Drimane Sesquiterpenoids and Isochromone Derivative from the Endophytic Fungus Pestalotiopsis sp. M-23

Kuang, Ce; Jing, Shu-Xi; Liu, Yan; Luo, Shi‐Hong; Li, Shenghong

doi:10.1007/s13659-016-0094-6

Cited by 13 publications

(5 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…M-23, an endophytic fungus of Leucosceptrum canum. Compound 361 displayed poor inhibitory effect against B. subtilis with IC 50 value of 280.27 µM [159].…”

Section: Pestalotiopsismentioning

confidence: 99%

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

View full text Add to dashboard Cite

Antibiotic resistance is becoming a burning issue due to the frequent use of antibiotics for curing common bacterial infections, indicating that we are running out of effective antibiotics. This has been more obvious during recent corona pandemics. Similarly, enhancement of antimicrobial resistance (AMR) is strengthening the pathogenicity and virulence of infectious microbes. Endophytes have shown expression of various new many bioactive compounds with significant biological activities. Specifically, in endophytic fungi, bioactive metabolites with unique skeletons have been identified which could be helpful in the prevention of increasing antimicrobial resistance. The major classes of metabolites reported include anthraquinone, sesquiterpenoid, chromone, xanthone, phenols, quinones, quinolone, piperazine, coumarins and cyclic peptides. In the present review, we reported 451 bioactive metabolites isolated from various groups of endophytic fungi from January 2015 to April 2021 along with their antibacterial profiling, chemical structures and mode of action. In addition, we also discussed various methods including epigenetic modifications, co-culture, and OSMAC to induce silent gene clusters for the production of noble bioactive compounds in endophytic fungi.

show abstract

“…M-23, an endophytic fungus of Leucosceptrum canum. Compound 361 displayed poor inhibitory effect against B. subtilis with IC 50 value of 280.27 µM [159].…”

Section: Pestalotiopsismentioning

confidence: 99%

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

View full text Add to dashboard Cite

show abstract

“…However, there are numerous reported DTSs with diverging changes on their B ring ( 31 – 34 and 36 – 37 ). For these molecules, specific enzymes catalysing epoxidations, hydroxylations and reductions can possibly cause double bonds to disappear or shift, as it may be suggested from the isolation of the above mentioned 8 – 10 from Penicillium sp., [16] sulphureuine 11 – 13 from Laetiporus sulphureus , and the lactone‐containing derivatives 24 , 37 and 38 from Pestalotiopsis sp., [24b] as well as chaetothyrins ( 28 , 29 , and 33 ) from Chaetothyriales sp [20d] . Nonetheless, the biosynthesis of alternative bicyclic sesquiterpenes must be considered; in particular, some structures containing a Δ 6,7 ‐double bond may come from still uncharacterized synthases.…”

Section: Biosynthesis Of Fungal Drimane‐type Sesquiterpene Backbonesmentioning

confidence: 99%

Chemical Diversity and Biosynthesis of Drimane‐Type Sesquiterpenes in the Fungal Kingdom

Huang

Valiante

2022

ChemBioChem

View full text Add to dashboard Cite

Drimane-type sesquiterpenes are a class of compounds produced by a wide range of organisms, initially isolated and characterized in plants. Meanwhile, in the past 20-30 years, a large number of novel structures from many divergent fungi have been elucidated. Recently, the biosynthesis of drimane-type sesquiterpenes and their esters has been explained in two filamentous fungi, namely Aspergillus oryzae and Aspergillus calidoustus, disclosing the basic biosynthetic principles needed to identify similar pathways in the fungal kingdom.

show abstract

“…IQ-011 cuautepestalorin, cytosporin M, cytosporin N, oxopestalochromane, pestalone inhibitory properties against α-glucosidase from S. cerevisiae [159] Pestalotiopsis sp. M-23 drimane sesquiterpenoids, 2α-hydroxyisodrimeninol, a new isochromone derivative weak antibacterial [160] Pestalotiopsis sp. PSU-MA69 pestalochromones A-C, pestalotethers A-D, pestaloxanthone, pestalolide antifungal activity against Candida albicans and Cryptococcus neoformans [161] Pestalotiopsis sp.…”

Section: Fungal Species Metabolites Bioactivity Referencesmentioning

confidence: 99%

Pestalotiopsis Diversity: Species, Dispositions, Secondary Metabolites, and Bioactivities

Wang²,

Yang³

2022

Molecules

View full text Add to dashboard Cite

Pestalotiopsis species have gained attention thanks to their structurally complex and biologically active secondary metabolites. In past decades, several new secondary metabolites were isolated and identified. Their bioactivities were tested, including anticancer, antifungal, antibacterial, and nematicidal activity. Since the previous review published in 2014, new secondary metabolites were isolated and identified from Pestalotiopsis species and unidentified strains. This review gathered published articles from 2014 to 2021 and focused on 239 new secondary metabolites and their bioactivities. To date, 384 Pestalotiopsis species have been discovered in diverse ecological habitats, with the majority of them unstudied. Some may contain secondary metabolites with unique bioactivities that might benefit pharmacology.

show abstract

Drimane Sesquiterpenoids and Isochromone Derivative from the Endophytic Fungus Pestalotiopsis sp. M-23

Cited by 13 publications

References 25 publications

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Chemical Diversity and Biosynthesis of Drimane‐Type Sesquiterpenes in the Fungal Kingdom

Pestalotiopsis Diversity: Species, Dispositions, Secondary Metabolites, and Bioactivities

Contact Info

Product

Resources

About