulates hepatocellular carcinoma cell oncogenesis through miR‐362‐5p/Nf‐κB axis

Zhao

Zhang

2018

Journal Cellular Physiology

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The long non-coding RNA segment cancer susceptibility candidate 2 (CASC2) has been shown to suppress tumor growth in a variety of cancers, including hepatocellular carcinoma (HCC). However, the mechanism by which CASC2 exerts control over HCC has yet to be established. In the present study, we first demonstrated that CASC2 is downregulated in human HCC tissues and HCC cell lines as compared to adjacent non-tumor tissues (NTTs) and a liver cell line, respectively. After finding that CASC2 knockdown significantly promotes HCC cells migration and invasion as well as that CASC2 overexpression inhibits cell migration and invasion, we identified the microRNA miR-362-5p as an endogenous target of CASC2. Through the use of wild type and mutant CASC2 binding sites inserted into psiCHECK-2 luciferase reporter plasmids, as well as qRT-PCR, we determined that CASC2 overexpression reduces miR-362-5p expression levels, while inhibiting CASC2 activity increases miR-362-5p expression. Past research has shown that miR-362-5p stimulates the NF-κB pathway, which has been implicated in the survival and proliferation of a variety of cancer cells. We therefore investigated the effects of CASC2 expression on NF-κB pathway activity. Ultimately, we determined that CASC2 regulates HCC cell activity by targeting miR-362-5p and thus inhibiting the NF-κB pathway. The present study not only identifies CASC2 as an important HCC cell regulator, but also suggests its mechanism of action. It therefore provides the basis for designing strategies to target CASC2 activity and thereby inhibit HCC growth and progression.

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Downregulation of miR-362-5p inhibits proliferation, migration and invasion of human breast cancer MCF7 cells

Cited by 35 publications

References 27 publications

Metastasis‐associated microRNA expression in canine uveal melanoma

Metastasis‐associated microRNA expression in canine uveal melanoma

MicroRNA‑154/ADAM9 axis inhibits the proliferation, migration and invasion of breast cancer cells

Long noncoding RNA CASC2 regulates hepatocellular carcinoma cell oncogenesis through miR‐362‐5p/Nf‐κB axis

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