Doxorubicin‐loaded ultrafine PEG‐PLA fiber mats against hepatocarcinoma

Abstract

The purpose of this study was to evaluate both cytotoxicity in vitro and in vivo anticancer activities of implantable doxorubicin hydrocloride (Dox)-loaded diblock copolymer poly(ethylene glycol)-b-poly(L-lactic acid) (PEG-PLA) fiber mats (hereafter medicated mats). For in vitro evaluation, SMMC7721 cells were directly exposed to the medicated fiber mats, followed with MTT assay. For in vivo evaluation, the medicated mats were locally implanted into H22 tumor-bearing mice, followed with detection of Fas protein and flow cytometry analysis. The results showed that in vitro cytotoxicity of medicated fibers were sustained throughout the whole experiment process with the degradation of fiber matrix, while that of pure Dox was reduced in six days; medicated fibers had superior in vivo anticancer activities to pure Dox (P < 0.01). In conclusion, Doxorubicin-loaded PEG-PLA electrospun fiber mats had the properties of loading doxorubicin hydrochloride (Dox) and sustained release of Dox from medicated fiber matrix and apparently retained both in vitro cytotoxicity and in vivo anticancer activities in a long term. Medicated fiber mats are therefore suitable for a local therapy device.

PLGA nanofibers improves the antitumoral effect of daunorubicin

“…This would indicate that DNR may be entrapped physically in the polymer matrix, as observed elsewhere [46]. From a pharmaceutical perspective, a release in the form of an initial burst is required to promote a local antitumor effect in which the initial dose kills a majority of cancerous cells, whereas the subsequent controlled release prevents tumor cell growth and proliferation [47]. Moreover, due to the fact that extracellular compartments of solid tumors are more acidic than normal tissues, DNR release is favored by high rate of polymer hydrolysis [46].…”

Paclitaxel-loaded poly(glycolide-co-&epsilon;-caprolactone)-b-D-&alpha;-tocopheryl polyethylene glycol 2000 succinate nanoparticles for lung cancer therapy

“…30 PGA-co-PCL NPs can be rapidly removed by the reticuloendothelial system when they are intravenously injected into the body. 31,32 These drawbacks can be overcome by introduced D-α-tocopheryl polyethylene glycol (PEG) 2000 succinate (TPGS 2k ) to PGA, PCL, and PGA-co-PCL. 13,33 TPGS 2k , a water-soluble derivative of natural vitamin E, is formed by esterification of vitamin E succinate with PEG 2000.…”

Sustained Delivery of Doxorubicin via Acetalated Dextran Scaffold Prevents Glioblastoma Recurrence after Surgical Resection

“…This pattern of stagnant DXR release after an initial period of rapid release over the first few days is also seen in multiple polymer drug delivery platforms including polyanhydrides, 20 polyesters, 21, 22 and polyethylene glycol polyester composites. 23, 24 The therapeutic efficacy of interstitial GBM treatment could be greatly improved with sustained DXR release from an optimal polymer matrix.…”