Draft Genome Sequence of Kytococcus schroeteri Strain H01, Isolated from Human Skin

Boukerb, Amine M.; Robert, Magalie; Teteneva, N. A.; Danilova, N.D.; Журина, М. В.; Mart’yanov, S. V.; Плакунов, В. К.; Feuilloley, Marc; Ганнесен, А. В.

doi:10.1128/mra.01081-19

Cited by 7 publications

(5 citation statements)

References 6 publications

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“…The genus is now known to include three species, K. schreoteri, K. sedentarius and K. aerolatus . There may be more unclassified and uncultured variants [ 3 ]. Kytococcus schroeteri was first identified by 16S rDNA analysis in 2002 in a patient with prosthetic valve endocarditis [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…Kytococcus schroeteri was first identified by 16S rDNA analysis in 2002 in a patient with prosthetic valve endocarditis [ 2 ]. It is usually a commensal [ 3 ] but can be pathogenic in patients with implants/prosthesis or immunocompromised patients. Identification of Kytococcus is not possible with manual methods or with automated identification systems.…”

Section: Discussionmentioning

confidence: 99%

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A case of Kytococcus schroeteri prosthetic valve endocarditis in a patient with COVID-19 infection

Shah¹,

Thakkar²,

Poojary³

et al. 2023

Indian Journal of Medical Microbiology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A case of Kytococcus schroeteri prosthetic valve endocarditis in a patient with COVID-19 infection

Shah¹,

Thakkar²,

Poojary³

et al. 2023

Indian Journal of Medical Microbiology

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“…K. schroeteri H01 was isolated from the skin of a healthy volunteer as described previously, characterized, and stored in the UNIQUEM Collection under the number UQM41482 [4,32]. The bacterium was stored and prepared for the experiments as described elsewhere [19].…”

Section: Strains and Cultivationmentioning

confidence: 99%

“…The first is a poorly investigated coccus, which did not have a complete genome reference in the NCBI database when the current study was finished. The only draft genome assembly was performed in 2019 for our strain H01 [4]. Scattered data on examples of bacteremia caused by K. schroeteri [5] reveal only the fact that this microorganism is able to cause rare infections, mostly in patients with attenuated immunity.…”

Section: Introductionmentioning

confidence: 99%

A-Type Natriuretic Peptide Alters the Impact of Azithromycin on Planktonic Culture and on (Monospecies and Binary) Biofilms of Skin Bacteria Kytococcus schroeteri and Staphylococcus aureus

Diuvenji,

Nevolina,

Solovyev

et al. 2023

Microorganisms

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It has been established that the human atrial natriuretic peptide is able to alter the effect of azithromycin on Kytococcus schroeteri H01 and Staphylococcus aureus 209P monospecies and binary biofilms. The effect of the hormone depends on the surface type and cultivation system, and it may have both enhancing and counteracting effects. The antagonistic effect of the hormone was observed mostly on hydrophobic surfaces, whereas the additive effect was observed on hydrophilic surfaces like glass. Also, the effect of the hormone depends on the antibiotic concentration and bacterial species. The combination of azithromycin and ANP led to an amplification of cell aggregation in biofilms, to the potential increase in matrix synthesis, and to a decrease in S. aureus in the binary community. Also, ANP, azithromycin, and their combinations caused the differential expression of genes of resistance to different antibiotics, like macrolides (mostly increasing expression in kytococci), fluoroquinolones, aminoglycosides, and others, in both bacteria.

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“…Kytococci are aerobic, catalase-positive bacteria that form yellow colonies on agar [ 2 ]. The genus is now known to include three species, K. schreoteri, K. sedentarius and K. aerolatus , though the taxonomy browser of NCBI reports more unclassified and uncultured variants [ 3 ]. K. schroeteri is a natural and common inhabitant of human skin flora.…”

Section: Introductionmentioning

confidence: 99%

Insight into Kytococcus schroeteri Infection Management: A Case Report and Review

Bagelman

Zvigule-Neidere

2021

Infectious Disease Reports

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Background: Kytococcus schroeteri is a member of normal skin microflora, which can cause lethal infections in immunosuppressed hosts. In this review we attempted to draw patterns of its pathogenicity, which seem to vary regarding host immune status and the presence of implantable devices. Evidence suggests this pathogen houses many resistance-forming proteins, which serve to exacerbate the challenge in curing it. Available information on K. schroeteri antibacterial susceptibility is scarce. In this situation, a novel, genome-based antibiotic resistance analysis model, previously suggested by Su et al., could aid clinicians dealing with unknown infections. In this study we merged data from observed antibiotic resistance patterns with resistance data demonstrated by DNA sequences. Methods: We reviewed all available articles and reports on K. schroeteri, from peer-reviewed online databases (ClinicalKey, PMC, Scopus and WebOfScience). Information on patients was then subdivided into patient profiles and tabulated independently. We later performed K. schroeteri genome sequence analysis for resistance proteins to understand the trends K. schroeteri exhibits. Results: K. schroeteri is resistant to beta-lactams, macrolides and clindamycin. It is susceptible to aminoglycosides, tetracyclines and rifampicin. We combined data from the literature review and sequence analysis and found evidence for the existence of PBP, PBP-2A and efflux pumps as likely determinants of K. schroeteri. Conclusions: Reviewing the data permits the speculation that baseline immune status plays a role in the outcome of a Kytococcal infection. Nonetheless, our case report demonstrates that the outcome of a lower baseline immunity could still be favorable, possibly using rifampicin in first-line treatment of infection caused by K. schroeteri.

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Draft Genome Sequence of Kytococcus schroeteri Strain H01, Isolated from Human Skin

Cited by 7 publications

References 6 publications

A case of Kytococcus schroeteri prosthetic valve endocarditis in a patient with COVID-19 infection

A case of Kytococcus schroeteri prosthetic valve endocarditis in a patient with COVID-19 infection

A-Type Natriuretic Peptide Alters the Impact of Azithromycin on Planktonic Culture and on (Monospecies and Binary) Biofilms of Skin Bacteria Kytococcus schroeteri and Staphylococcus aureus

Insight into Kytococcus schroeteri Infection Management: A Case Report and Review

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