Doxorubicin conjugated carbon dots as a drug delivery system for human breast cancer therapy

Kong, Tingting; Hao, Liang; Wei, Yuanyuan; Cai, Xiaoxiao; Zhu, Bofeng

doi:10.1111/cpr.12488

Cited by 135 publications

(77 citation statements)

References 28 publications

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“… Citric acid and polyene polyamine (PEPA) Oxaliplatin Hepatic cancer cells [ 122 ] 10. Citric acid and ethylenediamine – DOX L929, MCF-7 and CCK-8 [ 117 ] 11. Citric acid and diethylenetriamine PEG-(PAH/DMM) Cisplatin A2780 [ 11 ] 12.…”

Section: Applications Of Cdsmentioning

confidence: 99%

“…Recently Kong et al fabricated a citric acid and ethylenediamine based CDs for drug delivery systems. According to their results they observed that DOX could be quickly loaded on CDs through electrostatic interaction and the CDs/DOX complexes showed better cellular uptake and antitumor efficiency on the breast cancer MCF-7 cells compared with free DOX [ 117 ]. Similarly, some other researchers have also used CDs loaded with DOX for simultaneous cell imaging and drug delivery systems [ 27 , 114 , 118 – 120 ].…”

Section: Applications Of Cdsmentioning

confidence: 99%

See 1 more Smart Citation

Small molecules derived carbon dots: synthesis and applications in sensing, catalysis, imaging, and biomedicine

2019

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Carbon dots (CDs) are the new fellow of carbon family having a size less than 10 nm and attracted much attention of researchers since the last decade because of their unique characteristics, such as inexpensive and facile synthesis methods, easy surface modification, excellent photoluminescence, outstanding water solubility, and low toxicity. Due to these unique characteristics, CDs have been extensively applied in different kind of scientific disciplines. For example in the photocatalytic reactions, drug-gene delivery system, in vitro and in vivo bioimaging, chemical and biological sensing as well as photodynamic and photothermal therapies. Mainly two types of methods are available in the literature to synthesize CDs: the top-down approach, which refers to breaking down a more massive carbon structure into nanoscale particles; the bottom-up approach, which refers to the synthesis of CDs from smaller carbon units (small organic molecules). Many review articles are available in the literature regarding the synthesis and applications of CDs. However, there is no such review article describing the synthesis and complete application of CDs derived from small organic molecules together. In this review, we have summarized the progress of research on CDs regarding its synthesis from small organic molecules (bottom-up approach) via hydrothermal/solvothermal treatment, microwave irradiation, ultrasonic treatment, and thermal decomposition techniques as well as applications in the field of bioimaging, drug/gene delivery system, fluorescence-based sensing, photocatalytic reactions, photo-dynamic therapy (PDT) and photo-thermal (PTT) therapy based on the available literature. Finally, the challenges and future direction of CDs are discussed.

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Section: Applications Of Cdsmentioning

confidence: 99%

Section: Applications Of Cdsmentioning

confidence: 99%

Small molecules derived carbon dots: synthesis and applications in sensing, catalysis, imaging, and biomedicine

2019

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“…DOX can also directly loaded on the surface of CDs for localized cancer therapy by simply mixing these CDs and DOX [127,128]. DOX can be released in the tumor acid microenvironment [129,130]. Chemotherapeutic DNA-modifying cisplatin and topoisomerase II-inhibiting DOX were conjugated on the full-color emissive CDs via a pH sensitive hydrazone bond [131].…”

Section: Fluorescent Cds Conjugated With Chemical Therapeutic Agentsmentioning

confidence: 99%

Recent advance of carbon dots in bio-related applications

Wang

Bao

et al. 2020

J. Phys. Mater.

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Carbon dots (CDs) is a kind of carbon nanoparticles with a plentiful of surface functional groups and tunable emission with different excitation wavelength. Broadly speaking, CDs include carbon nanodots, carbon quantum dots, graphene quantum dots, carbonized polymer dots. Due to the unique nature, they are explored for various applications in the bio-related fields such as bioimaging, sensor for ion and (bio)molecules, catalyst, LED and other fields. They are viewed as great alternative tracers to the current fluorescent biomarkers in personalized nanomedicine and surgery operation monitoring. In this review, we summarized the recent progress in the development of CDs, including improvement in fluorescence properties, two-photon fluorescence, and integration with other modalities as theragnostic agents. Specifically, we discussed the preparation of dual-modal imaging agents to improve the accuracy of diagnosis, the combination of imaging and targeting functionality for the effective accumulation of biomarkers, and the integration of imaging and therapeutic agents to effectively monitor the localization and concentration of therapeutic agents. Finally, the theragnostic agents composed of three functionalities (e.g. targeting, imaging, and therapy) were summarized to provide readers with future perspectives in this field.

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“…On the other hand, though a few articles have investigated both biodistribution and tumor targeting ability, the nanocarrier biodegradation capacity has not been thoroughly investigated. Prior to any clinical trial, the fate of any nanocarrier and its eventual persistence in the body must be addressed . Having conjugated fMLP to the surface of GO, the next objective of our work was to assess the biodegradation capacity of GOfMLP.…”

Section: Resultsmentioning

confidence: 99%

“…In particular, the design of site‐directed (targeted) drug delivery systems that can concentrate a higher amount of drug in the tumor area, inducing less side effects for healthy tissues, is at the forefront of research. Among targeted release systems, platforms with nanosized dimensions have exhibited great potential in biomedical applications . More specifically, graphene‐based materials (GBMs) have been extensively studied in this context …”

Section: Introductionmentioning

confidence: 99%

A Biodegradable Multifunctional Graphene Oxide Platform for Targeted Cancer Therapy

Martín

Ruiz

Keshavan

et al. 2019

Adv Funct Materials

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The design of multifunctional materials able to both selectively deliver a drug into cells in a targeted manner and display an enhanced propensity for biodegradation is an important goal. Here, graphene oxide (GO) is functionalized with the chemotactic peptide N-formyl-methionyl-leucylphenylalanine (fMLP) known to interact with the formyl peptide receptor, which is expressed in different cancer cells, including cervical carcinoma cells. This study highlights the ability of GOfMLP for targeted drug delivery and cancer cell killing and the subsequent degradation capacity of the hybrid. Biodegradation is assessed via Raman spectroscopy and transmission electron microscopy. The results show that GOfMLP is susceptible to faster myeloperoxidase-mediated degradation. The hybrid material, but not GO, is capable of inducing neutrophil degranulation with subsequent degradation, being the first study showing inducible neutrophil degradation by the nanomaterial itself with no prior activation of the cells. In addition, confocal imaging and flow cytometry using HeLa cells demonstrate that GOfMLP is able to deliver the chemotherapeutic agent doxorubicin faster into cells, inducing higher levels of apoptosis, when compared to nonfunctionalized GO. The results reveal that GOfMLP is a promising carrier able to efficiently deliver anticancer drugs, being endowed with the ability to induce its own biodegradation.

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Doxorubicin conjugated carbon dots as a drug delivery system for human breast cancer therapy

Abstract: The results of this study indicated that the CDs-DOX drug delivery system had a potential value in cancer chemotherapeutic application.

Cited by 135 publications

References 28 publications

Small molecules derived carbon dots: synthesis and applications in sensing, catalysis, imaging, and biomedicine

Small molecules derived carbon dots: synthesis and applications in sensing, catalysis, imaging, and biomedicine

Recent advance of carbon dots in bio-related applications

A Biodegradable Multifunctional Graphene Oxide Platform for Targeted Cancer Therapy

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