Doxorubicin loaded magnetic gold nanoparticles for in vivo targeted drug delivery

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

“…Over the past decades, several nano-sized DDSs have been developed and applied by targeted drug delivery to cancer cells, such as liposomes, [4][5][6][7] polymeric micelles, [8][9][10][11] dendrimers, [12][13][14][15][16] carbon nanotubes, [17][18][19][20][21][22] inorganic nanoparticles, [23][24][25][26] and silica-based materials. [27][28][29][30][31] Among them, mesoporous silica nanoparticles (MSNs) have attracted much attention due to their unique physiochemical properties, such as large specific surface area and pore volume, controllable particle size, remarkable stability and biocompatibility, and high drug-loading capacity.…”

Delivery of a chemotherapeutic drug using novel hollow carbon spheres for esophageal cancer treatment

“…For observing the accumulation of HCSs in the tumor, at 6-h post-injection, the Cy5.5-HCS-Dox administrated mice were scanned using the In-Vivo FX Pro image station (Bruker, NY, USA) and quantified using the Multiplex software (Bruker). To verify the circulation time, blood from the Cy5.5-HCS-Dox injected mice was collected into a tube (precoated with an anticoagulant) at various time points (1,3,6,12,24,48,72,96, and 120 h). The intensity of Cy5.5 signal was measured using equal volumes of the blood samples by the In-Vivo FX Pro image station.…”

“…injected with either free Dox (100 µg) or HCS-Dox (Dox, 100 µg). Serum from the peripheral blood samples was collected after 3,6,12,24,48,72,96,120, and 144 h. For analyzing Dox distribution in different tissues, the Dox (100 µg) or HCS-Dox (Dox, 100 µg) injected mice were sacrificed after 24 h. The organs, including liver, spleen, heart, lung, kidney, brain, and intestine, were homogenized. The concentration of Dox in serum and organs was measured using the Agilent 1100 HPLC system (Agilent, CA, USA).…”

“…1,2 With advancements in nanotechnology, several types of nanoparticles have been exploited for potential use in cancer therapy and diagnosis. Inorganic nanoparticles including gold nanoparticles, 3,4 silver nanomaterials, 5,6 silica nanocarriers, 7,8 or iron oxide nanoparticles 9 have been widely investigated for potential clinical applications. The growing interest in the use of inorganic nanomaterials in medicine is owing to their size-and shape-controllable preparation.…”

Nanoparticles in biomedical applications

“…This review investigates other nanosystems such as metallic nanoparticles like gold (Au) [112][113][114][115][116][117][118][119][120][121][122][123][124][125][126][127][128][129][130] and silver (Ag) , bimetallic nanoparticles like iron cobalt (Fe-Co) [78][79][80][92][93][94][95][96][97]108,109] and iron platinum (Fe-Pt) [155][156][157][158][159][160][161][162][163][164][165][166][167][168][169][170][171][172] and metal oxides including titanium dioxide (TiO 2 ) [1...…”