Downregulation of TLR4-NF-κB-p38 MAPK Signalling in Cholestatic Rats Treated with Cranberry Extract

Fayed, Aysam M.; Abdalla, Esraa A.; Hassan, Soha A.; Hussein, Mohammed A.; Roshdy, Tamer

doi:10.3923/pjbs.2022.112.122

Cited by 6 publications

(6 citation statements)

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“…Natural anti-oxidants acquired from many alternative medical systems have been shown in multiple studies to exhibit a wide range of biological activity (Abdel-Gawad et al, 2003;Hussein, 2012). Several antioxidant-rich substitutes have been utilised to decrease oxidative stress in animal models (Fayed et al, 2022).…”

Section: Advances Inmentioning

confidence: 99%

“…There are no publications on the antioxidant properties of cranberry extract in the prevention of HFD-induced obesity in rats. As part of our ongoing interest in the pharmacological and medical value of natural products (Abdel Maksoud et al, 2019;Fayed et al, 2022;Borik and Hussein, 2022), This study was created to assess the anti-diabetic and antioxidant effects of cranberry extract against obesity caused by the HFD.in rats.…”

Section: Advances Inmentioning

confidence: 99%

“…Table 2 explains the nutritional components of the regular diet and high-fat diet (Assinewe et al, 2003). (Fayed et al, 2022).…”

Section: Animalsmentioning

confidence: 99%

“…HFD+ Cranberry extract (150 mg / kgbw) Rats were given a highfat diet and receiving one dosage of cranberry extract orally every day (Fayed et al, 2022).…”

mentioning

confidence: 99%

“…HFD plus metformin (500 mg/kgbw) During an 8-week timeframe, rats were fed a HFD with one dose metformin orally (Fayed et al, 2022).…”

mentioning

confidence: 99%

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Cranberry Extract; as a Promising Functional Food to Regulate SREBP1/PPAR–α/CPT-1/ACO Signaling Pathways in HFD-Induced Obesity in Rats

Fayed¹,

Ibrahem²,

Hassan³

et al. 2022

AAVS

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The correlation between obesity and metabolic disorders like Type 2 diabetes, cardiovascular disease, and several types of cancer has made obesity a challenge for world health. The current study's objective was to assess the antioxidant capacity of cranberry extract in high-fat diet-induced obesity. For eight weeks, 36 white albino rats weighing 197±10 g were selected at random to five groups: Group I was administered a regular diet; Group II was fed a high-fat diet; Group III was given a high-fat diet plus cranberry extract (75 mg/kg); Group IV was fed a highfat diet with cranberry extract (150 mg/kg); and Group V was fed a high-fat diet plus metformin (500 mg/kg). The lipid profile was determined using blood samples, and liver tissue samples were used to determine glucose, insulin, leptin, TC, TG, HDL-C, ALT, AST, MDA, TNF-α, PCO. The HFD administrated rats resulted in increased total body weight, glucose, insulin, leptin, cholesterol, triglycerides, MDA, ALT, AST, TNFα and PCO levels, as well as SREBP1 gene expression, according to the findings. However, our findings revealed a significant reduction in HDL-C, GSH, CAT and PON 1 enzyme levels, the expression of the PPARα, CPT I and ACO gene in HFD treated rats. Also, administration of cranberry extract and metformin significantly normalized body weight, blood glucose, insulin, leptin, total cholesterol, triglycerides, HDL-C, TBARS, GSH, CAT, ALT, AST, TNF-and PCO and PON 1 as well as SREBP1, PPARα, CPT I and ACO levels. The biochemical and PCR results are supported by electrophoretic patterns and histological evidence. Conclusions: The findings imply that cranberry extract could be used as a new pharmaceutical drug in the treatment of obesity.

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Section: Advances Inmentioning

confidence: 99%

Section: Advances Inmentioning

confidence: 99%

“…Table 2 explains the nutritional components of the regular diet and high-fat diet (Assinewe et al, 2003). (Fayed et al, 2022).…”

Section: Animalsmentioning

confidence: 99%

“…HFD+ Cranberry extract (150 mg / kgbw) Rats were given a highfat diet and receiving one dosage of cranberry extract orally every day (Fayed et al, 2022).…”

mentioning

confidence: 99%

“…HFD plus metformin (500 mg/kgbw) During an 8-week timeframe, rats were fed a HFD with one dose metformin orally (Fayed et al, 2022).…”

mentioning

confidence: 99%

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