Doxorubicin induced cardiotoxicity is attenuated by metformin through improvements in mitochondrial stabilization

Asensio-López, M.C.; Sánchez-Más, Jesús; Pascual-Figal, Domingo; Abenza, S.; Pérez-Martínez, María T.; Pastor‐Pérez, Francisco J.; Garrido-Bravo, Iris P.; Valdés‐Chávarri, Mariano

doi:10.1093/eurheartj/eht309.p3248

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Small Molecules That Attenuate Dox-induced Cardiotoxicity1

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2024

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“…A study indicated that Met supplementation could attenuate the conduction abnormalities and mechanical dysfunction caused by Dox in rats [ 158 ]. Met plays an important role in cardiomyocytes by regulating the expression of transcription factor NF-κB, thereby protecting cardiomyocytes against Dox-induced oxidative stress and apoptosis [ 102 ]. Recently, Elashmawy et al showed that Met combined with Dox has a marked anti-tumorigenic effect [ 103 ].…”

Section: Small Molecules That Attenuate Dox-induced Cardiotoxicitymentioning

confidence: 99%

Mitochondria-Targeting Small Molecules Effectively Prevent Cardiotoxicity Induced by Doxorubicin

et al. 2018

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Doxorubicin (Dox) is a chemotherapeutic agent widely used for the treatment of numerous cancers. However, the clinical use of Dox is limited by its unwanted cardiotoxicity. Mitochondrial dysfunction has been associated with Dox-induced cardiotoxicity. To mitigate Dox-related cardiotoxicity, considerable successful examples of a variety of small molecules that target mitochondria to modulate Dox-induced cardiotoxicity have appeared in recent years. Here, we review the related literatures and discuss the evidence showing that mitochondria-targeting small molecules are promising cardioprotective agents against Dox-induced cardiac events.

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Section: Small Molecules That Attenuate Dox-induced Cardiotoxicitymentioning

confidence: 99%

Mitochondria-Targeting Small Molecules Effectively Prevent Cardiotoxicity Induced by Doxorubicin

et al. 2018

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Small Molecules Targeting Mitochondria: A Mechanistic Approach to Combating Doxorubicin-Induced Cardiotoxicity

Pal

2024

Cardiovasc Toxicol

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Doxorubicin induced cardio toxicity through sirtuins mediated mitochondrial disruption

Ahmad

Ullah

Chu

et al. 2022

Chemico-Biological Interactions

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Doxorubicin induced cardiotoxicity is attenuated by metformin through improvements in mitochondrial stabilization

Cited by 4 publications

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Mitochondria-Targeting Small Molecules Effectively Prevent Cardiotoxicity Induced by Doxorubicin

Mitochondria-Targeting Small Molecules Effectively Prevent Cardiotoxicity Induced by Doxorubicin

Small Molecules Targeting Mitochondria: A Mechanistic Approach to Combating Doxorubicin-Induced Cardiotoxicity

Doxorubicin induced cardio toxicity through sirtuins mediated mitochondrial disruption

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