DPPH scavenging activity of some Bis-benzimidazole derivatives

Ouaket, Amine; Moughaoui, Fatiha; Laaraibi, Asmae; Hamdouch, Souad; Berrada, M.; Knouzi, N.

doi:10.13171/mjc8219041101ao

Cited by 4 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The percentage of discoloration was calculated as follows:

% Scavenging DPPH Free radical = 100 \times (1 - \frac{italicAE}{italicAD})

where AE, is the absorbance of the solution after adding the extract and AD is the absorbance of the blank DPPH solution. Ascorbic acid was used as a reference compound [42–46].…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

An efficient protocol for the synthesis of substituted 5‐amino pyrazole bearing benzo[d]imidazolone Core and their antioxidant activity

Sanghavi

Kher²,

Kapadiya

2023

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

An efficient, facile and regioselective route has been utilized for the synthesis of novel series of 5-(5-amino-1H-pyrazol-3-yl)-1,3-dimethyl-1,3-dihydro-2Hbenzo[d]imidazol-2-one derivatives (5a-l). The methyl 3,4-diaminobenzoate (1) used CDI/DMF system for the cyclization to benzimidazolone followed by Nmethylation and next ACN/n-BuLi media at À70 C to afford high yielded key intermediate, 3-(1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-3-oxopropanenitrile (4). The final adducts synthesis involved catalytic optimization to generate 5-amino pyrazole-based adducts (5a-l) rather than 3-amino pyrazole (6a-l) are discussed. Chromatographic and spectral techniques ( 1 H & 13C NMR, LC-MS, elemental analysis) confirmed the newly synthesized structures and were evaluated for antioxidant activity using DPPH free radical scavenging assay. The entire compounds showed extra (higher) potency against used standard ascorbic acid except 5j (2-F Ph substituent) while, 5c (ÀEt substitution) was found to be most potent among others.

show abstract

“…The percentage of discoloration was calculated as follows:

% Scavenging DPPH Free radical = 100 \times (1 - \frac{italicAE}{italicAD})

where AE, is the absorbance of the solution after adding the extract and AD is the absorbance of the blank DPPH solution. Ascorbic acid was used as a reference compound [42–46].…”

Section: Methodsmentioning

confidence: 99%

“…where AE, is the absorbance of the solution after adding the extract and AD is the absorbance of the blank DPPH solution. Ascorbic acid was used as a reference compound [42][43][44][45][46].…”

Section: In-vitro Antioxidant Assaymentioning

confidence: 99%