The Clinical Manifestation Journey of Covid-19 is unpredictable, even after antiviral treatment. Favipiravir is one of the promising antivirals that is expected to stop the development of the disease so that it can eliminate the clinical symptoms of Covid-19. The question is to what extent the drug Favipiravir can do it, therefore this article's objective was to identify the clinical manifestation after Favipiravir treatment at Covid-19 subjects in 3 location studies in Indonesia. This study was a part of the main study related to the clinical trial of the efficacy and safety of Favipiravir for Subjects with moderate Covid-19. The study was conducted 2 times in 2020 and 2021 in 3 main hospitals with Covid-19 patients who came and were hospitalized as a population study. Age > 18 -59 years old, with Covid-19 confirmation by PCR, voluntary and signed informed consent were inclusion criteria with pregnant women, and lactation and allergy were exclusion criteria. Favipiravir was given a maximum at day 14 plus another standard of care. A total of 66 cases were recruited in this study on day 1 but the number of samples continues to decrease as they are discharged from the hospital, with reduce 15,2% on day 7 and 57.6% on day 14. The result on Day 1 before taking Favipiravir showed 30% cases of fever, 75.