Doxorubicin eluting microporous polysaccharide scaffolds: An implantable device to expunge tumour

Preethi, G. U.; Sreekutty, J; Unnikrishnan, B.S.; Archana, M.G.; Syama, H.P.; Deepa, M K; Shiji, R.; Anusree, KS; Sreelekha, T.T.

doi:10.1016/j.msec.2019.110332

Cited by 12 publications

(21 citation statements)

References 45 publications

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“…The encouraging observation from the in vitro cytotoxicity studies in 2-D and 3-D culture models urged us to investigate the in vivo antitumor potential of DOX@CM-PIONPs. Dalton Lymphoma Ascites (DLA) tumor model is an established syngeneic tumor model 20 . Here we had used a lower concentration of nanoparticles (equivalent dose of 2.5 mg/kg DOX) to avoid non-specific bio-distribution and systemic toxicity.…”

Section: Resultsmentioning

confidence: 99%

“…Recent progress in 3D cell culture models enabled researchers to replicate the tumor microarchitecture composed of cancer foci within a reactive stroma, which is populated by non-cancer cells such as fibroblasts and endothelial cells in supporting tumor growth and potential drug response 19 , 20 . Due to the excessive expenditure in the development and the generation of drug delivery systems along with undesired side effects and long-term health risks, nanoformulation for the treatment of malignant tumors has the lowermost grant in the drug development scenario.…”

Section: Introductionmentioning

confidence: 99%

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A comprehensive study on 2D, 3D and solid tumor environment to explore a multifunctional biogenic nanoconjugate

Unnikrishnan

Preethi

Sreelekha

2021

Sci Rep

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Emergence of nanotechnology created a drastic change in the field of cancer therapy due to their unique features in drug delivery and imaging. Polysaccharide based nanoparticles have received extensive attention in recent years as promising nanoparticle mediated drug delivery systems. Polysaccharides are endorsed with versatile merits including high drug encapsulation efficiency, efficient drug protection against chemical or enzymatic degradation, unique ability to create a controlled release and cellular internalization. In the current study, we have fabricated doxorubicin-loaded carboxymethylated PST001 coated iron oxide nanoparticles (DOX@CM-PST-IONPs) for better management of cancer. CM-PST coated iron oxide nanoparticles co-encapsulated with chemotherapeutic drug doxorubicin, can be utilized for targeted drug delivery. Biocompatible and non-toxic nanoconjugates was found to be effective in both 2-D and 3-D cell culture system with efficient cancer cell internalization. The bench-marked potential of CM-PIONPs to produce reactive oxygen species makes it a noticeable drug delivery system to compact neoplasia. These nanoconjugates can lay concrete on a better way for the elimination of cancer spheroids and tumor burden.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A comprehensive study on 2D, 3D and solid tumor environment to explore a multifunctional biogenic nanoconjugate

Unnikrishnan

Preethi

Sreelekha

2021

Sci Rep

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“…Preethi et al reported a galactoxyloglucanbased porous hydrogel scaffold with a high porosity of 90% by crosslinking and freeze drying, and chemotherapeutic drug DOX was loaded in the scaffold. [27] The DOX-loaded scaffolds exhibited higher DOX release rate in weakly acidic solution similar to tumor microenvironment (TME) than normal physiological microenvironment, thus preventing systemic toxicity. [27] Furthermore, in vivo tumor therapy studies showed that 77% of tumor size was reduced within 2 days and gradually reduced up to 96% after the implantation.…”

Section: Biomaterials Scaffolds With Local Drug Delivery For Tumor Thementioning

confidence: 99%

“…[27] Furthermore, in vivo tumor therapy studies showed that 77% of tumor size was reduced within 2 days and gradually reduced up to 96% after the implantation. [27] All these results revealed that the DOXloaded hydrogel scaffolds have great potential for combining chemotherapy and bone regeneration. Similarly, Bischoff et al developed a cyclodextrin-coated HA scaffold containing DOX.…”

Section: Biomaterials Scaffolds With Local Drug Delivery For Tumor Thementioning

confidence: 99%

“…[ 27 ] The DOX‐loaded scaffolds exhibited higher DOX release rate in weakly acidic solution similar to tumor microenvironment (TME) than normal physiological microenvironment, thus preventing systemic toxicity. [ 27 ] Furthermore, in vivo tumor therapy studies showed that 77% of tumor size was reduced within 2 days and gradually reduced up to 96% after the implantation. [ 27 ] All these results revealed that the DOX‐loaded hydrogel scaffolds have great potential for combining chemotherapy and bone regeneration.…”

Section: Biomaterials Scaffolds With Local Drug Delivery For Tumor Thementioning

confidence: 99%

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Recent Advances in Biomaterial Scaffolds for Integrative Tumor Therapy and Bone Regeneration

Huang

Tian

Zhu

et al. 2020

Advanced Therapeutics

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Bone tumors bring great pain to patients, along with a high disability rate and high mortality. Several therapeutic strategies have been applied to treat bone tumors, such as chemotherapy, radiotherapy, and surgical resection. However, these strategies have intrinsic drawbacks, such as the serious side effects of chemotherapy or the necessary reconstructive surgery of surgical resection. To help develop more satisfactory bone tumor treatment strategies, biomaterial scaffolds have been proposed. Biomaterial scaffolds are often applied for repairing bone defects after surgical resection due to their biocompatibility, osteoinductivity, and osteoconductivity as well as excellent physicochemical properties. Simultaneously, the function of bone tumor therapy offers biomaterial scaffolds to eliminate residual tumor cells, thus avoiding tumor recurrence. This review summarizes recent advances in biomaterial scaffolds which are combined with chemotherapy or hyperthermia therapy for treating bone tumors and further bone regeneration. Moreover, the progress in synergistic therapy of bone tumors based on biomaterial scaffolds is also discussed. This review aims to inspire researchers to develop novel fabrication or functionalization strategies for constructing multifunctional biomaterial scaffolds with anti-tumor properties.

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Polysaccharide nanofibers and hydrogel: A comparative evaluation on 3D cell culture and tumor reduction

Usha

Jalajakumari

Sheela

et al. 2022

J of Applied Polymer Sci

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Nanofibers and hydrogels are two forms of biomaterial scaffolds that have different properties and different applications. Polysaccharides have been used for the preparation of both scaffolds due to their biocompatibility and biodegradability. In this study, our main objective was to compare the tumor cell growth and tumor reduction potential of drug‐loaded scaffolds. This was achieved using different methods for cell proliferation, epithelial–mesenchymal Transition studies, and biomarker expression‐related assays. Anticancer drug doxorubicin was loaded to the scaffolds using adsorption and in vitro and in vivo tumor reduction was also performed. Results showed that both scaffolds supported the growth of cancer cells but did not promote epithelial‐mesenchymal transition. A significant difference in drug release was observed and this may have influenced the in vivo tumor reduction. A fast release of the drug and higher tumor‐reducing potential was observed for hydrogel. The studies confirmed that different types of scaffolds have different properties. Biomedical applications related to the structure can be dissimilar in different scenarios.

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Doxorubicin eluting microporous polysaccharide scaffolds: An implantable device to expunge tumour

Cited by 12 publications

References 45 publications

A comprehensive study on 2D, 3D and solid tumor environment to explore a multifunctional biogenic nanoconjugate

A comprehensive study on 2D, 3D and solid tumor environment to explore a multifunctional biogenic nanoconjugate

Recent Advances in Biomaterial Scaffolds for Integrative Tumor Therapy and Bone Regeneration

Polysaccharide nanofibers and hydrogel: A comparative evaluation on 3D cell culture and tumor reduction

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