2013
DOI: 10.12659/ajcr.889703
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DRESS syndrome following ciprofloxacin exposure: An unusual association

Abstract: Patient: Female, 24Final Diagnosis: DRESS syndromeSymptoms: Fever • rash • facial and body swelling • muscular pain • diarrheaMedication: CiprofloxacinClinical Procedure: —Specialty: Internal Medicine • HematologyObjective:Unusual or unexpected effect of treatmentBackground:Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a rare, potentially life-threatening drug reaction with a mean latency period of 3.9 weeks. It has been described in association with many medications; yet, Ciprofloxacin was … Show more

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Cited by 27 publications
(19 citation statements)
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“…Antibiotics-beta-lactams, sulfonamides, minocycline, ciprofloxacin [12], nitrofurantoin [13], azithromycin, linezolid [14] Antituberculosis medications-rifampin, amikacin [15,16] Proton pump inhibitors [17] Immunomodulators-cyclosporine, lenalidomide [18], leflunomide [19], dapsone, pentoxyphylline [20], sulfasalazine…”
Section: Risk Factorsmentioning
confidence: 99%
“…Antibiotics-beta-lactams, sulfonamides, minocycline, ciprofloxacin [12], nitrofurantoin [13], azithromycin, linezolid [14] Antituberculosis medications-rifampin, amikacin [15,16] Proton pump inhibitors [17] Immunomodulators-cyclosporine, lenalidomide [18], leflunomide [19], dapsone, pentoxyphylline [20], sulfasalazine…”
Section: Risk Factorsmentioning
confidence: 99%
“…To our knowledge there are only two cases that developed DRESS after ciprofloxacin treatment, published in 2010 and 2011. 5,6 In DRESS the spectrum of skin lesions may vary from maculopapular eruptions to TEN. 4 In our case, DRESS developed on the 3 rd day of the ciprofloxacin treatment and we evaluated the skin lesions as TEN for both histopathological and clinical features.…”
Section: Discussionmentioning
confidence: 99%
“…1,5,6 Here, a young woman who used oral ciprofloxacin for nasal discharge, diarrhoea, vomiting, and developed TEN and consequently DRESS with the addition of systemic symptoms is presented.…”
Section: Dress Syndrome Due To Ciprofloxacin Usementioning
confidence: 99%
“…5,10 In the long-term, there may be an association with autoimmune events. 4,6 Anticonvulsants are the most frequently involved drugs [4][5][6] , with few reports of cases induced by fluoroquinolones 11,12 Criteria No Yes Unknown .…”
Section: -3mentioning
confidence: 99%
“…11,12 Furthermore, the possibility that the syndrome was induced by metronidazole cannot be ruled out, even though it is unlikely given the scant evidence for this association in the literature.…”
Section: -3mentioning
confidence: 99%