Doxorubicin loaded polymeric gold nanoparticles targeted to human folate receptor upon laser photothermal therapy potentiates chemotherapy in breast cancer cell lines

Banu, Hussaina; Sethi, Dipinder Kaur; Edgar, Andre; Sheriff, Adhnaan; Rayees, Nuthan; Renuka, N.K.; Faheem, Sultan M.; Premkumar, Kumpati; Vasanthakumar, Geetha

doi:10.1016/j.jphotobiol.2015.05.008

Cited by 111 publications

(56 citation statements)

References 62 publications

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“…Recently, combined cancer photothermal-chemotherapy based on gold nanoparticles has received increasing attention (Banu et al, 2015;Zhang et al, 2013). However, the potential toxicity and instability of gold nanoparticles-bearing chemotherapeutic agents cannot be belittled (Siddiqi et al, 2012;Caballero-D ıaz E & Valc arcel M, 2014).…”

Section: Discussionmentioning

confidence: 99%

Near infrared light mediated photochemotherapy for efficiently treating deep orthotopic tumors guided by ultrasound imaging

et al. 2017

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Recently, Combined cancer photothermal-chemotherapy has become a highly promising strategy in cancer treatment for its enhanced therapeutic efficacy, controlled drug release and reduced systemic toxicity. Almost all the reported strategies based on photothermal-chemotherapy have only focused on the treatment of superficial or subcutaneous cancer, which are not considered as a more clinically relevant and better predictive models of drug efficacy than orthotopic tumor models. Here, we reported an EphB4 receptor-targeting polymeric nanoplatform containing hollow gold nanospheres (HAuNS) and the anticancer drug paclitaxel (PTX) for cancer photothermal-chemotherapy. With the modification of the TNYL peptide, HP-TCS could specifically internalize into EphB4-positive SKOV3 and CT26 cells, further inducing the selective killing of the cells in co-cultured system, namely, EphB4-positive and EphB4-negative cells. Obvious targeting of the micelles into implanted orthotopic or subcutaneous tumors with high EphB4 expression was observed. Interestingly, increased accumulation of HP-TCS was observed in orthotopic colon tumors when compared with ectopic tumors. Highly specific accumulation of HP-TCS in EphB4-positive tumors significantly increased the feasibility of photothermal-chemotherapy mediated by the near infrared reflection (NIR) laser. Then, a systemic antitumor efficiency study was performed in implanted subcutaneous and visual orthotopic tumor models. Precise NIR laser irradiation could be localized on tumors under the guidance of B-mode ultrasound imaging, causing a rapid photothermal ablation effect limited to the region of tumors. Tumor growth was significantly inhibited by the photothermal-chemotherapy due to the triggered release of PTX. Our study provided a promising strategy of NIR laser-mediated photothermal-chemotherapy based on HP-TCS against the tumors (specially, deep orthotopic tumors) with high EphB4 expression. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Near infrared light mediated photochemotherapy for efficiently treating deep orthotopic tumors guided by ultrasound imaging

et al. 2017

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“…In the laser therapy group, the tumors grew at a slower rate, and in two cases the size of the tumors decreased. This indicates that the average size of tumor before and 3 days after the treatment was increased in the control group (from 406 mm 3 to 745.31 mm 3 , respectively), but these values decreased in the O-CNT-PEG group (from 566.4 mm 3 to 174.69 mm 3 , respectively). The P-value between all groups was significantly different after treatment.…”

mentioning

confidence: 91%

“…Internalized nanoparticles (NPs) to the tumor sites could be stimulated by laser irradiation, to produce localized heat in the range of 40°C-45°C so as to destroy cancer cells. [2][3][4][5] NPs such as single-walled carbon nanotubes, 6 multiwalled carbon nanotubes (MWNTs), 7,8 graphene, 9,10 iron oxide NPs, 11 gold nanorods, 12 and gold nanoshells 13,14 are used to transform NIR radiation to vibrational energy. Therefore, heat generation based on laser irritation could elevate malignant tissues' temperature and destroy tumors.…”

Section: Introductionmentioning

confidence: 99%

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Photothermal therapy of melanoma tumor using multiwalled carbon nanotubes

Sobhani¹,

Behnam²,

Emami³

et al. 2017

IJN

123

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Photothermal therapy (PTT) is a therapeutic method in which photon energy is transformed into heat rapidly via different operations to extirpate cancer. Nanoparticles, such as carbon nanotubes (CNTs) have exceptional optical absorbance in visible and near infrared spectra. Therefore, they could be a good converter to induce hyperthermia in PTT technique. In our study, for improving the dispersibility of multiwalled CNTs in water, the CNTs were oxidized (O-CNTs) and then polyethylene glycol (PEG) was used for wrapping the surface of nanotubes. The formation of a thin layer of PEG around the nanotubes was confirmed through Fourier transform infrared, thermogravimetric analysis, and field emission scanning electron microscopy techniques. Results of thermogravimetric analysis showed that the amount of PEG component in the O-CNT-PEG was approximately 80% (w/w). Cell cytotoxicity study showed that O-CNT was less cytotoxic than pristine multiwalled nanotubes, and O-CNT-PEG had the lowest toxicity against HeLa and HepG2 cell lines. The effect of O-CNT-PEG in reduction of melanoma tumor size after PTT was evaluated. Cancerous mice were exposed to a continuous-wave near infrared laser diode (λ=808 nm, P =2 W and I =8 W/cm 2 ) for 10 minutes once in the period of the treatment. The average size of tumor in mice receiving O-CNT-PEG decreased sharply in comparison with those that received laser therapy alone. Results of animal studies indicate that O-CNT-PEG is a powerful candidate for eradicating solid tumors in PTT technique.

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“…These include nanoparticles composed of iron oxide [1], gold [2], quantum dots [3], carbon nanotubes [4], silver nanoparticles [5] and many more. Hybrid nanoparticles (HNPs) composed of an iron oxide core surrounded by a gold shell have shown potential for image guided cancer therapy [6].…”

Section: Introductionmentioning

confidence: 99%

Heat Dissipation of Hybrid Iron Oxide-Gold Nanoparticles in an Agar Phantom

Curtis

Malekigorji

Holman

et al. 2015

J Nanomed Nanotechnol

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Hybrid iron oxide-gold nanoparticles (HNPs) have shown potential in cancer therapy as agents for tumour ablation and thermal switches for targeted drug release. Heat generation occurs by exploitation of the surface plasmon resonance of the gold coating, which usually occurs at the maximum UV absorption wavelength. However, lasers at such wavelength are often expensive and highly specialised. Here, we report the heating and monitoring of heat dissipation of HNPs suspended in agar phantoms using a relatively inexpensive Ng: YAG pulsed 1064 nm laser source. The particles experience heating of up to 40°C with a total area of heat dissipation up to 132.73 mm 2 from the 1 mm diameter irradiation point after 60 seconds. This work reports the potential and possible drawbacks of these particles for translation into cancer therapy based on our findings.

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Doxorubicin loaded polymeric gold nanoparticles targeted to human folate receptor upon laser photothermal therapy potentiates chemotherapy in breast cancer cell lines

Cited by 111 publications

References 62 publications

Near infrared light mediated photochemotherapy for efficiently treating deep orthotopic tumors guided by ultrasound imaging

Near infrared light mediated photochemotherapy for efficiently treating deep orthotopic tumors guided by ultrasound imaging

Photothermal therapy of melanoma tumor using multiwalled carbon nanotubes

Heat Dissipation of Hybrid Iron Oxide-Gold Nanoparticles in an Agar Phantom

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