Doxorubicin loaded ferritin nanoparticles for ferroptosis enhanced targeted killing of cancer cells

Yang, Ronghua; Li, Yaoqi; Wang, Xinyu; Yan, Junjie; Pan, Donghui; Xu, Yuping; Wang, Lizhen; Yang, Min

doi:10.1039/c9ra04478g

Cited by 39 publications

(28 citation statements)

References 33 publications

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“…In serendipitous fashion iron-based nanoparticles which were developed for other purposes also show anti-cancer potential. For instance, iron saturated ferritin nanoparticles loaded with doxorubicin induced ferroptotic death in cultures of leukemia, CRC, breast, liver, cervical, and lung cancer cells which overexpress TfR1 (247). Furthermore, iron-based nanoparticles which are already approved to treat iron deficiency, are used for imaging tumors and in preclinical studies as drug delivery carriers also show therapeutic benefit.…”

Section: Ferroptosismentioning

confidence: 99%

Altered Iron Metabolism and Impact in Cancer Biology, Metastasis, and Immunology

et al. 2020

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Iron is an essential nutrient that plays a complex role in cancer biology. Iron metabolism must be tightly controlled within cells. Whilst fundamental to many cellular processes and required for cell survival, excess labile iron is toxic to cells. Increased iron metabolism is associated with malignant transformation, cancer progression, drug resistance and immune evasion. Depleting intracellular iron stores, either with the use of iron chelating agents or mimicking endogenous regulation mechanisms, such as microRNAs, present attractive therapeutic opportunities, some of which are currently under clinical investigation. Alternatively, iron overload can result in a form of regulated cell death, ferroptosis, which can be activated in cancer cells presenting an alternative anti-cancer strategy. This review focuses on alterations in iron metabolism that enable cancer cells to meet metabolic demands required during different stages of tumorigenesis in relation to metastasis and immune response. The strength of current evidence is considered, gaps in knowledge are highlighted and controversies relating to the role of iron and therapeutic targeting potential are discussed. The key question we address within this review is whether iron modulation represents a useful approach for treating metastatic disease and whether it could be employed in combination with existing targeted drugs and immune-based therapies to enhance their efficacy.

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Section: Ferroptosismentioning

confidence: 99%

Altered Iron Metabolism and Impact in Cancer Biology, Metastasis, and Immunology

et al. 2020

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“…studied to enhance cancer treatment by triggering ferroptosis alone or in combination with a cargo treatment through the intracellular release of Fe 2+ upon degradation in lysosomes. Some examples are the exploration of doxorubicin-loaded ferritin NPs(Yang et al 2019), Fe 2+ -based metal organic frameworks(He et al 2020, Wan et al 2020, Xu et al 2020, Fenton-reactionacceleratable magnetic NPs (Fe3O4) simultaneously increasing Fe 2+ , Fe 3+ and H2O2(Shen et al 2018), or sulfasalazine-loaded mesoporous magnetic NPs for the simultaneous inhibition of cystine uptake and Fe 2+ release(Jiang et al 2020). Moreover, various non-metal-based NP carriers are also exploited to deliver cargo molecules aimed at inducing ferroptosis to sensitize targeted cells for treatment effect Guo et al, 2020,.…”

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confidence: 99%

Small variations in nanoparticle structure dictate differential cellular stress responses and mode of cell death

et al. 2019

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First and foremost, I would like to thank my main supervisor Maria L. Torgersen for asking me to come back to the department to do my PhD. We had worked very well together when I was an engineer in Kirsten's group, and the thought of continuing that collaboration and learning process was attractive. You have been a dedicated and steady project leader, you love your work and transmit your passion while working side-by-side in the lab, you are meticulous and always think two steps ahead. Thank you for guiding me through this work.I would also like to express my gratitude to Kirsten Sandvig, as my co-supervisor and former group leader, and Harald Stenmark, as my current group leader. You have both provided a comfortable and motivating work environment, inspiration, help and insight.I would like to acknowledge all my co-authors for excellent collaboration. A special thanks goes to Marzena Szwed for being so much more than a co-author. Working together with you was always a pleasure. To Nikolai Engedal, for your interesting ideas and opinions on autophagy. To Tore Skotland, Anders Øverbye and Tore-Geir Iversen, for advice and guidance in the world of nanoparticles.I would sincerely like to thank all the people that have made these years working in the lab fun and enjoyable. We have shared more than frustrations over experiments and the joy of good results. I cherish the time spent in your company and thank you for all the great conversations and dinner parties. Although I will miss you in everyday life, I truly appreciate the fact that our friendship extends far beyond the lab. Sascha, you are the best officemate I could ever have asked for. Your laughter is contagious, you join me for a little dance or song, you listen when I talk, and you care. Ulrikke and Maja, you are the sunshine of my workday. I'm extremely grateful for having your friendship at work, you are always compassionate and helpful. Work would be harder without your supportive smiles and encouraging words. Anthony and Andreas, thank you for all the coffee and ice-cream breaks, and for discussions not only regarding work but of life in general. You´re always supportive, full of life and leave me in a good mood. Chema, thank you for being so much more than technical support. You come with fresh pastry on the weekends, engage in birthday celebrations and provide support when needed. Marta, Krizia, Domenica, Maria, Marzena, you left the lab and the country, but never the heart. Thank you for choosing MCB as your place to go abroad. I miss having you around and look forward to we can travel and see each other again. The boot camp crew: Simona, Helene, Viola, Maxi-Lu, Silvana and Kia Wee, Wednesday nights will not be the same without your happy faces. Suffering together as Viola pushes for the next exercise, knowing that we all dream for the same VI delicious smell of Indian food that awaits with Kay. Thank you for always listening and encouraging me. It has become a highlight of my week. Anne-Grethe, chatting with you has always been entertaining. Anne and ...

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“…Unloaded ferritin nanoparticles showed almost no cytotoxicity to HT29 and thus were unable to initiate ferroptosis. 67 …”

Section: Nanoparticle-induced Mechanisms For Immunological Alterationsmentioning

confidence: 99%

Biomedical nanomaterials for immunological applications: ongoing research and clinical trials

et al. 2020

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Doxorubicin loaded ferritin nanoparticles for ferroptosis enhanced targeted killing of cancer cells

Abstract: DOX loaded ferritin selectively induces ferroptosis enhanced killing of transferrin receptor 1 overexpressed cancer cells.

Cited by 39 publications

References 33 publications

Altered Iron Metabolism and Impact in Cancer Biology, Metastasis, and Immunology

Altered Iron Metabolism and Impact in Cancer Biology, Metastasis, and Immunology

Small variations in nanoparticle structure dictate differential cellular stress responses and mode of cell death

Biomedical nanomaterials for immunological applications: ongoing research and clinical trials

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