Doxorubicin-loaded platelets conjugated with anti-CD22 mAbs: a novel targeted delivery system for lymphoma treatment with cardiopulmonary avoidance

Xu, Peipei; Zuo, Huaqin; Zhou, Rong-Fu; Wang, Fan; Liu, Xu; Ouyang, Jian; Chen, Bing

doi:10.18632/oncotarget.16871

Cited by 46 publications

(36 citation statements)

References 37 publications

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“…Platelets, and their secreted vesicles, are potential drug delivery vehicles [ 128 ]. Platelets have little effect on drug activity, and using them as drug delivery vehicles may reduce side effects [ 129 ]. The platelet-loaded drugs are protected from clearance and, thus, can circulate in blood for a relatively long time [ 130 ].…”

Section: Platelets a Potential Therapeutic Target And Biomarker Fmentioning

confidence: 99%

Human Cancer and Platelet Interaction, a Potential Therapeutic Target

Wang

2018

IJMS

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Cancer patients experience a four-fold increase in thrombosis risk, indicating that cancer development and progression are associated with platelet activation. Xenograft experiments and transgenic mouse models further demonstrate that platelet activation and platelet-cancer cell interaction are crucial for cancer metastasis. Direct or indirect interaction of platelets induces cancer cell plasticity and enhances survival and extravasation of circulating cancer cells during dissemination. In vivo and in vitro experiments also demonstrate that cancer cells induce platelet aggregation, suggesting that platelet-cancer interaction is bidirectional. Therefore, understanding how platelets crosstalk with cancer cells may identify potential strategies to inhibit cancer metastasis and to reduce cancer-related thrombosis. Here, we discuss the potential function of platelets in regulating cancer progression and summarize the factors and signaling pathways that mediate the cancer cell-platelet interaction.

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Section: Platelets a Potential Therapeutic Target And Biomarker Fmentioning

confidence: 99%

Human Cancer and Platelet Interaction, a Potential Therapeutic Target

Wang

2018

IJMS

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“…Gaucher's Disease [25] Thymidine phosphorylase Mitochondrial Neuro-gastrointestinal Encephalopathy (MNGIE) [26] Daunorubicin Acute Leukemia [27] Doxorubicin Lymphoma [28] Platelets -Readily available blood cells [22] -Lifespan of 8-10 days [29] -Site-specific activation/adhesion [29] Epidoxorubicin Myeloma [30] Doxorubicin Lymphoma [31,32] Factor VIII/Factor IX Hemophilia [33,34] ADAMTS13 (A Disintegrin and Metalloprotease with Thrombospondin Type 1 Repeats-13)…”

Section: Glucocerebrosidasementioning

confidence: 99%

Adipocyte-Based Cell Therapy in Oncology: The Role of Cancer-Associated Adipocytes and Their Reinterpretation as Delivery Platforms

et al. 2020

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Cancer-associated adipocytes have functional roles in tumor development through secreted adipocyte-derived factors and exosomes and also through metabolic symbiosis, where the malignant cells take up the lactate, fatty acids and glutamine produced by the neighboring adipocytes. Recent research has demonstrated the value of adipocytes as cell-based delivery platforms for drugs (or prodrugs), nucleic acids or loaded nanoparticles for cancer therapy. This strategy takes advantage of the biocompatibility of the delivery system, its ability to locate the tumor site and also the predisposition of cancer cells to come in functional contact with the adipocytes from the tumor microenvironment for metabolic sustenance. Also, their exosomal content can be used in the context of cancer stem cell reprogramming or as a delivery vehicle for different cargos, like non-coding nucleic acids. Moreover, the process of adipocytes isolation, processing and charging is quite straightforward, with minimal economical expenses. The present review comprehensively presents the role of adipocytes in cancer (in the context of obese and non-obese individuals), the main methods for isolation and characterization and also the current therapeutic applications of these cells as delivery platforms in the oncology sector.

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“…Platelets are bio- and immune-compatible drug carriers that can prolong the circulation time of drugs. Anti-CD22 mAb-labeled platelets can precisely deliver DOX to tumor cells [ 31 ]. It was found that the two platelet membrane proteins, GPIIb-IIIa intergrins and P-selectins, on the surface of the liposomes containing the adriamycin-coated platelets, allowed the drug carrier to specifically recognize the metastatic activity of breast cancer cells in the blood [ 32 ].…”

Section: Platelet Drug-loaded Systemmentioning

confidence: 99%

Platelet-inspired medicine for tumor therapy

Yang

Wang²,

Liu

et al. 2017

Oncotarget

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As the number of patients with tumor increases dramatically recent years, traditional therapies expose more and more problems which can even lead to death. Many researchers and clinicians quest for an efficient drug delivery system to deal with tumor as a result. With the researches further develop, we find that platelet can interact with tumor cells through a variety of ways. So it can be used as a carrier broadly to deliver different anti-tumor drugs for tumor treatment. In the present review, we summarize the interaction of tumor cells and platelet. At the same time, we focus on recent progress on the application of platelet drug-loaded system in the anti-tumor prospects.

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Doxorubicin-loaded platelets conjugated with anti-CD22 mAbs: a novel targeted delivery system for lymphoma treatment with cardiopulmonary avoidance

Cited by 46 publications

References 37 publications

Human Cancer and Platelet Interaction, a Potential Therapeutic Target

Human Cancer and Platelet Interaction, a Potential Therapeutic Target

Adipocyte-Based Cell Therapy in Oncology: The Role of Cancer-Associated Adipocytes and Their Reinterpretation as Delivery Platforms

Platelet-inspired medicine for tumor therapy

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