Doxofylline–acrylic acid (1/1)

Abstract

Key indicators: single-crystal X-ray study; T = 273 K; mean (C-C) = 0.004 Å; disorder in main residue; R factor = 0.069; wR factor = 0.169; data-to-parameter ratio = 12.2.The title compound, C 11 H 14 N 4 O 4 ÁC 3 H 4 O 2 , a 1:1 doxofyllineacrylic acid complex, forms via O-HÁ Á ÁN and C-HÁ Á ÁO hydrogen bonds in the solid state. Dimers of (I) aggregate via methyl-acid C-HÁ Á ÁO interactions about inversion centres, and the three-dimensional structure arises fromstacking interactions of the purine molecules.

7-(1,3-Dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6(1H,3H)-dione trichloroacetic acid solvate

“…1). The geometric features of the purine ring system are similar to those in doxophylline (Chen et al, 2006;Feng et al, 2007).…”

“…Comment Doxophylline, 2-(7′-theophyllinemethyl)1,3-dioxolane, is a theophylline derivative which shows interesting bronchodilating activity (Franzone et al, 1981;Villani et al, 1997). Previously, we have reported some compounds containing doxophylline (Chen et al, 2006;Feng et al, 2007).…”

“…For related literature, see: Chen et al (2006; Feng et al (2007); Franzone et al (1981); Li et al (1995); Villani et al (1997).…”