Drimanes from Drimys brasiliensis with leishmanicidal and antimalarial activity

Claudino, Vanessa D.; Silva, Kesia Caroline da; Filho, Valdir Cechinel; Yunes, Rosendo A.; Monachè, Franco Delle; Giménez, Alberto; Salamanca, Efraín; Gutierrez-Yapu, David; Malheiros, Ângela

doi:10.1590/0074-0276108022013002

Cited by 23 publications

(16 citation statements)

References 13 publications

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“…Another study also reported potent anti-Leishmanicidal activity for several polygodial derivatives as well as anti-malarial activity against Plasmodium falciparum. 33 We were unable to find similar reports of Giardial growth inhibitory activity for polygoidal. However, the inhibitory activity against other protozoal parasites indicates that polygodial may be responsible, at least in part, for the Giardial growth inhibition reported here.…”

Section: Discussionmentioning

confidence: 74%

Phytochemical Analysis of Tasmannia lanceolata Extracts and Inhibition of Giardia duodenalis Proliferation

Rayan¹,

Matthews²,

Donnell³

et al. 2016

Phcogj

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Background: Giardiasis is a debilitating disease caused by gastrointestinal parasites of the genus Giardia. Tasmannia lanceolata (Tasmanian pepper berry) has a high anti-oxidant capacity and has documented therapeutic properties for a variety of pathogenic diseases. Materials and methods: Solvent extracts of T. lanceolata berry and leaf were investigated for the ability to block G. duodenalis growth. The IC 50 values of the extracts which displayed inhibitory activity were determined to quantify and compare their efficacies. Toxicity was determined using the Artemia franciscana nauplii bioassay. Active extracts were analysed by non-targeted HPLC-QTOF mass spectroscopy (with screening against 3 compound databases) for the identification and characterisation of individual components in crude plant extracts. Results: Methanolic, aqueous and ethyl acetate T. lanceolata berry and leaf extracts displayed potent G. duodenalis growth inhibitory activity. The methanolic extracts were the most potent growth inhibitors with IC 50 values of approximately 180 µg/ml and 420 µg/ml for the berry and leaf methanolic extracts respectively. The aqueous, ethyl acetate, chloroform and hexane extracts also inhibited G. duodenalis growth, albeit with lower potency. HPLC-QTOF mass spectroscopy analysis of the extracts

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Section: Discussionmentioning

confidence: 74%

Phytochemical Analysis of Tasmannia lanceolata Extracts and Inhibition of Giardia duodenalis Proliferation

Rayan¹,

Matthews²,

Donnell³

et al. 2016

Phcogj

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“…These data did not differ from those obtained for the control group, thus we can infer that the reduction in the germinability and early growth of sesame occurred specifically as a result of the presence of allelopathic phytotoxins in the aqueous leaf extracts of D. brasiliensis. Drimane sesquiterpenes, aromadendranes, monoterpenes and flavonoids are secondary metabolites reported in D. brasiliensis (Mecchi and Lago et al, 2013;Claudino et al, 2013;Limberger et al, 2007;Malheiros et al, 2005) and they may be involved with the phytotoxic activity observed for this species. However, further studies are necessary to identify the compounds responsible for the observed effects.…”

Section: Resultsmentioning

confidence: 97%

“…Compounds isolated from the leaves and stem bark of D. brasiliensis include drimane sesquiterpenes, monoterpenes and flavonoids (Mecchi and Lago et al, 2013;Limberger et al, 2007;Malheiros et al, 2005). Studies on the biological activities of these constituents have been focused specifically on pharmacological properties (Claudino et al, 2013;Malheiros et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Seasonal variation in phytotoxicity of Drimys brasiliensis Miers

