DR3 regulation of apoptosis of naive T-lymphocytes in children with acute infectious mononucleosis

Abstract

Acute infectious mononucleosis (AIM) is a widespread viral disease that mostly affects children. Development of AIM is accompanied by a change in the ratio of immune cells. This is provided by means of different biological processes including the regulation of apoptosis of naive T-cells. One of the potential regulators of apoptosis of T-lymphocytes is a death receptor 3 (DR3). We have studied the role of DR3 in the regulation of apoptosis of naive CD4 + (nTh) and CD8 + (nCTL) T-cells in healthy children and children with AIM. In healthy children as well as in children with AIM, the activation of DR3 is accompanied by inhibition of apoptosis of nTh. In healthy children, the stimulation of DR3 resulted in the increase in apoptosis of nCTL. On the contrary, in children with AIM, the level of apoptosis of nCTL decreased after DR3 activation, which is a positive contribution to the antiviral immune response. In children with AIM, nCTL are characterized by reduced level of apoptosis as compared with healthy children. These results indicate that DR3 can be involved in the reduction of sensitivity of nCTL to apoptosis in children with AIM.

Splenic rupture associated with thrombocytopenic purpura caused by infectious mononucleosis. Case report

“…The onset may be abrupt, but usually prodromal symptoms occur such as chills, diaphoresis, low-grade fever, anorexia, and malaise (4,5). Fever occurs in more than 90% of patients with MI, usually showing peaks during the afternoon with values of 38-39°C, although they can be up to 40°C; in most cases, the fever resolves within a period of 10 to 14 days (6,7,8).…”

“…This procedure was called the Paul-Bunnell test; it was the first serological test developed for this disease, and is currently used to establish a diagnosis. Heterophile antibodies receive this name because they can react with antigens from unrelated species (8,13).…”

Role of Cd95 and Dr3 Receptors in Na Ve T-Lymphocytes Apoptosis in Children With Infectious Mononucleosis During Convalescence

“…На момент забора материала у детей не выявлялись клинические и лабораторные признаки ИМ. В качестве груп-пы сравнения выступали те же дети, которые обследовались нами ранее в период развития острого ИМ, а также условно здоровые дети со-поставимого пола и возраста (результаты опу-бликованы в предыдущих работах) [5,8].…”

“…При остром ИМ наблюдали снижение уровня апоптоза нЦТЛ после активации рецеп-торов CD95 и DR3. Уровень апоптоза нТх при заболевании не изменялся [5,8]. Функциональ-ная направленность рецепторов CD95 и DR3 в отношении наивных Т-лимфоцитов детей с ИМ в период реконвалесценции не известна.…”

“…-клетках при специфической активации рецептора [8]. Таким образом, в период выздо-ровления резко падает антиапоптотическая роль рецептора DR3 в составе нТх.…”