Doxycycline poudrage: An old agent for a new technique

Hatata, Eman; Daabis, Rasha; Sabaa, Bassma M. El; Baess, Ayman Ibrahim; El-Rahman, Inas Ahmed Abd

doi:10.1016/j.ejcdt.2016.08.012

Cited by 4 publications

(1 citation statement)

References 49 publications

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“…Numerous studies had indicated comparable or greater success rates when bleomycin was used as a sclerosing agent compared to other chemical agents [1]. Doxycycline has been involved in many types of research for pleurodesis of MPEs and recurrent pneumothorax [14]. In the present study, we aimed to determine which of these chemical agents could perform efficient and safe pleurodesis and which of them is superior.…”

Section: Introductionmentioning

confidence: 98%

Pleurodesis Using Bleomycin Ampoules, Doxycycline Capsules and Povidone Iodine Solution in Patients with Malignant Pleural Effusion in Zagazig University Hospitals

Elsayed

Alawady

2022

Zagazig University Medical Journal

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Background: Malignant pleural effusions (MPEs) can occur due to practically any type of cancer. MPEs frequently impair quality of life. There are numerous techniques for managing MPEs; each drains the pleural space and relieves respiratory symptoms. Pleurodesis is described as the formation of a symphysis between two layers of pleura to avoid the recurrence of effusions. Numerous chemical compounds are being investigated for use in pleurodesis. The purpose of this research was to examine the medical pleurodesis results performed with three different chemical agents in order to determine the most effective one with the fewest side effects. Methods: This study enrolled 60 patients from the Medical Oncology department at Zagazig University Hospitals, Egypt between January 2021 and January 2022. All patients were with MPEs. We enlisted 60 patients, separated them into three groups of 20 each, and had them undergo medical pleurodesis with three different chemical agents in comparison: povidone-iodine, doxycycline, and bleomycin. Sex, age, side of the effusion, treatment outcome (success and failure), and adverse effects were analyzed. Results: After pleurodesis, findings were evaluated, and the final success rates were 80% for povidone-iodine, 75% for bleomycin, and 65% for doxycycline. Conclusions: When utilized appropriately, povidone-iodine, doxycycline, and bleomycin are practically similarly efficient and safe sclerosing agents. While the povidone-iodine and doxycycline are similarly efficient and secure as bleomycin as chemical agents for pleurodesis in cases of MPEs, they are less costly and more commonly available.

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Section: Introductionmentioning

confidence: 98%

Pleurodesis Using Bleomycin Ampoules, Doxycycline Capsules and Povidone Iodine Solution in Patients with Malignant Pleural Effusion in Zagazig University Hospitals

Elsayed

Alawady

2022

Zagazig University Medical Journal

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The role of pleurodesis in respiratory diseases

Mercer

Hassan

Rahman

2018

Expert Review of Respiratory Medicine

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Pleurodesis is used to obliterate the pleural space, most commonly in patients with symptomatic malignant pleural effusions but also in patients with benign effusions or pneumothorax. Areas covered: Traditionally, chemical pleurodesis has been undertaken at thoracoscopy or using instillation of a slurry through a chest drain. The optimum method of achieving pleurodesis, whether surgical or medical, has yet to be proven. Evidence in the different disease areas will be reviewed, along with ongoing trial evidence, which may change practice. Expert commentary: Newer methods of achieving pleurodesis are being introduced. Studies have shown that instilling sclerosing agents via an indwelling pleural catheter or introducing drug-eluting catheters are safe and effective ways of inducing pleurodesis. There is evidence that pleurodesis might increase in survival, especially after pleural infection, possibly due to activation of the immune system. Multiple studies are currently underway to answer some of these questions and the future landscape may be very different from the present.

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Modified thoracoscopic pleural cryo-biopsy in diagnosis of exudative pleural effusion of undetermined etiology

et al. 2021

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Background Rigid thoracoscopy is the gold standard tool for diagnosing exudative pleural effusion, but sometimes it is difficult to obtain sufficient biopsies using the conventional forceps. This study evaluated the efficacy, safety, and diagnostic value of a modified technique using cryoprobe to obtain pleural biopsies during thoracoscopy. Results This is a single-center prospective study in patients that underwent rigid thoracoscopy using conventional rigid forceps followed by a cryoprobe at the same setting after injection of subpleural mixture of adrenaline and xylocaine. Biopsies were reviewed by an independent pathologist; any complications were recorded, and all patients were followed-up post-procedure. Twenty-four patients (12 males; mean age was 56 ± 15.1years) were included. The diagnostic yield of both rigid forceps biopsy (RFB) and cryoprobe biopsy (CPB) was 100%. CPB had more surface area than RFB with no difference regarding largest diameter (p = 0.064). RFB and CPB had similar results regarding presence of fat cells. CPB had much less crushed cells than RFB with better tissue preservation (p = 0.004). No significant complications were reported. Conclusions The modified cryoprobe biopsy is a highly effective and safe way for obtaining pleural biopsy besides affording good quality and size of the biopsy especially in thick firmly adherent pleura.

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Doxycycline poudrage: An old agent for a new technique

Cited by 4 publications

References 49 publications

Pleurodesis Using Bleomycin Ampoules, Doxycycline Capsules and Povidone Iodine Solution in Patients with Malignant Pleural Effusion in Zagazig University Hospitals

Pleurodesis Using Bleomycin Ampoules, Doxycycline Capsules and Povidone Iodine Solution in Patients with Malignant Pleural Effusion in Zagazig University Hospitals

The role of pleurodesis in respiratory diseases

Modified thoracoscopic pleural cryo-biopsy in diagnosis of exudative pleural effusion of undetermined etiology

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