2022
DOI: 10.3389/fonc.2022.906281
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Downregulation of ZNF280A inhibits proliferation and tumorigenicity of colorectal cancer cells by promoting the ubiquitination and degradation of RPS14

Abstract: Colorectal cancer (CRC), one of the cancers with highest mortality, involves complicated molecular mechanisms leading to the onset of malignant phenotypes. ZNF280A, a member of the zinc-finger protein family, was shown to be a promotor of oncogenesis in CRC in this study. ZNF280A was remarkably upregulated in CRC tissues, which was meaningfully associated with tumor progression and poor prognosis in patients with CRC. Loss-of-function studies revealed that ZNF280A knockdown inhibited the development and progre… Show more

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Cited by 7 publications
(1 citation statement)
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“…The combination of bioinformatic analysis and biological experimental results is the trend of researches in the last several years. We have found a cancer-promoting axis in CRC through this way [ 41 ]. Rational application of bioinformatics analysis can help us to screen more promising research directions.…”
Section: Discussionmentioning
confidence: 99%
“…The combination of bioinformatic analysis and biological experimental results is the trend of researches in the last several years. We have found a cancer-promoting axis in CRC through this way [ 41 ]. Rational application of bioinformatics analysis can help us to screen more promising research directions.…”
Section: Discussionmentioning
confidence: 99%