Doxorubicin-Loaded Silica Nanocomposites for Cancer Treatment

Abstract

Silica nanoparticles (SiNPs) are a promising material for nanomedicine technology. SiNPs are considered a powerful tool for drug delivery, functional coatings and films, and biomolecule separation due to their stability, biocompatibility, and accessible surface modification. Herein, the synthesis of SiNPs and SiNPs nylon 6 (SiNPs-Nylon) coated nanocomposites was proposed. Transmission electron microscopy (TEM) and dynamic light scattering (DLS) were used for morphology, size, and stability analysis. Anticancer drug doxorubicin (DOX) loading to the nanocomposites and pH-dependent release experiments are presented. DOX-loaded nanocomposites with high drug capacities of up to 258 μg/mg (DOX/SiNPs) and 493 μg/mg (DOX/SiNPs-Nylon) show effective inhibition of A549 and HEK 293FT cell lines. The IC50 values were 0.08 ± 0.01 µM in terms of DOX amount and recalculated as 0.31 ± 0.04 µg/mL in terms of the concentration of SiNPs for the HEK 293FT cells. Therefore, silica nanocomposites have a high potential for cancer treatment.

Nylon-6-Coated Doxorubicin-Loaded Magnetic Nanoparticles and Nanocapsules for Cancer Treatment

“…The nanocomposites were obtained according to a four-step procedure (Figure 2). Their synthesis was carried out according to a procedure that was previously developed by the authors [16,18] consisting of the widely used tetraethyl orthosili-…”

“…Magnetochemistry 2023, 9, 106 2 of 16 However, efficient vehicle design for effective therapeutic drug delivery poses a significant challenge in clinical cancer treatment. Various nanoscale systems based on polymers, gold, calcium carbonate, silica, magnetic materials, biological components, or bioinspared have been proposed as controlled release methods for DOX [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21].…”

“…Particles smaller than 15 nm are removed from the blood through the kidneys, while those higher than 150 nm are absorbed by the liver and spleen and pose problems with vascular structures' penetration and cellular internalization. By combining nanotechnology and responsive DOX delivery systems, various nanocomposites can be synthesized, thus avoiding drug resistance problems [8,13,16,21].…”

“…Nylon-6 is widely used for the manufacture of medical materials [18,[61][62][63]. Nylon exhibits high chemical stability, amphiphilic properties, and excellent biocompatibility [16,61]. Due to its low density and ability to aggregate, nylon may form extensive porous structures, which may be a promising affordance in terms of drug loading [16,18,61].…”

“…Controlled drug release in a cancer tissue environment by a pH-stimuli-response is a well-known method with high prospects in this field [8,13,16,21]. pH-responsive constructions should have extremely low drug release properties in plasma (pH~7.4) and healthy tissue.…”