Doxycycline treatment of nongonococcal urethritis with special reference to T-strain mycoplasmas.

Lassus, A; Perko, R L; S, Stubb; Mattila, Rauni; Jansson, E

doi:10.1136/sti.47.2.126

Cited by 9 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, the danger in attributing too much significance to observations of an apparent curative effect on NGU of medication with antibiotics, to which T-mycoplasmas are susceptible, should be pointed out. This is amply illustrated by the report of L assus et al [103], amongst others, who, by treatment with doxycyline, obtained cure in 92% of T-mycoplasma-positive cases of NGU, and in 95% of T-mycoplasma-negative cases.…”

Section: Manmentioning

confidence: 88%

Present Status of the Medical Importance of Mycoplasmas

Ea¹

1974

Pathobiology

View full text Add to dashboard Cite

According to their tissue affinities and pathogenicity, the mycoplasmas may be placed into three maingroups: (1) those associated with respiratory tract infections; (2) those involved in infections of the urogenital tract; and (3) mycoplasmas showing a particular affinity for joint tissues.On the basis of this grouping, presently available data relating several Mycoplasma and Acholeplasma species with diseases of man and animals are critically reviewed. The importance of comparative studies in the field of mycoplasmal pathology is emphasized.

show abstract

Section: Manmentioning

confidence: 88%

Present Status of the Medical Importance of Mycoplasmas

Ea¹

1974

Pathobiology

View full text Add to dashboard Cite

show abstract

“…The favourable response of this disease to treatment with broadspectrum antibiotics, but not penicillin or other cell wall-inhibiting antibiotics (Lassus, Perko, Stubb, Mattila, and Jansson, 1971), coupled with the recovery of T-strain mycoplasmas approximately twice as frequently from NGU patients as from controls, has made the T-strain a likely candidate for the role of causative agent of this apparently venereally spread disease. However, the finding of T-strains in 20 to 48 per cent.…”

Section: Discussionmentioning

confidence: 99%

Mycoplasmas recovered from patients with urethritis.

Hill¹,

Philip²,

Greaves³

et al. 1973

Sexually Transmitted Infections

View full text Add to dashboard Cite

Of the many organisms isolated from patients with non-gonococcal urethritis (NGU) and post-gonococcal urethritis (PGU), mycoplasmas have received considerable attention. Recovery of mycoplasmas from urethral discharge in males was first reported by Smith (1942). Large-colony mycoplasmas, particularly Mycoplasma hominis, have been isolated frequently from cases of NGU. Studies investigating the role of M. hominis in NGU have indicated that it is probably associated with sexual promiscuity rather than disease (Hayflick and Chanock, 1965; Taylor-Robinson, Addey, Hare, and Dunlop, 1969). In contrast, the role of T-strain mycoplasmas in NGU and PGU is unclear.Several investigators have reported an association between T-strain mycoplasmas and NGU (Shepard, 1959; Ford, Rasmussen, and Minken, 1962; Ford, and Du Vernet, 1966; Csonka, Williams, and Corse, 1966;Jansson, Lassus, Stubb, and Tuuri, 1971); others have failed to detect such an association (Ingham, MacFarlane, Hale, Selkon, and Codd, 1966;Black and Rasmussen, 1968; Hare, Dunlop, and Taylor-Robinson, 1969;Fowler and Leeming, 1969;Haas, Dorfman, and Sacks, 1971 glucose with thallium pH 70; (4) Arginine broth-1 per cent. arginine with thallium pH 7-0. Transport medium consisted of veal infusion broth with 0-5 per cent. bovine serum albumin. Such medium was found to be at least as satisfactory as mycoplasma medium for storage of mycoplasmas at 0-4°C. M. hominis and T-strain mycoplasmas stored in transport medium at 4°C. retained full titre for at least 48 hrs.

show abstract

“…The first, by Lassus et al (1971), can be dismissed because no control group was invblved, the assessment time was too soon after the initial treatment, and the experiment was not rigorous. There was however one cautionary sentence (p. 129): 'The longer the follow-up period, the more difficult it is to judge correctly the treatment results, since spontaneous remissions and recurrences are more prone to interfere'.…”

Section: Introductionmentioning

confidence: 99%

Tetracycline treatment for non-specific urethritis

Simopoulos

1977

Sexually Transmitted Infections

View full text Add to dashboard Cite

Doxycycline treatment of nongonococcal urethritis with special reference to T-strain mycoplasmas.

Cited by 9 publications

References 25 publications

Present Status of the Medical Importance of Mycoplasmas

Present Status of the Medical Importance of Mycoplasmas

Mycoplasmas recovered from patients with urethritis.

Tetracycline treatment for non-specific urethritis

Contact Info

Product

Resources

About