Draft Genome Sequence of
            <i>Aspergillus awamori</i>
            IFM 58123
            <sup>NT</sup>

Shimizu, Masaaki; Kusuya, Yoko; Alimu, Yikelamu; Bian, Cai; Takahashi, Hiroki; Yaguchi, Takashi

doi:10.1128/mra.01453-18

Cited by 5 publications

(1 citation statement)

References 9 publications

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“…Full-length AoxB is marginally shorter at the N-terminus than the ubiquitous AoxA protein (351 AA), there where the mitochondrial target sequence is located. This full-length allele is also present in the sibling species A. welwitschiae [47] (5 strains) and A. awamori IFM 58123 [48], in addition to 14 genome-sequenced Aspergillus niger sensu stricto strains. The genome sequences of "Penicillium fimorum" strain S/N-308-OC-P1 (Master accession number JACVQR) are likely contaminated with the DNA of an A. niger-like fungus, specifying two non-identical aoxA genes and one full-length aoxB orthologue.…”

Section: Multiple Alleles For the Acquired Aoxb Paralogue In The Aspe...mentioning

confidence: 93%

Mutations in the Second Alternative Oxidase Gene: A New Approach to Group Aspergillus niger Strains

Flipphi

Márton

Bíró

et al. 2023

JoF

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Alternative oxidase is a terminal oxidase in the branched mitochondrial electron transport chain of most fungi including Aspergillus niger (subgenus Circumdati, section Nigri). A second, paralogous aox gene (aoxB) is extant in some A. niger isolates but also present in two divergent species of the subgenus Nidulantes—A. calidoustus and A. implicatus—as well as in Penicillium swiecickii. Black aspergilli are cosmopolitan opportunistic fungi that can cause diverse mycoses and acute aspergillosis in immunocompromised individuals. Amongst the approximately 75 genome-sequenced A. niger strains, aoxB features considerable sequence variation. Five mutations were identified that rationally affect transcription or function or terminally modify the gene product. One mutant allele that occurs in CBS 513.88 and A. niger neotype strain CBS 554.65 involves a chromosomal deletion that removes exon 1 and intron 1 from aoxB. Another aoxB allele results from retrotransposon integration. Three other alleles result from point mutations: a missense mutation of the start codon, a frameshift, and a nonsense mutation. A. niger strain ATCC 1015 has a full-length aoxB gene. The A. niger sensu stricto complex can thus be subdivided into six taxa according to extant aoxB allele, which may facilitate rapid and accurate identification of individual species

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Section: Multiple Alleles For the Acquired Aoxb Paralogue In The Aspe...mentioning

confidence: 93%

Mutations in the Second Alternative Oxidase Gene: A New Approach to Group Aspergillus niger Strains

Flipphi

Márton

Bíró

et al. 2023

JoF

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Telomere-to-telomere genome sequence of the model mould pathogen Aspergillus fumigatus

et al. 2022

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The pathogenic fungus Aspergillus fumigatus is a major etiological agent of fungal invasive and chronic diseases affecting tens of millions of individuals worldwide. Draft genome sequences of two clinical isolates (Af293 and A1163) are commonly used as reference genomes for analyses of clinical and environmental strains. However, the reference sequences lack coverage of centromeres, an accurate sequence for ribosomal repeats, and a comprehensive annotation of chromosomal rearrangements such as translocations and inversions. Here, we used PacBio Single Molecule Real-Time (SMRT), Oxford Nanopore and Illumina HiSeq sequencing for de novo genome assembly and polishing of two laboratory reference strains of A. fumigatus, CEA10 (parental isolate of A1163) and its descendant A1160. We generated full length chromosome assemblies and a comprehensive telomere-to-telomere coverage for CEA10 and near complete assembly of A1160 including ribosomal repeats and the sequences of centromeres, which we discovered to be composed of long transposon elements. We envision these high-quality reference genomes will become fundamental resources to study A. fumigatus biology, pathogenicity and virulence, and to discover more effective treatments against diseases caused by this fungus.

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Current status of secondary metabolite pathways linked to their related biosynthetic gene clusters in Aspergillus section Nigri

et al. 2023

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Draft Genome Sequence of Aspergillus awamori IFM 58123 ^NT

Abstract: Species of the Aspergillus section Nigri are taxonomically very complex. The taxonomic assignment of Aspergillus awamori is unclear.

Cited by 5 publications

References 9 publications

Mutations in the Second Alternative Oxidase Gene: A New Approach to Group Aspergillus niger Strains

Mutations in the Second Alternative Oxidase Gene: A New Approach to Group Aspergillus niger Strains

Telomere-to-telomere genome sequence of the model mould pathogen Aspergillus fumigatus

Current status of secondary metabolite pathways linked to their related biosynthetic gene clusters in Aspergillus section Nigri

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Draft Genome Sequence of Aspergillus awamori IFM 58123 NT

Abstract: Species of the Aspergillus section Nigri are taxonomically very complex. The taxonomic assignment of Aspergillus awamori is unclear.

Cited by 5 publications

References 9 publications

Mutations in the Second Alternative Oxidase Gene: A New Approach to Group Aspergillus niger Strains

Mutations in the Second Alternative Oxidase Gene: A New Approach to Group Aspergillus niger Strains

Telomere-to-telomere genome sequence of the model mould pathogen Aspergillus fumigatus

Current status of secondary metabolite pathways linked to their related biosynthetic gene clusters in Aspergillus section Nigri

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Draft Genome Sequence of Aspergillus awamori IFM 58123 ^NT