Downregulation of MST4 Underlies a Novel Inhibitory Role of MicroRNA Let-7a in the Progression of Retinoblastoma

Abstract

of MST4 underlies a novel inhibitory role of microRNA let-7a in the progression of retinoblastoma. Invest

Deciphering potential vascularization factors of on-chip co-cultured hiPSC-derived cerebral organoids

“…Similarly, some factors showed upregulation at day 31 during the peak of pro-angiogenic activity, with decreased expression by day 35. These included lamin A 42 (LMNA; ↑d31), L-lactate dehydrogenase A chain [43][44][45] (LDHA; ↑d31), and serine/ threonine protein kinase 26 46 (STK26 or MST4; ↑d31) (Text Data S2 †).…”

Tandem mass tag (TMT) quantitative protein analysis‐based proteomics and parallel reaction monitoring (PRM) validation revealed that MST4 accelerates osteosarcoma proliferation by increasing MRC2 activity

“…10 Additionally, let-7a inhibits angiogenesis in retinoblastoma (RB) by silencing MST4 and inhibiting the MAPK signaling pathway. 11 An et al showed that MST4, via a nonclassical branch of the Hippo pathway, limits the activation of the stress-induced transcriptional coactivator YAP during gastric tumorigenesis. 12 However, the role of MST4 in OS is unclear, which prompted us to explore the role of MST4 in OS proliferation and to provide a theoretical basis for finding new breakthroughs in the treatment of OS.…”

“…In prostate cancer, overexpression of MST4 can promote the proliferation of cancer cells in vitro and increase tumorigenicity in vivo, facilitating the growth of prostate cancer 10 . Additionally, let‐7a inhibits angiogenesis in retinoblastoma (RB) by silencing MST4 and inhibiting the MAPK signaling pathway 11 . An et al showed that MST4, via a nonclassical branch of the Hippo pathway, limits the activation of the stress‐induced transcriptional coactivator YAP during gastric tumorigenesis 12 .…”

“…*p < 0.05; **p < 0.01; ***p < 0.001. siRNA, small interfering RNA; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling.reduces Thr83 phosphorylation and YAP hyperactivation, proving that this dysregulation of the MST4-YAP axis promotes gastric tumorigenesis and predicts poor clinical outcomes in gastric cancer patients 12. In contrast, let-7a inhibits angiogenesis in RB by silencing MST4 and inhibiting the MAPK signaling pathway 11. However, the role of MST4 in OS remains unclear.…”