Anese¹,

Grisi²,

Jatobá³

et al. 2014

Idesia

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Drimys brasiliensis Miers (Winteraceae), commonly called casca d'anta, is found in the Atlantic Forest and in Cerrado domain. It is considered an important source of natural compounds with pharmacological properties, however little is known about their phytotoxic potential on other plants. This study aims to evaluate the phytotoxic effects of D. brasiliensis leaf extracts collected in two seasons (dry and rainy) on the germination and seedling growth of Sesamum indicum L., as well as evaluating the effect of the most active extract on metaxylem cell size in the roots of the target species. The aqueous extract was prepared with 10 g of dried, ground leaves dissolved in 100 mL of distilled water, resulting in a 10% extract concentrate. Dilutions were made with distilled water to 7.5; 5.0; 2.5% and 0% (control). The leaf extracts showed phytotoxicity on germination and early growth of sesame, with more pronounced activity in leaves collected in the dry season. The inhibitory effects were observed at the cellular level in sesame roots, with a significant reduction in the size of the metaxylem cells in the presence of all concentrations of leaf extract. The extract from leaves of D. brasiliensis may constitute a promising source in the search for natural phytotoxins for use in sustainable agriculture practices.Key words: inhibition, seasonality, germinability, metaxylem, sesame. RESUMEN Drimys brasiliensis

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“…The stem bark of D. brasiliensis is of great ethnobotanical value in Brazil because it is used as a medicinal plant with antifungal, antibacterial, antiinflammatory and antiallergic properties to treat pain and malaria, and many scientific studies have demonstrated these properties (CECHINEL-FILHO et al, 1998;MALHEIROS et al, 2001;SILVEIRA et al, 2012;CLAUDINO et al, 2013). Moreover, several sesquiterpene compounds that are related to these medicinal properties have been isolated from the stem bark of this species (MALHEIROS et al, 2001); these compounds might also play a role in the phytotoxic effects observed for this species, since in this study we observed the phytotoxic effects on the germination and early growth of wheat and radish.…”

Section: Resultsmentioning

confidence: 99%

“…In this species, sesquiterpene drimanes are predominant, including polygodial, 1-β-(p-methoxycinnamoyl)-polygodial and drimanial CECHINEL-FILHO et al, 1998;MALHEIROS et al, 2001;. These compounds exhibit antinociceptive (EL-SAYAH et al, 2000), antihyperalgesic (MEN-DES et al, 1998), antifungal (MALHEIROS et al, 2005, anti-inflammatory (LAGO et al, 2010), antibacterial (SILVEIRA et al, 2012), leishmanicidal and antimalarial activities (CORRÊA et al, 2011;CLAUDINO et al, 2013). However, few studies have examined the phytotoxicity of D. brasiliensis on other plants.…”

Section: Introductionmentioning

confidence: 99%

Phytotoxic activity of differents plant parts of Drimys brasiliensis miers on germination and seedling development

Anese¹,

Grisi²,

Jatobá³

et al. 2015

Biosci. J.

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ABSTRACT:The aim of this study was to evaluate the phytotoxic activity of aqueous extracts from mature leaves, stem bark and roots of Drimys brasiliensis Miers on germination and initial seedling development of two target species, Triticum aestivum L. (wheat) and Raphanus sativus L. (radish). The aqueous extract was prepared in a proportion of 10 g of plant powder, dissolved in 100 mL of distilled water, resulting in a 10% extract concentrate. Dilutions were made with distilled water to 7.5; 5.0; 2.5% and 0% (control). Germination and seedling growth bioassays were carried out under controlled laboratory conditions. The different plant parts exerted inhibitory effects on germination and early growth of wheat and radish, however, the extract obtained from the leaves was more effective in inhibiting the germination of radish. All plant parts of D. brasiliensis may constitute a promising source in the search for compounds capable of acting as natural phytotoxins.

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Drimanes from Drimys brasiliensis with leishmanicidal and antimalarial activity

Cited by 23 publications

References 13 publications

Phytochemical Analysis of Tasmannia lanceolata Extracts and Inhibition of Giardia duodenalis Proliferation

Phytochemical Analysis of Tasmannia lanceolata Extracts and Inhibition of Giardia duodenalis Proliferation

Seasonal variation in phytotoxicity of Drimys brasiliensis Miers

Phytotoxic activity of differents plant parts of Drimys brasiliensis miers on germination and seedling development

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