Doxycycline‐Loaded β‐Tricalcium Phosphate Release Following EDTA Root Surface Etching Improved the Clinical Outcomes in Chronic Periodontitis: An In Vivo Study

Abstract

EDTA root surface etching enhances DOX availability in the GCF following its release from β-TCP as a drug carrier.

Guided tissue regeneration of intrabony defects with perforated barrier membranes, simvastatin, and EDTA root surface modification: A clinical and biochemical study

“…Group 3 and group 4 reported significantly higher PPD reduction and CAL gain compared with group 1 and group 2 with no significant difference between them. This finding could be related to EDTA root surface etching for both groups that could enhance SMV availability with its subsequent more sustained effects on soft tissue parameters . This assumption was supported by crevicular fluid evaluation which revealed significantly higher SMV concentration in group 3 and group 4 compared with groups 1 and 2.…”

“…40,41 Many studies reported positive results during the regeneration of periodontal bone defects after the application of SMV with methylcellulose gel. 30,31,42,43 This non-significant difference in pocket reduction between the two groups also ensures the 22,23 This assumption was supported by crevicular fluid evaluation which revealed significantly higher SMV concentration in group 3 and group 4 compared with groups 1 and 2. The non-significant differences between the two groups could reflect a maximum stimulatory effect of SMV in augmenting soft tissue parameters.…”

“…However, EDTA gel root surface etching claimed in many studies to improve graft availability, act as a non-space-occupying delivery vehicle, and improved significant drug substantivity to periodontally affected root surfaces without compromising regenerating tissues. [19][20][21][22][23] The main hypothesis behind this study is that using simvastatin within the defect could promote chemoattraction, osteoblastic differentiation, and increased collagen expression capacity of gingival cells with its associated gingival mesenchymal stem cells that was reported by the same group to be migrated through fibrin clot-occluded membrane perforations. 7,9,10 EDTA root surface etching with its known smear removal and selective demineralization effects 19 could improve SMV adsorption to the root surface improving its availability within the defect for more enhanced clinical effects.…”

“…Chemical root etching agents have been reported to induce no significant clinical benefit for the patient with respect to the reduction in probing depth (PD) or gain in clinical attachment level (CAL).However, EDTA gel root surface etching claimed in many studies to improve graft availability, act as a non‐space‐occupying delivery vehicle, and improved significant drug substantivity to periodontally affected root surfaces without compromising regenerating tissues …”

Influence of Doxycycline and InGaAlP Diode Laser at 660 nm Wavelength in the Treatment of Periodontitis Induced in Rats: In Vivo Study

“…These factors can be attributed to the effects of DOX, such as inhibition of MMPs (collagenase and gelatinase) and implementation of a positive impact on the bone repair process. In addition, it provides anti-inflammatory effects by suppressing the number of polymorphonuclear leukocytes and blocking the release of prostaglandin E2 (31)(32)(33). Another important factor is the way DOX is used, since authors stated that DOX gel is able to remain in the subgingival site for a minimum period of ten days, and its mechanism of action thus reduced the volume of the gingival crevicular fluid (GCF) and the transforming growth factor beta 1 (TGF-ß1), with improved clinical signs of inflammation, decreased probe depth and clinical gain of insertion (34,35).…”