Drinking-water exposure to a mixture of nitrate and low-dose atrazine metabolites and small-for-gestational age (SGA) babies: A historic cohort study

Migeot, Virginie; Albouy-Llaty, Marion; Carles, Camille; Limousi, Frédérike; Strezlec, Sylvie; Dupuis, Antoine; Rabouan, Sylvie

doi:10.1016/j.envres.2012.12.007

Cited by 64 publications

(62 citation statements)

References 52 publications

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“…Of those, 12 studies assessed congenital malformations (Munger et al, 1992; Garry et al, 1996; Meyer et al, 2006; Rull et al, 2006a; Mattix et al, 2007; Weselak et al, 2008; Ochoa-Acuña and Carbajo, 2009; Winchester et al, 2009; Waller et al, 2010; Agopian et al, 2013a, 2013b, 2013c), nine studies examined pregnancy outcomes other than malformations (Munger et al, 1997; Savitz et al, 1997; Arbuckle et al, 2001; Dąbrowski et al, 2003; Villanueva et al, 2005; Ochoa-Acuña et al, 2009; Rinsky et al, 2012; Limousi et al, 2013; Migeot et al, 2013), and one study (Chevrier et al, 2011) included both types of endpoints. Three studies included in the review were conducted in Canada (Savitz et al, 1997; Arbuckle et al, 2001; Weselak et al, 2008), four in France (Villanueva et al, 2005; Chevrier et al, 2011; Limousi et al, 2013; Migeot et al, 2013), one in Poland (Dąbrowski et al, 2003), and the remaining 14 in the United States. Not all studies were entirely independent.…”

Section: Resultsmentioning

confidence: 99%

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Atrazine and Pregnancy Outcomes: A Systematic Review of Epidemiologic Evidence

Goodman

Mandel

DeSesso

et al. 2014

Birth Defects Research Pt B

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Atrazine (ATR) is a commonly used agricultural herbicide that has been the subject of epidemiologic studies assessing its relation to reproductive health problems. This review evaluates both the consistency and the quality of epidemiologic evidence testing the hypothesis that ATR exposure, at usually encountered levels, is a risk factor for birth defects, small for gestational age birth weight, prematurity, miscarriages, and problems of fetal growth and development. We followed the current methodological guidelines for systematic reviews by using two independent researchers to identify, retrieve, and evaluate the relevant epidemiologic literature on the relation of ATR to various adverse outcomes of birth and pregnancy. Each eligible paper was summarized with respect to its methods and results with particular attention to study design and exposure assessment, which have been cited as the main areas of weakness in ATR research. As a quantitative meta-analysis was not feasible, the study results were categorized qualitatively as positive, null, or mixed. The literature on ATR and pregnancy-related health outcomes is growing rapidly, but the quality of the data is poor with most papers using aggregate rather than individual-level information. Without good quality data, the results are difficult to assess; however, it is worth noting that none of the outcome categories demonstrated consistent positive associations across studies. Considering the poor quality of the data and the lack of robust findings across studies, conclusions about a causal link between ATR and adverse pregnancy outcomes are not warranted.

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Section: Resultsmentioning

confidence: 99%

“…Two studies (Limousi et al, 2013; Migeot et al, 2013) did not report the results in terms of ORs, but did provide information sufficient to reconstruct the two-by-two tables. For those studies the ORs and the 95% CIs were calculated by one of the authors (MG) using OpenEpi statistical software (Sullivan et al, 2009a).…”

Section: Approachmentioning

confidence: 99%

Atrazine and Pregnancy Outcomes: A Systematic Review of Epidemiologic Evidence

Goodman

Mandel

DeSesso

et al. 2014

Birth Defects Research Pt B

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“…SDWIS data have been utilized in several epidemiological studies in the United States (Rinksy et al, 2012;Ochoa-Acuna et al, 2009;Ward et al, 2007;Weyer et al, 2001;Munger et al, 1997), and similar data have been used in other countries (Migeot et al, 2013;Chang et al, 2010;Villanueva et al, 2005). Since the water quality measurements are relatively infrequent in a calendar year, epidemiological studies have generally averaged data across years and CWSs (Rinksy et al, 2012;Weyer et al, 2001) or restricted the study population to metropolitan areas served by a single CWS, with or without supplemental monitoring programs (Munger et al, 1997;Ochoa-Acuna et al, 2009;Chang et al, 2010).…”

Section: Introductionmentioning

confidence: 98%

Multiple imputation for assessment of exposures to drinking water contaminants: Evaluation with the Atrazine Monitoring Program

Jones

Stayner

Demirtaş

2014

Environmental Research

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“…Based on a study in 2004 -2007, out of the 27 monitoring stations in the European Union, two thirds had average nitrate concentrations below 25 mg/L and only 15% had average nitrate concentrations above 50 mg/L in ground water. In surface water, 21%, 37%, 3%, and 3% of the stations had average nitrate concentrations below 2, 2 -10, 40 -50, and 50 mg/L, respectively (4). One study showed that two thirds of groundwater resources had average nitrate concentrations of 50 mg/L during four consecutive years (2004 -2007) in Europe (4).…”

Section: Introductionmentioning

confidence: 99%

“…In surface water, 21%, 37%, 3%, and 3% of the stations had average nitrate concentrations below 2, 2 -10, 40 -50, and 50 mg/L, respectively (4). One study showed that two thirds of groundwater resources had average nitrate concentrations of 50 mg/L during four consecutive years (2004 -2007) in Europe (4).…”

Section: Introductionmentioning

confidence: 99%

Optimizing Electrocoagulation Process for the Removal of Nitrate From Aqueous Solution

Dehghani

Hoseini

Fath-Aabaadi

et al. 2016

Jundishapur J Health Sci

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Background: High levels of nitrate anion are frequently detected in many groundwater resources in Fars province. Objectives: The present study aimed to determine the removal efficiency of nitrate from aqueous solutions by electrocoagulation process using aluminum and iron electrodes. Materials and Methods: A laboratory-scale batch reactor was conducted to determine nitrate removal efficiency using the electrocoagulation method. The removal of nitrate was determined at pH levels of 3, 7, and 11, different voltages (15, 20, and 30 V), and operation times of 30, 60, and 75 min, respectively. Data were analyzed using the SPSS software version 16 (Chicago, Illinois, USA) and Pearson's correlation coefficient was used to analyze the relationship between the parameters. Results: Results of the present study showed that the removal efficiency was increased from 27% to 86% as pH increased from 3 to 11 at the optimal condition of 30 V and 75 min operation time. Moreover, by increasing the reaction time from 30 V to 75 min the removal efficiency was increased from 63% to 86%, respectively (30 V and pH = 11). Pearson's correlation analysis showed that there was a significant relationship between removal efficiency and voltage and reaction time as well (P < 0.01). Conclusions:In conclusion, the electrocoagulation process can be used for removing nitrate from water resources because of high efficiency, simplicity, and relatively low cost.

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Drinking-water exposure to a mixture of nitrate and low-dose atrazine metabolites and small-for-gestational age (SGA) babies: A historic cohort study

Cited by 64 publications

References 52 publications

Atrazine and Pregnancy Outcomes: A Systematic Review of Epidemiologic Evidence

Atrazine and Pregnancy Outcomes: A Systematic Review of Epidemiologic Evidence

Multiple imputation for assessment of exposures to drinking water contaminants: Evaluation with the Atrazine Monitoring Program

Optimizing Electrocoagulation Process for the Removal of Nitrate From Aqueous Solution

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