DPPH and nitric oxide free radical scavenging potential of phenyl quinoline derivatives and their transition metal complexes

Tabassum, Rukhsana; Ashfaq, Muhammad; Tahir, Tehreem; Oku, Hiroyuki

doi:10.1016/j.molstruc.2022.134058

Cited by 5 publications

(2 citation statements)

References 74 publications

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“…DPPH radical scavenging activity was determined according to a reported method and was adapted to a 96-well flat bottom plate [ 19 ]. Each sample was mixed in a tube of 1 mL and transferred to the well.…”

Section: Methodsmentioning

confidence: 99%

The Hydrolysis of Pigment-Protein Phycoerythrin by Bromelain Enhances the Color Stability

Sun

Cui

Wang

et al. 2023

Foods

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Phycoerythrin (PE) is a natural protein–pigment complex with a strong pink color, but it is sensitive to thermal and light variations. In this study, PE was extracted from Porphyra haitanensis in a yield of 0.2% (w/w). The phycoerythrin hydrolysates (PEH) (3–10 kDa) were prepared by enzymatic hydrolysis of PE with bromelain (8000 U/g) at 47 °C for 30 min, with a degree of hydrolysis (DH) of 11.57 ± 0.39% and a color degradation rate of 7.98 ± 0.39%. The physicochemical properties of PEH were evaluated. The UV and fluorescence spectra indicated that bromelain changed the microenvironment around phycoerythrobilin (PEB). The infrared spectrum revealed that the bromelain hydrolysis increased the α-helix content of PEH. The scanning electron microscope showed that bromelain destroyed the dense and smooth structure of PE, resulting in irregular porous structures. The radical scavenging activities of DPPH and ABTS of PEH were increased relative to that of PE (p < 0.05). The thermal (40–80 °C)-, UV (0.5–3 h)-, visible light irradiation (2–8 h)-, and metal ion exposing stabilities of PEH were significantly improved (p < 0.05). This study provides a potential scheme for overcoming the sensitivity of PE to thermal and light variations and facilitates PEH as a natural colorant ingredient in food and pigment applications.

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Section: Methodsmentioning

confidence: 99%

The Hydrolysis of Pigment-Protein Phycoerythrin by Bromelain Enhances the Color Stability

Sun

Cui

Wang

et al. 2023

Foods

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“…Griess reagent was used to assess the production of nitric oxide (NO) radicals from the reaction of sodium nitroprusside with oxygen [21]. In brief, 10 mM sodium nitroprusside solution was added to various concentrations of the sample or Trolox solution and maintained at 25 • C for 150 min.…”

Section: Chemical-based Antioxidant Activity Assaysmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Mechanisms of Lipophilic Fractions from Polyscias fruticosa Leaves Based on Network Pharmacology, In Silico, and In Vitro Approaches

Rarison,

Truong,

Yoon

et al. 2023

Foods

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Polyscias fruticosa leaf (PFL) has been used in food and traditional medicine for the treatment of rheumatism, ischemia, and neuralgia. However, the lipophilic components of PFL and their biological properties remain unknown. This study, integrating network pharmacology analysis with in silico and in vitro approaches, aimed to elucidate the antioxidant and anti-inflammatory capacities of lipophilic extracts from PFL. A total of 71 lipophilic compounds were identified in PFL using gas chromatography–mass spectrometry. Network pharmacology and molecular docking analyses showed that key active compounds, mainly phytosterols and sesquiterpenes, were responsible for regulating core target genes, such as PTGS2, TLR4, NFE2L2, PRKCD, KEAP1, NFKB1, NR1l2, PTGS1, AR, and CYP3A4, which were mostly enriched in oxidative stress and inflammation-related pathways. Furthermore, lipophilic extracts from PFL offered powerful antioxidant capacities, as evident in our cell-free antioxidant assays. These extracts also provided a protection against oxidative stress by inducing the expression of catalase and heme oxygenase-1 in lipopolysaccharide (LPS)-treated RAW 264.7 cells. Additionally, lipophilic fractions from PFL showed anti-inflammatory potential in downregulating the level of pro-inflammatory factors in LPS-treated macrophages. Overall, these findings provide valuable insights into the antioxidant and anti-inflammatory properties of lipophilic extracts from PFL, which can be used as a fundamental basis for developing nutraceuticals and functional foods.

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Characterization of ionically crosslinked mango peel pectin-based films: Effect of different cations on the improved properties of film

Zhang

Pan

Zhao

et al. 2023

Food Packaging and Shelf Life

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DPPH and nitric oxide free radical scavenging potential of phenyl quinoline derivatives and their transition metal complexes

Cited by 5 publications

References 74 publications

The Hydrolysis of Pigment-Protein Phycoerythrin by Bromelain Enhances the Color Stability

The Hydrolysis of Pigment-Protein Phycoerythrin by Bromelain Enhances the Color Stability

Antioxidant and Anti-Inflammatory Mechanisms of Lipophilic Fractions from Polyscias fruticosa Leaves Based on Network Pharmacology, In Silico, and In Vitro Approaches

Characterization of ionically crosslinked mango peel pectin-based films: Effect of different cations on the improved properties of film

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